IMPLANTABLE ANALYTE SENSOR
First Claim
1. A method for implanting an analyte sensor in a host, the method comprising:
- forming a precisely dimensioned pocket in a subcutaneous space of a host, wherein the pocket is dimensioned no greater than dimensions of an analyte sensor; and
inserting the analyte sensor into the precisely dimensioned pocket so as to minimize movement of the sensor within the pocket.
1 Assignment
0 Petitions
Accused Products
Abstract
An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
685 Citations
| Analyte monitoring device and methods of use | ||
|
Patent #
US 7,885,699 B2
Filed 08/06/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Biointerface membranes incorporating bioactive agents | ||
|
Patent #
US 7,875,293 B2
Filed 05/10/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Calibration techniques for a continuous analyte sensor | ||
|
Patent #
US 7,917,186 B2
Filed 11/16/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for providing continuous calibration of implantable analyte sensors | ||
|
Patent #
US 7,885,698 B2
Filed 02/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 7,884,729 B2
Filed 08/02/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 7,885,697 B2
Filed 03/10/2005
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Optimized sensor geometry for an implantable glucose sensor | ||
|
Patent #
US 7,881,763 B2
Filed 05/02/2006
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Integrated transmitter unit and sensor introducer mechanism and methods of use | ||
|
Patent #
US 7,883,464 B2
Filed 09/30/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME | ||
|
Patent #
US 20110027458A1
Filed 07/01/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| CONTINUOUS ANALYTE SENSORS AND METHODS OF MAKING SAME | ||
|
Patent #
US 20110024043A1
Filed 07/01/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 7,869,853 B1
Filed 08/06/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable volume, shape memory actuated insulin dispensing pump | ||
|
Patent #
US 7,922,458 B2
Filed 12/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| On-body medical device securement | ||
|
Patent #
US 7,951,080 B2
Filed 10/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and method | ||
|
Patent #
US 7,920,907 B2
Filed 06/07/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 7,928,850 B2
Filed 05/08/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 7,970,448 B2
Filed 04/19/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing dynamic multi-stage signal amplification in a medical device | ||
|
Patent #
US 7,948,369 B2
Filed 08/02/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable volume, shape memory actuated insulin dispensing pump | ||
|
Patent #
US 7,993,109 B2
Filed 12/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable volume, shape memory actuated insulin dispensing pump | ||
|
Patent #
US 7,993,108 B2
Filed 04/13/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Smart messages and alerts for an infusion delivery and management system | ||
|
Patent #
US 7,981,034 B2
Filed 02/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Electrochemical analyte sensor | ||
|
Patent #
US 7,996,054 B2
Filed 02/20/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 7,974,672 B2
Filed 04/19/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 7,996,158 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,052,601 B2
Filed 08/20/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for providing integrated medication infusion and analyte monitoring system | ||
|
Patent #
US 8,029,460 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable volume, shape memory actuated insulin dispensing pump | ||
|
Patent #
US 8,029,245 B2
Filed 12/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensing biointerface | ||
|
Patent #
US 8,060,174 B2
Filed 04/14/2006
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Glucose measuring device for use in personal area network | ||
|
Patent #
US 8,066,639 B2
Filed 06/04/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Glucose measuring device integrated into a holster for a personal area network device | ||
|
Patent #
US 8,029,443 B2
Filed 09/26/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,060,173 B2
Filed 08/01/2003
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor transmitter unit configuration for a data monitoring and management system | ||
|
Patent #
US 8,029,441 B2
Filed 02/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable volume, shape memory actuated insulin dispensing pump | ||
|
Patent #
US 8,047,812 B2
Filed 12/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing integrated medication infusion and analyte monitoring system | ||
|
Patent #
US 8,029,459 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable volume, shape memory actuated insulin dispensing pump | ||
|
Patent #
US 8,047,811 B2
Filed 12/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable volume, shape memory actuated insulin dispensing pump | ||
|
Patent #
US 8,029,250 B2
Filed 12/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 7,860,544 B2
Filed 03/07/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Multi-Function Analyte Test Device and Methods Therefor | ||
|
Patent #
US 20100204557A1
Filed 02/03/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensors and methods of use | ||
|
Patent #
US 7,822,455 B2
Filed 07/31/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and Apparatus for Providing Power Management in Data Communication Systems | ||
|
Patent #
US 20100312085A1
Filed 08/18/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Therasense Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 7,792,562 B2
Filed 12/22/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Continuous glucose monitoring system and methods of use | ||
|
Patent #
US 7,811,231 B2
Filed 12/26/2003
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| IMPLANTABLE ANALYTE SENSOR | ||
|
Patent #
US 20100041971A1
Filed 10/29/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing peak detection circuitry for data communication systems | ||
|
Patent #
US 7,679,407 B2
Filed 04/27/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring and management system and methods therefor | ||
|
Patent #
US 7,801,582 B2
Filed 03/31/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Calibration techniques for a continuous analyte sensor | ||
|
Patent #
US 7,715,893 B2
Filed 12/03/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for providing basal profile modification in analyte monitoring and management systems | ||
|
Patent #
US 7,766,829 B2
Filed 11/04/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 7,835,777 B2
Filed 12/22/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing rechargeable power in data monitoring and management systems | ||
|
Patent #
US 7,756,561 B2
Filed 09/30/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 7,768,408 B2
Filed 05/17/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensors and methods of use | ||
|
Patent #
US 7,826,879 B2
Filed 02/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing dynamic multi-stage signal amplification in a medical device | ||
|
Patent #
US 7,768,387 B2
Filed 04/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed Loop Control With Improved Alarm Functions | ||
|
Patent #
US 20100057042A1
Filed 08/31/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and Apparatus for Providing Power Management in Data Communication Systems | ||
|
Patent #
US 20100099174A1
Filed 12/22/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated, Therasense Incorporated
|
| Method and apparatus for providing analyte sensor insertion | ||
|
Patent #
US 7,697,967 B2
Filed 09/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte Monitoring Device and Methods of Use | ||
|
Patent #
US 20100160748A1
Filed 03/04/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 7,768,386 B2
Filed 07/31/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Close proximity communication device and methods | ||
|
Patent #
US 7,826,382 B2
Filed 05/30/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| ANALYTE SENSOR | ||
|
Patent #
US 20090036763A1
Filed 10/14/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and System for Providing Integrated Analyte Monitoring and Infusion System Therapy Management | ||
|
Patent #
US 20090054750A1
Filed 08/07/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing temperature sensor module in a data communication system | ||
|
Patent #
US 20090082693A1
Filed 12/29/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Therasense Incorporated
|
| Variable Volume, Shape Memory Actuated Insulin Dispensing Pump | ||
|
Patent #
US 20090112156A1
Filed 12/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring devices and methods therefor | ||
|
Patent #
US 20090105570A1
Filed 03/31/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| CONTINUOUS MEDICAMENT SENSOR SYSTEM FOR IN VIVO USE | ||
|
Patent #
US 20090299156A1
Filed 02/04/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte Monitoring and Therapy Management System and Methods Therefor | ||
|
Patent #
US 20080004601A1
Filed 06/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated Analyte Sensor and Infusion Device and Methods Therefor | ||
|
Patent #
US 20080004515A1
Filed 06/30/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| SILICONE COMPOSITION FOR BIOCOMPATIBLE MEMBRANE | ||
|
Patent #
US 20080045824A1
Filed 06/14/2007
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| ANALYTE MONITORING SYSTEM AND METHOD | ||
|
Patent #
US 20080071158A1
Filed 06/07/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| VARIABLE SPEED SENSOR INSERTION DEVICES AND METHODS OF USE | ||
|
Patent #
US 20080114280A1
Filed 10/23/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| METHOD AND APPARATUS FOR PROVIDING POWER MANAGEMENT IN DATA COMMUNICATION SYSTEMS | ||
|
Patent #
US 20080146900A1
Filed 02/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| TRANSCUTANEOUS ANALYTE SENSOR | ||
|
Patent #
US 20080242961A1
Filed 06/11/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Integrated transmitter unit and sensor introducer mechanism and methods of use | ||
|
Patent #
US 20070078320A1
Filed 09/30/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte Monitoring Device and Methods of Use | ||
|
Patent #
US 20070149874A1
Filed 03/07/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte Monitoring Device and Methods of Use | ||
|
Patent #
US 20070203408A1
Filed 04/30/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Smart messages and alerts for an infusion delivery and management system | ||
|
Patent #
US 20070213657A1
Filed 02/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Optimized sensor geometry for an implantable glucose sensor | ||
|
Patent #
US 20060211921A1
Filed 05/02/2006
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing power management in data communication systems | ||
|
Patent #
US 20050009126A1
Filed 06/04/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Therasense Incorporated
|
| Biointerface membranes incorporating bioactive agents | ||
|
Patent #
US 20050031689A1
Filed 05/10/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Calibration techniques for a continuous analyte sensor | ||
|
Patent #
US 20050143635A1
Filed 12/03/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing rolling data in communication systems | ||
|
Patent #
US 8,123,686 B2
Filed 03/01/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,103,471 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Signal converting cradle for medical condition monitoring and management system | ||
|
Patent #
US 8,085,151 B2
Filed 06/26/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method of calibrating of an analyte-measurement device, and associated methods, devices and systems | ||
|
Patent #
US 8,116,840 B2
Filed 10/30/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 8,089,363 B2
Filed 02/07/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| RF tag on test strips, test strip vials and boxes | ||
|
Patent #
US 8,115,635 B2
Filed 11/24/2009
|
Current Assignee
Therasense Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring and management system and methods therefor | ||
|
Patent #
US 8,086,292 B2
Filed 10/27/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing rechargeable power in data monitoring and management systems | ||
|
Patent #
US 8,112,138 B2
Filed 09/26/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing leak detection in data monitoring and management systems | ||
|
Patent #
US 8,112,240 B2
Filed 04/29/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Porous membranes for use with implantable devices | ||
|
Patent #
US 8,118,877 B2
Filed 01/17/2007
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Device and method for automatic data acquisition and/or detection | ||
|
Patent #
US 8,121,857 B2
Filed 02/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors | ||
|
Patent #
US 8,135,548 B2
Filed 10/26/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated, University of Virginia Patent Foundation
|
| Method and apparatus for providing dynamic multi-stage amplification in a medical device | ||
|
Patent #
US 8,149,103 B2
Filed 05/23/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 8,149,117 B2
Filed 08/29/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in medical communication system | ||
|
Patent #
US 8,140,142 B2
Filed 04/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for determining analyte levels | ||
|
Patent #
US 8,140,312 B2
Filed 01/31/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 8,155,723 B2
Filed 01/28/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Calibration techniques for a continuous analyte sensor | ||
|
Patent #
US 8,160,671 B2
Filed 09/01/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring and management device and method to analyze the frequency of user interaction with the device | ||
|
Patent #
US 8,160,900 B2
Filed 06/26/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,162,829 B2
Filed 03/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for replacing signal artifacts in a glucose sensor data stream | ||
|
Patent #
US 8,167,801 B2
Filed 03/25/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,175,673 B2
Filed 11/09/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,177,716 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for detecting false hypoglycemic conditions | ||
|
Patent #
US 8,185,181 B2
Filed 10/29/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Electrode systems for electrochemical sensors | ||
|
Patent #
US RE43,399 E1
Filed 06/13/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Continuous glucose monitoring system and methods of use | ||
|
Patent #
US 8,187,183 B2
Filed 10/11/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing integrated analyte monitoring and infusion system therapy management | ||
|
Patent #
US 8,206,296 B2
Filed 08/07/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing analyte monitoring | ||
|
Patent #
US 8,211,016 B2
Filed 09/26/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method of calibrating an analyte-measurement device, and associated methods, devices and systems | ||
|
Patent #
US 8,219,175 B2
Filed 06/29/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method of calibrating an analyte-measurement device, and associated methods, devices and systems | ||
|
Patent #
US 8,219,174 B2
Filed 06/29/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration | ||
|
Patent #
US 8,216,138 B1
Filed 10/23/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing analyte monitoring | ||
|
Patent #
US 8,216,137 B2
Filed 07/20/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Optimizing analyte sensor calibration | ||
|
Patent #
US 8,219,173 B2
Filed 09/30/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,224,413 B2
Filed 10/10/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and device for providing offset model based calibration for analyte sensor | ||
|
Patent #
US 8,224,415 B2
Filed 01/29/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| RF tag on test strips, test strip vials and boxes | ||
|
Patent #
US 8,223,021 B2
Filed 11/24/2009
|
Current Assignee
Therasense Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,226,558 B2
Filed 09/27/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,226,557 B2
Filed 12/28/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,226,555 B2
Filed 03/18/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring devices and methods therefor | ||
|
Patent #
US 8,226,891 B2
Filed 03/31/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for blood glucose monitoring and alert delivery | ||
|
Patent #
US 8,229,535 B2
Filed 02/20/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,231,532 B2
Filed 04/30/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,239,166 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,235,896 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Calibration techniques for a continuous analyte sensor | ||
|
Patent #
US 8,249,684 B2
Filed 09/01/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for sterilizing an analyte sensor | ||
|
Patent #
US 8,252,229 B2
Filed 04/10/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,255,031 B2
Filed 03/17/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,260,392 B2
Filed 06/09/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,260,558 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,265,726 B2
Filed 11/09/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Apparatus for providing power management in data communication systems | ||
|
Patent #
US 8,273,295 B2
Filed 11/24/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,273,022 B2
Filed 02/13/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,275,439 B2
Filed 11/09/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 8,275,437 B2
Filed 03/23/2007
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,287,454 B2
Filed 09/27/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor | ||
|
Patent #
US 8,287,453 B2
Filed 11/07/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,306,598 B2
Filed 11/09/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing an integrated analyte sensor insertion device and data processing unit | ||
|
Patent #
US 8,333,714 B2
Filed 09/10/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Fluid delivery device with autocalibration | ||
|
Patent #
US 8,343,093 B2
Filed 05/28/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing integrated medication infusion and analyte monitoring system | ||
|
Patent #
US 8,343,092 B2
Filed 11/24/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing a fault tolerant display unit in an electronic device | ||
|
Patent #
US 8,344,966 B2
Filed 01/31/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,346,336 B2
Filed 03/18/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,346,337 B2
Filed 06/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor calibration management | ||
|
Patent #
US 8,346,335 B2
Filed 01/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,353,829 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,357,091 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| RF tag on test strips, test strip vials and boxes | ||
|
Patent #
US 8,358,210 B2
Filed 11/24/2009
|
Current Assignee
Therasense Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 8,362,904 B2
Filed 04/18/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,366,614 B2
Filed 03/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 8,368,556 B2
Filed 04/29/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,372,005 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor with lag compensation | ||
|
Patent #
US 8,374,668 B1
Filed 10/23/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing calibration of an analyte sensor in an analyte monitoring system | ||
|
Patent #
US 8,376,945 B2
Filed 11/23/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control system with safety parameters and methods | ||
|
Patent #
US 8,377,031 B2
Filed 08/31/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,380,273 B2
Filed 04/11/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| RF tag on test strips, test strip vials and boxes | ||
|
Patent #
US 8,390,455 B2
Filed 11/24/2009
|
Current Assignee
Therasense Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,391,945 B2
Filed 03/17/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,394,021 B2
Filed 10/01/2007
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,409,131 B2
Filed 03/07/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Assessing measures of glycemic variability | ||
|
Patent #
US 8,409,093 B2
Filed 10/23/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for automatic data acquisition and/or detection | ||
|
Patent #
US 8,417,545 B2
Filed 02/17/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing dynamic multi-stage amplification in a medical device | ||
|
Patent #
US 8,427,298 B2
Filed 04/02/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Calibration techniques for a continuous analyte sensor | ||
|
Patent #
US 8,428,678 B2
Filed 05/16/2012
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for transferring analyte test data | ||
|
Patent #
US 8,437,966 B2
Filed 11/20/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,442,610 B2
Filed 08/21/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,444,560 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 8,456,301 B2
Filed 05/08/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Glucose measuring module and insulin pump combination | ||
|
Patent #
US 8,460,243 B2
Filed 06/10/2003
|
Current Assignee
Smiths Medical ASD Inc.
|
Original Assignee
Abbott Diabetes Care Incorporated, Deltek Inc.
|
| Analyte monitoring system and methods | ||
|
Patent #
US 8,461,985 B2
Filed 05/08/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Electrochemical analyte sensor | ||
|
Patent #
US 8,463,351 B2
Filed 08/06/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,465,425 B2
Filed 06/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop blood glucose control algorithm analysis | ||
|
Patent #
US 8,467,972 B2
Filed 04/28/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 8,471,714 B2
Filed 12/30/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,473,021 B2
Filed 07/31/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor with time lag compensation | ||
|
Patent #
US 8,473,022 B2
Filed 01/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte monitoring system calibration accuracy | ||
|
Patent #
US 8,478,557 B2
Filed 07/30/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,480,580 B2
Filed 04/19/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing real time analyte sensor calibration with retrospective backfill | ||
|
Patent #
US 8,483,967 B2
Filed 04/28/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for determining analyte levels | ||
|
Patent #
US 8,484,005 B2
Filed 03/19/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for transferring analyte test data | ||
|
Patent #
US 8,483,974 B2
Filed 11/20/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system having an alert | ||
|
Patent #
US 8,497,777 B2
Filed 04/15/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Signal converting cradle for medical condition monitoring and management system | ||
|
Patent #
US 8,502,682 B2
Filed 12/23/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing continuous calibration of implantable analyte sensors | ||
|
Patent #
US 8,506,482 B2
Filed 02/07/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Close proximity communication device and methods | ||
|
Patent #
US 8,509,107 B2
Filed 11/01/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensor head for use with implantable devices | ||
|
Patent #
US 8,509,871 B2
Filed 10/28/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Integrated introducer and transmitter assembly and methods of use | ||
|
Patent #
US 8,512,243 B2
Filed 09/30/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing peak detection circuitry for data communication systems | ||
|
Patent #
US 8,512,246 B2
Filed 03/15/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Glucose measuring device for use in personal area network | ||
|
Patent #
US 8,512,239 B2
Filed 04/20/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated analyte sensor and infusion device and methods therefor | ||
|
Patent #
US 8,512,244 B2
Filed 09/26/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for dynamically updating calibration parameters for an analyte sensor | ||
|
Patent #
US 8,515,517 B2
Filed 09/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 8,514,086 B2
Filed 08/30/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 8,527,025 B1
Filed 11/22/1999
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 8,527,026 B2
Filed 03/02/2012
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and device for providing offset model based calibration for analyte sensor | ||
|
Patent #
US 8,532,935 B2
Filed 07/16/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Glucose measurement device and methods using RFID | ||
|
Patent #
US 8,542,122 B2
Filed 01/17/2013
|
Current Assignee
Therasense Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring and management system and methods therefor | ||
|
Patent #
US 8,543,183 B2
Filed 12/23/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device insertion | ||
|
Patent #
US 8,545,403 B2
Filed 12/28/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,560,038 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for transferring analyte test data | ||
|
Patent #
US 8,560,250 B2
Filed 08/18/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Laboratories Incorporated
|
| Computerized determination of insulin pump therapy parameters using real time and retrospective data processing | ||
|
Patent #
US 8,560,082 B2
Filed 01/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for mounting a data transmission device in a communication system | ||
|
Patent #
US 8,571,624 B2
Filed 12/29/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,571,808 B2
Filed 01/23/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Infusion devices and methods | ||
|
Patent #
US 8,579,853 B2
Filed 10/31/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor calibration management | ||
|
Patent #
US 8,583,205 B2
Filed 04/16/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing basal profile modification in analyte monitoring and management systems | ||
|
Patent #
US 8,585,591 B2
Filed 07/10/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Subcutaneous glucose electrode | ||
|
Patent #
US 8,588,881 B2
Filed 03/02/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing glycemic control | ||
|
Patent #
US 8,591,410 B2
Filed 06/01/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for customizing delivery of sensor data | ||
|
Patent #
US 8,591,455 B2
Filed 02/20/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 8,593,287 B2
Filed 07/20/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for powering an electronic device | ||
|
Patent #
US 8,593,109 B2
Filed 11/03/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Health management devices and methods | ||
|
Patent #
US 8,597,188 B2
Filed 06/20/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,597,189 B2
Filed 03/03/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring devices and methods therefor | ||
|
Patent #
US 8,597,575 B2
Filed 07/23/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,600,681 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor introducer and methods of use | ||
|
Patent #
US 8,602,991 B2
Filed 06/07/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,612,159 B2
Filed 02/16/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,612,163 B2
Filed 08/30/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Insertion devices and methods | ||
|
Patent #
US 8,613,703 B2
Filed 05/29/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte meter with a moveable head and methods of using the same | ||
|
Patent #
US 8,613,892 B2
Filed 06/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Health monitor | ||
|
Patent #
US 8,617,069 B2
Filed 06/20/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,617,071 B2
Filed 06/21/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Continuous glucose monitoring system and methods of use | ||
|
Patent #
US 8,622,903 B2
Filed 05/25/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,622,905 B2
Filed 12/11/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,622,906 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Variable rate closed loop control and methods | ||
|
Patent #
US 8,622,988 B2
Filed 08/31/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for evaluating analyte sensor response characteristics | ||
|
Patent #
US 8,635,046 B2
Filed 06/22/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data communication in data monitoring and management systems | ||
|
Patent #
US 8,638,220 B2
Filed 05/23/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,641,619 B2
Filed 12/21/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and structure for securing a monitoring device element | ||
|
Patent #
US 8,641,618 B2
Filed 06/26/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Glucose measuring device for use in personal area network | ||
|
Patent #
US 8,647,269 B2
Filed 04/20/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,649,841 B2
Filed 04/03/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,652,043 B2
Filed 07/20/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 8,653,977 B2
Filed 06/21/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,660,627 B2
Filed 03/17/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and device for determining elapsed sensor life | ||
|
Patent #
US 8,665,091 B2
Filed 06/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,666,469 B2
Filed 11/16/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,668,645 B2
Filed 01/03/2003
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,670,815 B2
Filed 04/30/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,672,844 B2
Filed 02/27/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,676,287 B2
Filed 12/11/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and device for early signal attenuation detection using blood glucose measurements | ||
|
Patent #
US 8,676,513 B2
Filed 06/21/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 8,676,288 B2
Filed 06/22/2011
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Device and method for automatic data acquisition and/or detection | ||
|
Patent #
US 8,676,601 B2
Filed 04/08/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 8,682,615 B2
Filed 08/04/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for transferring analyte test data | ||
|
Patent #
US 8,682,598 B2
Filed 08/27/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Laboratories Incorporated
|
| Method of calibrating an analyte-measurement device, and associated methods, devices and systems | ||
|
Patent #
US 8,684,930 B2
Filed 06/29/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,688,188 B2
Filed 06/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing dynamic multi-stage signal amplification in a medical device | ||
|
Patent #
US 8,698,615 B2
Filed 04/22/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,700,117 B2
Filed 12/08/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Electrochemical analyte sensor | ||
|
Patent #
US 8,706,180 B2
Filed 06/10/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Mitigating single point failure of devices in an analyte monitoring system and methods thereof | ||
|
Patent #
US 8,710,993 B2
Filed 11/21/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor calibration management | ||
|
Patent #
US 8,718,739 B2
Filed 12/28/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte monitoring system calibration accuracy | ||
|
Patent #
US 8,718,965 B2
Filed 06/24/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors | ||
|
Patent #
US 8,718,958 B2
Filed 03/12/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated, University of Virginia Patent Foundation
|
| Method and system for providing integrated analyte monitoring and infusion system therapy management | ||
|
Patent #
US 8,727,982 B2
Filed 06/25/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system having an alert | ||
|
Patent #
US 8,730,058 B2
Filed 07/29/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,734,348 B2
Filed 03/17/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| On-body medical device securement | ||
|
Patent #
US 8,734,344 B2
Filed 05/29/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control with improved alarm functions | ||
|
Patent #
US 8,734,422 B2
Filed 08/31/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,734,346 B2
Filed 04/30/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Close proximity communication device and methods | ||
|
Patent #
US 8,737,259 B2
Filed 08/05/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,738,109 B2
Filed 03/03/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Subcutaneous glucose electrode | ||
|
Patent #
US 8,741,590 B2
Filed 04/03/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Optimizing analyte sensor calibration | ||
|
Patent #
US 8,744,547 B2
Filed 07/09/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,744,545 B2
Filed 03/03/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 8,764,657 B2
Filed 03/30/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 8,771,183 B2
Filed 02/16/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,774,887 B2
Filed 03/24/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data | ||
|
Patent #
US 8,788,006 B2
Filed 12/11/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 8,792,955 B2
Filed 06/09/2011
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 8,792,953 B2
Filed 03/19/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Robust closed loop control and methods | ||
|
Patent #
US 8,795,252 B2
Filed 10/16/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Real time management of data relating to physiological control of glucose levels | ||
|
Patent #
US 8,798,934 B2
Filed 07/23/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for sterilizing an analyte sensor | ||
|
Patent #
US 8,802,006 B2
Filed 08/27/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 8,816,862 B2
Filed 08/19/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte sensor calibration | ||
|
Patent #
US 8,834,366 B2
Filed 07/31/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Membrane for use with implantable devices | ||
|
Patent #
US 8,840,552 B2
Filed 12/08/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,840,553 B2
Filed 02/26/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte sensor insertion | ||
|
Patent #
US 8,852,101 B2
Filed 09/30/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing an integrated analyte sensor insertion device and data processing unit | ||
|
Patent #
US 8,862,198 B2
Filed 12/17/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control system interface and methods | ||
|
Patent #
US 8,876,755 B2
Filed 07/14/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,880,137 B2
Filed 04/18/2003
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device for channeling fluid and methods of use | ||
|
Patent #
US 8,880,138 B2
Filed 09/30/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Apparatus for providing power management in data communication systems | ||
|
Patent #
US 8,906,307 B2
Filed 08/18/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,915,850 B2
Filed 03/28/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,920,319 B2
Filed 12/28/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 8,923,947 B2
Filed 07/23/2013
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing glycemic control | ||
|
Patent #
US 8,924,159 B2
Filed 06/01/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Multi-function analyte test device and methods therefor | ||
|
Patent #
US 8,930,203 B2
Filed 02/03/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for powering an electronic device | ||
|
Patent #
US 8,933,664 B2
Filed 11/25/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in integrated analyte monitoring and infusion system | ||
|
Patent #
US 8,932,216 B2
Filed 08/07/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing dynamic multi-stage signal amplification in a medical device | ||
|
Patent #
US 8,937,540 B2
Filed 02/24/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 8,974,386 B2
Filed 11/01/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 8,986,209 B2
Filed 07/13/2012
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor sensitivity attenuation mitigation | ||
|
Patent #
US 8,986,208 B2
Filed 09/30/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods for managing power and noise | ||
|
Patent #
US 8,993,331 B2
Filed 08/31/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 9,000,929 B2
Filed 11/22/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in medical communication system | ||
|
Patent #
US 9,008,743 B2
Filed 04/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,011,332 B2
Filed 10/30/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,011,331 B2
Filed 12/29/2004
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,014,773 B2
Filed 03/07/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for processing, transmitting and displaying sensor data | ||
|
Patent #
US 9,020,572 B2
Filed 09/10/2010
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensors and methods of use | ||
|
Patent #
US 9,031,630 B2
Filed 11/01/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 9,035,767 B2
Filed 05/30/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring devices and methods therefor | ||
|
Patent #
US 9,039,975 B2
Filed 12/02/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,042,953 B2
Filed 03/02/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for detecting false hypoglycemic conditions | ||
|
Patent #
US 9,050,041 B2
Filed 05/21/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Infusion devices and methods | ||
|
Patent #
US 9,064,107 B2
Filed 09/30/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 9,060,719 B2
Filed 12/13/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,066,695 B2
Filed 04/12/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,066,697 B2
Filed 10/27/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and device for early signal attenuation detection using blood glucose measurements | ||
|
Patent #
US 9,066,709 B2
Filed 03/17/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Electronic devices having integrated reset systems and methods thereof | ||
|
Patent #
US 9,069,536 B2
Filed 10/30/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,066,694 B2
Filed 04/03/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,072,477 B2
Filed 06/21/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,078,607 B2
Filed 06/17/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 9,088,452 B2
Filed 01/31/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing rolling data in communication systems | ||
|
Patent #
US 9,095,290 B2
Filed 02/27/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing power management in data communication systems | ||
|
Patent #
US 9,109,926 B2
Filed 12/08/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing analyte monitoring | ||
|
Patent #
US 9,113,828 B2
Filed 07/09/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated analyte sensor and infusion device and methods therefor | ||
|
Patent #
US 9,119,582 B2
Filed 06/30/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 9,125,548 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for processing, transmitting and displaying sensor data | ||
|
Patent #
US 9,143,569 B2
Filed 02/20/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 9,177,456 B2
Filed 06/10/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system having an alert | ||
|
Patent #
US 9,178,752 B2
Filed 04/25/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Close proximity communication device and methods | ||
|
Patent #
US 9,184,875 B2
Filed 04/25/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 9,186,098 B2
Filed 03/24/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 9,186,113 B2
Filed 08/11/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in medical communication system | ||
|
Patent #
US 9,204,827 B2
Filed 04/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 9,215,992 B2
Filed 03/24/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 9,226,714 B2
Filed 01/08/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Error detection in critical repeating data in a wireless sensor system | ||
|
Patent #
US 9,226,701 B2
Filed 04/28/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Flexible patch for fluid delivery and monitoring body analytes | ||
|
Patent #
US 9,259,175 B2
Filed 10/23/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 9,265,453 B2
Filed 03/24/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Mitigating single point failure of devices in an analyte monitoring system and methods thereof | ||
|
Patent #
US 9,289,179 B2
Filed 04/11/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing real time analyte sensor calibration with retrospective backfill | ||
|
Patent #
US 9,310,230 B2
Filed 06/24/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof | ||
|
Patent #
US 9,317,656 B2
Filed 11/21/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 9,314,198 B2
Filed 04/03/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte signal processing device and methods | ||
|
Patent #
US 9,314,195 B2
Filed 08/31/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing notification function in analyte monitoring systems | ||
|
Patent #
US 9,320,461 B2
Filed 09/29/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor calibration management | ||
|
Patent #
US 9,320,462 B2
Filed 05/05/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing basal profile modification in analyte monitoring and management systems | ||
|
Patent #
US 9,323,898 B2
Filed 11/15/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor with time lag compensation | ||
|
Patent #
US 9,320,468 B2
Filed 06/21/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| On-body medical device securement | ||
|
Patent #
US 9,326,727 B2
Filed 05/15/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems, devices and methods for managing glucose levels | ||
|
Patent #
US 9,326,709 B2
Filed 03/09/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,326,716 B2
Filed 12/05/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensor head for use with implantable devices | ||
|
Patent #
US 9,328,371 B2
Filed 07/16/2013
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,326,714 B2
Filed 06/29/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Alarm characterization for analyte monitoring devices and systems | ||
|
Patent #
US 9,326,707 B2
Filed 11/10/2009
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 9,332,944 B2
Filed 01/31/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor with lag compensation | ||
|
Patent #
US 9,332,934 B2
Filed 02/08/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte sensor insertion | ||
|
Patent #
US 9,332,933 B2
Filed 09/29/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 9,339,223 B2
Filed 12/30/2013
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring system and methods of use | ||
|
Patent #
US 9,339,217 B2
Filed 11/21/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Interconnect for on-body analyte monitoring device | ||
|
Patent #
US 9,351,669 B2
Filed 09/30/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for dynamically updating calibration parameters for an analyte sensor | ||
|
Patent #
US 9,357,959 B2
Filed 08/19/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor transmitter unit configuration for a data monitoring and management system | ||
|
Patent #
US 9,364,149 B2
Filed 10/03/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for powering an electronic device | ||
|
Patent #
US 9,380,971 B2
Filed 12/05/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control and signal attenuation detection | ||
|
Patent #
US 9,392,969 B2
Filed 08/31/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte sensor calibration | ||
|
Patent #
US 9,398,872 B2
Filed 08/28/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte sensor and data processing device | ||
|
Patent #
US 9,398,882 B2
Filed 09/10/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing dynamic multi-stage signal amplification in a medical device | ||
|
Patent #
US 9,402,584 B2
Filed 01/14/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor and apparatus for insertion of the sensor | ||
|
Patent #
US 9,402,544 B2
Filed 02/01/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor devices, connections, and methods | ||
|
Patent #
US 9,402,570 B2
Filed 12/11/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing calibration of an analyte sensor in an analyte monitoring system | ||
|
Patent #
US 9,408,566 B2
Filed 02/13/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 9,414,777 B2
Filed 03/10/2005
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Assessing measures of glycemic variability | ||
|
Patent #
US 9,439,586 B2
Filed 03/29/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 9,439,589 B2
Filed 11/25/2014
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 9,451,908 B2
Filed 12/19/2012
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Electronic devices having integrated reset systems and methods thereof | ||
|
Patent #
US 9,465,420 B2
Filed 06/26/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Multi-rate analyte sensor data collection with sample rate configurable signal processing | ||
|
Patent #
US 9,474,475 B1
Filed 03/13/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated introducer and transmitter assembly and methods of use | ||
|
Patent #
US 9,480,421 B2
Filed 08/19/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 9,483,608 B2
Filed 05/20/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,498,159 B2
Filed 10/30/2007
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor retention mechanism and methods of use | ||
|
Patent #
US 9,521,968 B2
Filed 09/30/2005
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Membrane for use with implantable devices | ||
|
Patent #
US 9,532,741 B2
Filed 07/25/2014
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same | ||
|
Patent #
US 9,532,737 B2
Filed 02/28/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing glycemic control | ||
|
Patent #
US 9,541,556 B2
Filed 11/25/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 9,549,694 B2
Filed 11/11/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for determining analyte levels | ||
|
Patent #
US 9,558,325 B2
Filed 06/24/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Devices, systems and methods for on-skin or on-body mounting of medical devices | ||
|
Patent #
US 9,572,534 B2
Filed 06/28/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Robust closed loop control and methods | ||
|
Patent #
US 9,572,934 B2
Filed 08/01/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and device for determining elapsed sensor life | ||
|
Patent #
US 9,574,914 B2
Filed 03/03/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 9,610,034 B2
Filed 11/09/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control with improved alarm functions | ||
|
Patent #
US 9,610,046 B2
Filed 04/29/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in medical communication system | ||
|
Patent #
US 9,615,780 B2
Filed 04/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Model based variable risk false glucose threshold alarm prevention mechanism | ||
|
Patent #
US 9,622,691 B2
Filed 10/30/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring devices and methods therefor | ||
|
Patent #
US 9,625,413 B2
Filed 05/19/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for dynamically updating calibration parameters for an analyte sensor | ||
|
Patent #
US 9,629,578 B2
Filed 03/26/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor and apparatus for insertion of the sensor | ||
|
Patent #
US 9,636,068 B2
Filed 06/24/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Pump system modular components for delivering medication and analyte sensing at seperate insertion sites | ||
|
Patent #
US 9,636,450 B2
Filed 02/15/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Udo Hoss, Gary A. Stafford
|
| Analyte monitoring system and methods | ||
|
Patent #
US 9,649,057 B2
Filed 05/11/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Optimizing analyte sensor calibration | ||
|
Patent #
US 9,662,056 B2
Filed 05/22/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing basal profile modification in analyte monitoring and management systems | ||
|
Patent #
US 9,669,162 B2
Filed 03/16/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensitivity calibration of in vivo sensors used to measure analyte concentration | ||
|
Patent #
US 9,675,290 B2
Filed 10/29/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 9,687,183 B2
Filed 03/30/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 9,693,688 B2
Filed 07/16/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor devices, connections, and methods | ||
|
Patent #
US 9,693,713 B2
Filed 06/27/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in integrated analyte monitoring and infusion system | ||
|
Patent #
US 9,697,332 B2
Filed 12/08/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for processing sensor data | ||
|
Patent #
US 9,717,449 B2
Filed 01/15/2013
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Compatibility mechanisms for devices in a continuous analyte monitoring system and methods thereof | ||
|
Patent #
US 9,721,063 B2
Filed 03/09/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Glucose measuring device for use in personal area network | ||
|
Patent #
US 9,730,584 B2
Filed 02/10/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor calibration management | ||
|
Patent #
US 9,730,623 B2
Filed 02/05/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Alarm characterization for analyte monitoring devices and systems | ||
|
Patent #
US 9,730,650 B2
Filed 01/15/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 9,737,249 B2
Filed 06/17/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing dynamic multi-stage signal amplification in a medical device | ||
|
Patent #
US 9,743,866 B2
Filed 07/13/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for powering an electronic device | ||
|
Patent #
US 9,743,863 B2
Filed 06/01/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Assessing measures of glycemic variability | ||
|
Patent #
US 9,743,865 B2
Filed 06/25/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for transcutaneously implanting medical devices | ||
|
Patent #
US 9,743,862 B2
Filed 03/29/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Mitigating single point failure of devices in an analyte monitoring system and methods thereof | ||
|
Patent #
US 9,743,872 B2
Filed 02/04/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 9,750,440 B2
Filed 04/12/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Interconnect for on-body analyte monitoring device | ||
|
Patent #
US 9,750,444 B2
Filed 04/27/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing notification function in analyte monitoring systems | ||
|
Patent #
US 9,750,439 B2
Filed 04/08/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor with time lag compensation | ||
|
Patent #
US 9,770,211 B2
Filed 04/08/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated introducer and transmitter assembly and methods of use | ||
|
Patent #
US 9,775,563 B2
Filed 09/21/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Smart messages and alerts for an infusion delivery and management system | ||
|
Patent #
US 9,782,076 B2
Filed 07/18/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensing biointerface | ||
|
Patent #
US 9,788,766 B2
Filed 05/19/2014
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Variable speed sensor insertion devices and methods of use | ||
|
Patent #
US 9,788,771 B2
Filed 10/23/2006
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Continuous analyte measurement systems and systems and methods for implanting them | ||
|
Patent #
US 9,795,326 B2
Filed 07/22/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing glycemic control | ||
|
Patent #
US 9,795,328 B2
Filed 01/06/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte sensor insertion | ||
|
Patent #
US 9,795,331 B2
Filed 04/28/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 9,797,880 B2
Filed 10/11/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing rolling data in communication systems | ||
|
Patent #
US 9,801,545 B2
Filed 07/30/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in medical communication system | ||
|
Patent #
US 9,801,571 B2
Filed 09/16/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensitivity calibration of in vivo sensors used to measure analyte concentration | ||
|
Patent #
US 9,801,577 B2
Filed 06/07/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 9,804,150 B2
Filed 03/24/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor with lag compensation | ||
|
Patent #
US 9,804,148 B2
Filed 04/29/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensor head for use with implantable devices | ||
|
Patent #
US 9,804,114 B2
Filed 03/02/2016
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for providing an integrated analyte sensor insertion device and data processing unit | ||
|
Patent #
US 9,808,186 B2
Filed 09/26/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 9,814,416 B2
Filed 12/13/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing analyte monitoring | ||
|
Patent #
US 9,814,428 B2
Filed 08/22/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Close proximity communication device and methods | ||
|
Patent #
US 9,831,985 B2
Filed 09/29/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 9,833,143 B2
Filed 06/05/2014
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for providing calibration of an analyte sensor in an analyte monitoring system | ||
|
Patent #
US 9,833,181 B2
Filed 07/13/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for dynamically updating calibration parameters for an analyte sensor | ||
|
Patent #
US 9,839,383 B2
Filed 04/21/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensors and methods of use | ||
|
Patent #
US 9,844,329 B2
Filed 05/06/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors | ||
|
Patent #
US 9,882,660 B2
Filed 04/30/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated, University of Virginia Patent Foundation
|
| Analyte sensor | ||
|
Patent #
US 9,901,293 B2
Filed 02/24/2015
|
Current Assignee
Senseonics Incorporated
|
Original Assignee
Senseonics Incorporated
|
| Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data | ||
|
Patent #
US 9,907,492 B2
Filed 09/18/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring and management device and method to analyze the frequency of user interaction with the device | ||
|
Patent #
US 9,913,600 B2
Filed 02/23/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Model based variable risk false glucose threshold alarm prevention mechanism | ||
|
Patent #
US 9,913,619 B2
Filed 04/13/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing glycemic control | ||
|
Patent #
US 9,931,075 B2
Filed 11/12/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Device and method for determining analyte levels | ||
|
Patent #
US 9,931,067 B2
Filed 09/13/2016
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor devices, connections, and methods | ||
|
Patent #
US 9,931,066 B2
Filed 05/31/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte monitoring and therapy management system accuracy | ||
|
Patent #
US 9,936,910 B2
Filed 04/25/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control with reference measurement and methods thereof | ||
|
Patent #
US 9,943,644 B2
Filed 08/31/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 9,949,639 B2
Filed 06/27/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and device for determining elapsed sensor life | ||
|
Patent #
US 9,949,678 B2
Filed 02/16/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Continuous glucose monitoring system and methods of use | ||
|
Patent #
US 9,962,091 B2
Filed 01/06/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte signal processing device and methods | ||
|
Patent #
US 9,968,302 B2
Filed 04/04/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems | ||
|
Patent #
US 9,968,306 B2
Filed 10/21/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensor inserter assembly | ||
|
Patent #
US 9,980,670 B2
Filed 04/03/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods | ||
|
Patent #
US 9,980,669 B2
Filed 11/07/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor | ||
|
Patent #
US 9,986,942 B2
Filed 08/10/2006
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor and apparatus for insertion of the sensor | ||
|
Patent #
US 9,993,188 B2
Filed 03/31/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,002,233 B2
Filed 05/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Infusion devices and methods | ||
|
Patent #
US 10,007,759 B2
Filed 06/03/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system having an alert | ||
|
Patent #
US 10,009,244 B2
Filed 10/30/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 10,010,280 B2
Filed 03/30/2012
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,022,078 B2
Filed 05/23/2006
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Device and method for automatic data acquisition and/or detection | ||
|
Patent #
US 10,022,499 B2
Filed 08/18/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Introducer assembly and methods of use | ||
|
Patent #
US 10,028,680 B2
Filed 03/19/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,031,002 B2
Filed 12/02/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Membrane for use with implantable devices | ||
|
Patent #
US 10,039,480 B2
Filed 02/11/2015
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 10,039,881 B2
Filed 07/07/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor sensitivity attenuation mitigation | ||
|
Patent #
US 10,045,739 B2
Filed 03/23/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,045,720 B2
Filed 10/15/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensor insertion devices and methods of use | ||
|
Patent #
US 10,070,810 B2
Filed 10/10/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensor fault detection using analyte sensor data pattern comparison | ||
|
Patent #
US 10,076,285 B2
Filed 03/13/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems, devices and methods for managing glucose levels | ||
|
Patent #
US 10,078,380 B2
Filed 04/07/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods of use | ||
|
Patent #
US 10,082,493 B2
Filed 04/29/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and device for providing offset model based calibration for analyte sensor | ||
|
Patent #
US 10,089,446 B2
Filed 09/03/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Calibration of analyte measurement system | ||
|
Patent #
US 10,092,229 B2
Filed 06/29/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in medical communication system | ||
|
Patent #
US 10,111,608 B2
Filed 04/14/2008
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing continuous calibration of implantable analyte sensors | ||
|
Patent #
US 10,117,614 B2
Filed 09/11/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for detecting false hypoglycemic conditions | ||
|
Patent #
US 10,117,606 B2
Filed 06/03/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,119,956 B2
Filed 10/27/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 10,123,752 B2
Filed 11/10/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Dropout detection in continuous analyte monitoring data during data excursions | ||
|
Patent #
US 10,132,793 B2
Filed 08/20/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical devices and methods | ||
|
Patent #
US 10,136,816 B2
Filed 08/31/2010
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same | ||
|
Patent #
US 10,136,845 B2
Filed 03/14/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Mitigating single point failure of devices in an analyte monitoring system and methods thereof | ||
|
Patent #
US 10,136,847 B2
Filed 08/24/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,143,409 B2
Filed 10/27/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor transmitter unit configuration for a data monitoring and management system | ||
|
Patent #
US 10,159,433 B2
Filed 04/18/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 10,172,518 B2
Filed 04/13/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control system with safety parameters and methods | ||
|
Patent #
US 10,173,007 B2
Filed 02/13/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 10,178,954 B2
Filed 05/09/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for processing sensor data | ||
|
Patent #
US 10,182,751 B2
Filed 06/26/2017
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Sensitivity calibration of in vivo sensors used to measure analyte concentration | ||
|
Patent #
US 10,188,334 B2
Filed 10/20/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control and signal attenuation detection | ||
|
Patent #
US 10,188,794 B2
Filed 06/16/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated transmitter unit and sensor introducer mechanism and methods of use | ||
|
Patent #
US 10,194,863 B2
Filed 02/07/2011
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing dynamic multi-stage signal amplification in a medical device | ||
|
Patent #
US 10,194,846 B2
Filed 08/25/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing analyte monitoring | ||
|
Patent #
US 10,194,868 B2
Filed 11/10/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Accuracy of continuous glucose sensors | ||
|
Patent #
US 10,194,850 B2
Filed 07/14/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Methods and systems for early signal attenuation detection and processing | ||
|
Patent #
US 10,194,844 B2
Filed 03/04/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 10,201,301 B2
Filed 04/18/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing integrated analyte monitoring and infusion system therapy management | ||
|
Patent #
US 10,206,629 B2
Filed 04/28/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing data management in data monitoring system | ||
|
Patent #
US 10,206,611 B2
Filed 08/23/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems, devices, and methods for assembling an applicator and sensor control device | ||
|
Patent #
US 10,213,139 B2
Filed 05/13/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated analyte sensor and infusion device and methods therefor | ||
|
Patent #
US 10,220,145 B2
Filed 08/11/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Sensor inserter having introducer | ||
|
Patent #
US 10,226,207 B2
Filed 09/28/2013
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 10,231,654 B2
Filed 06/23/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US RE47,315 E1
Filed 06/30/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,261,069 B2
Filed 10/20/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing calibration of an analyte sensor in an analyte monitoring system | ||
|
Patent #
US 10,278,630 B2
Filed 11/30/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 10,292,632 B2
Filed 10/15/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing analyte sensor insertion | ||
|
Patent #
US 10,307,091 B2
Filed 10/20/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 10,327,638 B2
Filed 10/30/2017
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing glycemic control | ||
|
Patent #
US 10,327,682 B2
Filed 10/20/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Closed loop control system interface and methods | ||
|
Patent #
US 10,328,201 B2
Filed 10/30/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for dynamically updating calibration parameters for an analyte sensor | ||
|
Patent #
US 10,342,469 B2
Filed 12/08/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Integrated introducer and transmitter assembly and methods of use | ||
|
Patent #
US 10,342,489 B2
Filed 09/25/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Dropout detection in continuous analyte monitoring data during data excursions | ||
|
Patent #
US 10,345,291 B2
Filed 11/16/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing notification function in analyte monitoring systems | ||
|
Patent #
US 10,349,874 B2
Filed 08/31/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in medical communication system | ||
|
Patent #
US 10,349,877 B2
Filed 04/03/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and system for providing an integrated analyte sensor insertion device and data processing unit | ||
|
Patent #
US 10,362,972 B2
Filed 10/17/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Flexible patch for fluid delivery and monitoring body analytes | ||
|
Patent #
US 10,363,363 B2
Filed 01/06/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensing biointerface | ||
|
Patent #
US 10,376,188 B2
Filed 09/21/2017
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring system and methods for managing power and noise | ||
|
Patent #
US 10,429,250 B2
Filed 03/26/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Noise rejection methods and apparatus for sparsely sampled analyte sensor data | ||
|
Patent #
US 10,433,773 B1
Filed 03/13/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Smart messages and alerts for an infusion delivery and management system | ||
|
Patent #
US 10,448,834 B2
Filed 10/05/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 10,456,091 B2
Filed 11/05/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor calibration management | ||
|
Patent #
US 10,463,288 B2
Filed 08/11/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,463,310 B2
Filed 09/07/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 10,478,108 B2
Filed 02/05/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical devices and methods | ||
|
Patent #
US 10,492,685 B2
Filed 08/31/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Transcutaneous analyte sensor | ||
|
Patent #
US 10,524,703 B2
Filed 01/24/2014
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Advanced analyte sensor calibration and error detection | ||
|
Patent #
US 10,555,695 B2
Filed 07/02/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Systems and methods for display device and sensor electronics unit communication | ||
|
Patent #
US 10,561,349 B2
Filed 03/28/2017
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Advanced analyte sensor calibration and error detection | ||
|
Patent #
US 10,561,354 B2
Filed 07/02/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Systems and methods for display device and sensor electronics unit communication | ||
|
Patent #
US 10,568,552 B2
Filed 03/28/2017
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,610,137 B2
Filed 06/28/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,610,136 B2
Filed 06/28/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Advanced analyte sensor calibration and error detection | ||
|
Patent #
US 10,610,141 B2
Filed 09/27/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,610,135 B2
Filed 06/28/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and system for providing data communication in continuous glucose monitoring and management system | ||
|
Patent #
US 10,617,296 B2
Filed 01/07/2019
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,617,336 B2
Filed 06/28/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Device and method for automatic data acquisition and/or detection | ||
|
Patent #
US 10,617,823 B2
Filed 06/27/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Advanced analyte sensor calibration and error detection | ||
|
Patent #
US 10,624,568 B2
Filed 08/13/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,634,662 B2
Filed 11/05/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor on body unit | ||
|
Patent #
US D882,432 S1
Filed 04/18/2019
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte monitoring system and methods | ||
|
Patent #
US 10,653,317 B2
Filed 01/10/2019
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,653,344 B2
Filed 11/19/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Dropout detection in continuous analyte monitoring data during data excursions | ||
|
Patent #
US 10,656,139 B2
Filed 07/08/2019
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Methods and devices for analyte monitoring calibration | ||
|
Patent #
US 10,660,554 B2
Filed 03/08/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensing biointerface | ||
|
Patent #
US 10,667,729 B2
Filed 06/27/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensing biointerface | ||
|
Patent #
US 10,667,730 B2
Filed 10/16/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Compact medical device inserters and related systems and methods | ||
|
Patent #
US 10,674,944 B2
Filed 05/13/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Advanced analyte sensor calibration and error detection | ||
|
Patent #
US 10,682,084 B2
Filed 05/07/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Insulin delivery apparatuses capable of bluetooth data transmission | ||
|
Patent #
US 10,685,749 B2
Filed 12/28/2015
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensing biointerface | ||
|
Patent #
US 10,702,193 B2
Filed 01/14/2020
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,709,364 B2
Filed 11/21/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,709,362 B2
Filed 11/21/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,709,363 B2
Filed 11/21/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,716,498 B2
Filed 11/21/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,722,152 B2
Filed 11/05/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Advanced analyte sensor calibration and error detection | ||
|
Patent #
US 10,722,162 B2
Filed 09/27/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Introducer assembly and methods of use | ||
|
Patent #
US 10,736,547 B2
Filed 07/09/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,743,801 B2
Filed 11/21/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Continuous glucose monitoring system and methods of use | ||
|
Patent #
US 10,750,952 B2
Filed 03/26/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Interconnect for on-body analyte monitoring device | ||
|
Patent #
US 10,765,351 B2
Filed 08/10/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 10,772,547 B1
Filed 06/19/2020
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 10,772,572 B2
Filed 10/25/2019
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor and apparatus for insertion of the sensor | ||
|
Patent #
US 10,786,190 B2
Filed 01/07/2020
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,799,158 B2
Filed 11/21/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Systems and methods for display device and sensor electronics unit communication | ||
|
Patent #
US 10,799,157 B2
Filed 08/29/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,799,159 B2
Filed 02/13/2020
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,813,577 B2
Filed 02/13/2020
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 10,813,576 B2
Filed 11/21/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method and apparatus for providing data processing and control in a medical communication system | ||
|
Patent #
US 10,820,841 B2
Filed 08/09/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Methods and systems for early signal attenuation detection and processing | ||
|
Patent #
US 10,820,842 B2
Filed 06/18/2020
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Continuous analyte measurement systems and systems and methods for implanting them | ||
|
Patent #
US 10,827,954 B2
Filed 10/20/2017
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Advanced analyte sensor calibration and error detection | ||
|
Patent #
US 10,835,162 B2
Filed 09/27/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor control unit | ||
|
Patent #
US D902,408 S1
Filed 03/15/2019
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data | ||
|
Patent #
US 10,842,420 B2
Filed 03/02/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Analyte sensor device | ||
|
Patent #
US D903,877 S1
Filed 01/25/2019
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Remote monitoring of analyte measurements | ||
|
Patent #
US 10,856,736 B2
Filed 03/26/2020
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring and management device and method to analyze the frequency of user interaction with the device | ||
|
Patent #
US 10,856,785 B2
Filed 03/08/2018
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| System and methods for processing analyte sensor data for sensor calibration | ||
|
Patent #
US 10,856,787 B2
Filed 07/31/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Remote monitoring of analyte measurements | ||
|
Patent #
US 10,860,687 B2
Filed 06/23/2017
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Remote monitoring of analyte measurements | ||
|
Patent #
US 10,869,599 B2
Filed 03/26/2020
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Real time management of data relating to physiological control of glucose levels | ||
|
Patent #
US 10,872,102 B2
Filed 08/01/2014
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Devices, systems and methods for on-skin or on-body mounting of medical devices | ||
|
Patent #
US 10,874,338 B2
Filed 06/19/2020
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Multi-rate analyte sensor data collection with sample rate configurable signal processing | ||
|
Patent #
US 10,874,336 B2
Filed 10/12/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 10,881,341 B1
Filed 09/23/2020
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Medical device inserters and processes of inserting and using medical devices | ||
|
Patent #
US 10,881,340 B2
Filed 01/15/2016
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Systems and methods for display device and sensor electronics unit communication | ||
|
Patent #
US 10,881,335 B2
Filed 08/29/2019
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Displays for a medical device | ||
|
Patent #
US 10,881,355 B2
Filed 06/15/2020
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| IMPLANTABLE ANALYTE SENSOR | ||
|
Patent #
US 20100041971A1
Filed 10/29/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| COMPOSITE MATERIAL FOR IMPLANTABLE DEVICE | ||
|
Patent #
US 20100049024A1
Filed 10/30/2009
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Implantable analyte sensor | ||
|
Patent #
US 7,657,297 B2
Filed 05/03/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| IMPLANTABLE SENSOR METHOD AND SYSTEM | ||
|
Patent #
US 20090030297A1
Filed 09/16/2008
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Medtronic Minimed Incorporated
|
| EQUILIBRIUM NON-CONSUMING FLUORESCENCE SENSOR FOR REAL TIME INTRAVASCULAR GLUCOSE MEASUREMENT | ||
|
Patent #
US 20090018418A1
Filed 05/09/2008
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
GluMetrics Inc.
|
| DEVICE AND METHODS FOR CALIBRATING ANALYTE SENSORS | ||
|
Patent #
US 20090018426A1
Filed 05/09/2008
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
GluMetrics Inc.
|
| SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA | ||
|
Patent #
US 20090012379A1
Filed 08/20/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| ANALYTE SENSOR | ||
|
Patent #
US 20090036763A1
Filed 10/14/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES | ||
|
Patent #
US 20090045055A1
Filed 10/28/2008
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| POLYVIOLOGEN BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS | ||
|
Patent #
US 20090081803A1
Filed 07/11/2008
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
GluMetrics Inc.
|
| HPTS-MONO AND BIS CYS-MA POLYMERIZABLE FLUORESCENT DYES FOR USE IN ANALYTE SENSORS | ||
|
Patent #
US 20090061528A1
Filed 08/06/2008
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
GluMetrics Inc.
|
| SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA | ||
|
Patent #
US 20080021666A1
Filed 10/01/2007
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| SILICONE COMPOSITION FOR BIOCOMPATIBLE MEMBRANE | ||
|
Patent #
US 20080045824A1
Filed 06/14/2007
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Microneedle device for extraction and sensing of bodily fluids | ||
|
Patent #
US 7,344,499 B1
Filed 12/02/1999
|
Current Assignee
Valeritas LLC
|
Original Assignee
Georgia Tech Research Corporation
|
| Biointerface membrane with macro-and micro-architecture | ||
|
Patent #
US 7,364,592 B2
Filed 02/09/2005
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Electrochemical detection method and device | ||
|
Patent #
US 7,169,289 B2
Filed 02/10/2005
|
Current Assignee
November Aktiengesellschaft Gesellschaft Fur Molekulare Medizin
|
Original Assignee
November Aktiengesellschaft Gesellschaft Fur Molekulare Medizin
|
| Analyte sensor | ||
|
Patent #
US 20070027370A1
Filed 08/10/2006
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte sensor | ||
|
Patent #
US 20070045902A1
Filed 05/23/2006
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Porous membranes for use with implantable devices | ||
|
Patent #
US 7,192,450 B2
Filed 08/22/2003
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Method of manufacturing electrochemical sensors | ||
|
Patent #
US 7,225,535 B2
Filed 09/12/2003
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Abbott Diabetes Care Incorporated
|
| Minimally invasive detecting device | ||
|
Patent #
US 6,091,975 A
Filed 04/01/1998
|
Current Assignee
ALZA Corporation
|
Original Assignee
ALZA Corporation
|
| Multi-barbed device for retaining tissue in apposition and methods of use | ||
|
Patent #
US 6,991,643 B2
Filed 12/20/2000
|
Current Assignee
Vahid Saadat
|
Original Assignee
USGI Medical Inc.
|
| SYSTEMS AND METHODS FOR MANUFACTURE OF AN ANALYTE-MEASURING DEVICE INCLUDING A MEMBRANE SYSTEM | ||
|
Patent #
US 20060015020A1
Filed 07/06/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| TRANSCUTANEOUS ANALYTE SENSOR | ||
|
Patent #
US 20060016700A1
Filed 06/21/2005
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Methods of determining concentration of glucose | ||
|
Patent #
US 7,058,437 B2
Filed 04/17/2003
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Therasense Incorporated
|
| System and method for object tracking | ||
|
Patent #
US 20050026689A1
Filed 08/26/2004
|
Current Assignee
Sony Interactive Entertainment Inc.
|
Original Assignee
Sony Interactive Entertainment Inc.
|
| Tissue implantable sensors for measurement of blood solutes | ||
|
Patent #
US 20050059871A1
Filed 10/31/2003
|
Current Assignee
Regents of the University of California
|
Original Assignee
Regents of the University of California
|
| Device and method for determining analyte levels | ||
|
Patent #
US 6,862,465 B2
Filed 07/27/2001
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Real time self-adjusting calibration algorithm | ||
|
Patent #
US 6,895,263 B2
Filed 05/08/2002
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Medtronic Minimed Incorporated
|
| Sensor head for use with implantable devices | ||
|
Patent #
US 20050103625A1
Filed 12/22/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Minimally-invasive system and method for monitoring analyte levels | ||
|
Patent #
US 20050096519A1
Filed 08/02/2004
|
Current Assignee
Becton Dickinson Co
|
Original Assignee
John D. Denuzzio, William E. Strohben Jr
|
| Method of reducing the effect of direct and mediated interference current in an electrochemical test strip | ||
|
Patent #
US 20050139489A1
Filed 10/29/2004
|
Current Assignee
LifeScan Scotland Limited
|
Original Assignee
LifeScan Scotland Limited
|
| Calibration techniques for a continuous analyte sensor | ||
|
Patent #
US 20050143635A1
Filed 12/03/2004
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 20050121322A1
Filed 01/24/2005
|
Current Assignee
Therasense Incorporated
|
Original Assignee
Therasense Incorporated
|
| Minimally-invasive system and method for monitoring analyte levels | ||
|
Patent #
US 20040015063A1
Filed 12/21/2001
|
Current Assignee
Becton Dickinson Co
|
Original Assignee
Becton Dickinson Co
|
| Method of making a kink-resistant catheter | ||
|
Patent #
US 6,702,972 B1
Filed 08/23/2000
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
DIAMETRICS MEDICAL LIMITED
|
| Porous polymeric membrane toughened composites | ||
|
Patent #
US 6,737,158 B1
Filed 10/30/2002
|
Current Assignee
W. L. Gore Associates
|
Original Assignee
Gore Enterprise Holdings Incorporated
|
| Membrane for use with implantable devices | ||
|
Patent #
US 20030023317A1
Filed 07/27/2001
|
Current Assignee
DexCom Incorporated
|
Original Assignee
DexCom Incorporated
|
| Systems and methods for treatment of coronary artery disease | ||
|
Patent #
US 20030036773A1
Filed 08/02/2002
|
Current Assignee
Cardiac Pacemakers Incorporated
|
Original Assignee
Cardiac Pacemakers Incorporated
|
| Multi-component polymeric networks containing poly(ethylene glycol) | ||
|
Patent #
US 6,528,584 B2
Filed 04/12/2001
|
Current Assignee
University of Akron
|
Original Assignee
University of Akron
|
| Biocompatible medical articles and process for their production | ||
|
Patent #
US 20030059631A1
Filed 09/23/2002
|
Current Assignee
Bayer Materialscience AG
|
Original Assignee
Phylogenetix Laboratories Inc.
|
| Glucose sensor | ||
|
Patent #
US 6,546,268 B1
Filed 06/02/2000
|
Current Assignee
Ball Semiconductor Inc.
|
Original Assignee
Ball Semiconductor Inc.
|
| Method and system for non-vascular sensor implantation | ||
|
Patent #
US 20030078560A1
Filed 12/27/2001
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Medtronic Minimed Incorporated
|
| Analyte monitoring device and methods of use | ||
|
Patent #
US 6,565,509 B1
Filed 09/21/2000
|
Current Assignee
Abbott Diabetes Care Incorporated
|
Original Assignee
Therasense Incorporated
|
| Handheld personal data assistant (PDA) with a medical device and method of using the same | ||
|
Patent #
US 6,558,320 B1
Filed 01/20/2000
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Medtronic Minimed Incorporated
|
| Fuel cell type reactor and method for producing a chemical compound by using the same | ||
|
Patent #
US 6,569,309 B2
Filed 10/09/2001
|
Current Assignee
Asahi Kasei Chemicals Corporation
|
Original Assignee
Asahi Kasei Kabushiki Kaisha
|
| Implantable glucose sensor | ||
|
Patent #
US 6,343,225 B1
Filed 09/14/1999
|
Current Assignee
Arbmetrics LLC
|
Original Assignee
Implanted Biosystems Incorporated
|
| Glucose sensor package system | ||
|
Patent #
US 6,360,888 B1
Filed 02/10/2000
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Minimed Inc.
|
| Generic integrated implantable potentiostat telemetry unit for electrochemical sensors | ||
|
Patent #
US 6,366,794 B1
Filed 11/19/1999
|
Current Assignee
University of Connecticut, PRECISION CONTROL DESIGN INC.
|
Original Assignee
University of Connecticut
|
| Reusable analyte sensor site and method of using the same | ||
|
Patent #
US 6,368,274 B1
Filed 05/08/2000
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Medtronic Minimed Incorporated
|
| Reusable analyte sensor site and method of using the same | ||
|
Patent #
US 20020055673A1
Filed 12/21/2001
|
Current Assignee
Minimed Inc.
|
Original Assignee
Minimed Inc.
|
| Connecting structure for exhaust pipes | ||
|
Patent #
US 6,406,066 B1
Filed 11/13/2000
|
Current Assignee
Honda Giken Kogyo Kabushiki Kaisha
|
Original Assignee
Honda Giken Kogyo Kabushiki Kaisha
|
| Glucose monitor calibration methods | ||
|
Patent #
US 6,424,847 B1
Filed 02/23/2000
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Medtronic Minimed Incorporated
|
| Biosensor | ||
|
Patent #
US 6,268,161 B1
Filed 05/11/1999
|
Current Assignee
M-Biotech Inc.
|
Original Assignee
M-Biotech Inc.
|
| Biosensor | ||
|
Patent #
US 6,059,946 A
Filed 04/13/1998
|
Current Assignee
Panasonic Healthcare Holdings Co. Ltd.
|
Original Assignee
Matsushita Electric Industrial Company Limited
|
| Implantable enzyme-based monitoring systems adapted for long term use | ||
|
Patent #
US 6,081,736 A
Filed 10/20/1997
|
Current Assignee
Alfred E. Mann Foundation For Scientific Research
|
Original Assignee
Alfred E. Mann Foundation For Scientific Research
|
| Battery having a built-in controller | ||
|
Patent #
US 6,074,775 A
Filed 04/02/1998
|
Current Assignee
Board of Trustees of the University of Illinois
|
Original Assignee
Procter Gamble Company
|
| Electrochemical sensor and integrity tests therefor | ||
|
Patent #
US 6,088,608 A
Filed 10/20/1997
|
Current Assignee
Alfred E. Mann Foundation For Scientific Research
|
Original Assignee
Alfred E. Mann Foundation For Scientific Research
|
| Electrochemical cells | ||
|
Patent #
US 5,863,400 A
Filed 02/24/1997
|
Current Assignee
Lifescan Incorporated
|
Original Assignee
USF Filtration Separations Group Inc.
|
| Polyurethane/polyurea compositions containing silicone for biosensor membranes | ||
|
Patent #
US 5,882,494 A
Filed 08/28/1995
|
Current Assignee
Minimed Inc.
|
Original Assignee
Minimed Inc.
|
| Implantable sensor employing an auxiliary electrode | ||
|
Patent #
US 5,914,026 A
Filed 01/06/1997
|
Current Assignee
Tenax Therapeutics Inc.
|
Original Assignee
Implanted Biosystems Incorporated
|
| Blood glucose monitoring system | ||
|
Patent #
US 5,743,262 A
Filed 06/07/1995
|
Current Assignee
Cercacor Laboratories
|
Original Assignee
Masimo Corporation
|
| Chemical signal-impermeable mask | ||
|
Patent #
US 5,735,273 A
Filed 09/12/1995
|
Current Assignee
Animas Technologies LLC
|
Original Assignee
Cygnus Inc.
|
| Electrochemical biosensors | ||
|
Patent #
US 5,776,324 A
Filed 05/17/1996
|
Current Assignee
Pioneer Surgical Technology Incorporated
|
Original Assignee
Encelle Inc.
|
| Nano-porous PTFE biomaterial | ||
|
Patent #
US 5,480,711 A
Filed 07/12/1994
|
Current Assignee
Bridger Biomed Inc.
|
Original Assignee
Bruce G. Ruefer
|
| Electrochemical sensors | ||
|
Patent #
US 5,494,562 A
Filed 06/27/1994
|
Current Assignee
Siemens Healthcare Diagnostics Incorporated
|
Original Assignee
CIBA Vision Corporation
|
| Glucose monitoring system | ||
|
Patent #
US 5,497,772 A
Filed 11/19/1993
|
Current Assignee
MANN ALFRED E. FOUNDATION FOR SCIENTIFIC RESEARCH
|
Original Assignee
Alfred E. Mann Foundation For Scientific Research
|
| Sensing elements and methods for uniformly making individual sensing elements | ||
|
Patent #
US 5,508,509 A
Filed 11/30/1993
|
Current Assignee
Terumo Cardiovascular Systems Corporation
|
Original Assignee
3M Company
|
| Analytical system for monitoring a substance to be analyzed in patient-blood | ||
|
Patent #
US 5,507,288 A
Filed 05/03/1995
|
Current Assignee
Boehringer Mannheim GmbH
|
Original Assignee
Boehringer Mannheim GmbH
|
| Extended use planar sensors | ||
|
Patent #
US 5,518,601 A
Filed 08/24/1995
|
Current Assignee
Novartis Ag
|
Original Assignee
CIBA Vision Corporation
|
| Implantable sensor chip | ||
|
Patent #
US 5,513,636 A
Filed 08/12/1994
|
Current Assignee
CB-CARMEL BIOTECHNOLOGY LTD.
|
Original Assignee
CB-CARMEL BIOTECHNOLOGY LTD.
|
| Sensor devices | ||
|
Patent #
US 5,531,878 A
Filed 02/17/1995
|
Current Assignee
The Victoria University of Manchester
|
Original Assignee
The Victoria University of Manchester
|
| Transcutaneous sensor insertion set | ||
|
Patent #
US 5,390,671 A
Filed 03/15/1994
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Minimed Inc.
|
| Method of fabricating thin film sensors | ||
|
Patent #
US 5,391,250 A
Filed 03/15/1994
|
Current Assignee
Medtronic Minimed Incorporated
|
Original Assignee
Minimed Inc.
|
| Method and system for determining bioactive substances | ||
|
Patent #
US 5,411,866 A
Filed 03/30/1993
|
Current Assignee
National Research Council Canada
|
Original Assignee
National Research Council Canada
|
| Method of making and amperometric electrodes | ||
|
Patent #
US 5,429,735 A
Filed 06/27/1994
|
Current Assignee
BAAYER CORPORATION
|
Original Assignee
Miles Inc.
|
| Chemically wired fructose dehydrogenase electrodes | ||
|
Patent #
US 5,298,144 A
Filed 09/15/1992
|
Current Assignee
YSI Incorporated
|
Original Assignee
THE YELLOW SPRINGS INSTRUMENT COMPANY INC.
|
| Apparatus and method for implantation of sensors | ||
|
Patent #
US 5,299,571 A
Filed 01/22/1993
|
Current Assignee
Disetronic Licensing Ag
|
Original Assignee
Eli Lilly and Company
|
| Measurement of electrocardiographic wave and sphygmus | ||
|
Patent #
US 5,316,008 A
Filed 04/03/1991
|
Current Assignee
Casio Computer Company
|
Original Assignee
Casio Computer Company
|
| Thin film implantable electrode and method of manufacture | ||
|
Patent #
US 5,324,322 A
Filed 04/20/1992
|
Current Assignee
Case Western Reserve University
|
Original Assignee
Case Western Reserve University
|
| Electronic apparatus | ||
|
Patent #
US 5,331,555 A
Filed 05/09/1991
|
Current Assignee
Sharp Electronics Corporation
|
Original Assignee
Sharp Electronics Corporation
|
| Conductive sensors and their use in diagnostic assays | ||
|
Patent #
US 5,202,261 A
Filed 11/18/1991
|
Current Assignee
Miles Inc.
|
Original Assignee
Miles Inc.
|
| Electrochemical biosensor based on immobilized enzymes and redox polymers | ||
|
Patent #
US 5,089,112 A
Filed 01/11/1990
|
Current Assignee
Brookhaven Science Associates LLC
|
Original Assignee
Associated Universities Inc.
|
| Thin film electrical component | ||
|
Patent #
US 5,108,819 A
Filed 02/14/1990
|
Current Assignee
Disetronic Licensing Ag
|
Original Assignee
Eli Lilly and Company
|
| Sterilizing dressing device and method for skin puncture | ||
|
Patent #
US 4,988,341 A
Filed 06/05/1989
|
Current Assignee
Clinical Diagnostic Systems Inc.
|
Original Assignee
Eastman Kodak Company
|
| Continuous glucose monitoring and a system utilized therefor | ||
|
Patent #
US 4,890,621 A
Filed 01/19/1988
|
Current Assignee
NORTH-STAR RESEARCH INSTITUTE LTD. A CORP. OF DE
|
Original Assignee
NORTHSTAR RESEARCH INSTITUTE LTD.
|
| Implantable electrochemical sensor | ||
|
Patent #
US 4,919,141 A
Filed 01/04/1988
|
Current Assignee
INSTITUT FUR DIABETESTECHNOLOGIE GEMEINNUTZIGE FORSCHUNGS - UND ENTWICKLUNGSGESELLSCHAFT MBH
|
Original Assignee
Institute fur Diabetestechnologie Gemeinnutzige Forschungs- und Entwicklungsgesellschaft mbH
|
| Sphenoidal electrode and insertion method | ||
|
Patent #
US 4,805,625 A
Filed 07/08/1987
|
Current Assignee
AD-Tech Medical Instrument Corp.
|
Original Assignee
AD-Tech Medical Instrument Corp.
|
| Low-potential electrochemical redox sensors | ||
|
Patent #
US 4,805,624 A
Filed 04/14/1987
|
Current Assignee
PITTSBURGH MEDICAL CENTER UNIVERSITY OF
|
Original Assignee
THE MONTEFIORE HOSPITAL ASSOCIATION OF WESTERN PA
|
| Patient-operated glucose monitor and diabetes management system | ||
|
Patent #
US 4,731,726 A
Filed 05/19/1986
|
Current Assignee
Roche Diabetes Care Inc.
|
Original Assignee
HealthWare Corporation
|
| Method and membrane applicable to implantable sensor | ||
|
Patent #
US 4,650,547 A
Filed 12/20/1985
|
Current Assignee
Regents of the University of California
|
Original Assignee
Regents of the University of California
|
| Implantable gas-containing biosensor and method for measuring an analyte such as glucose | ||
|
Patent #
US 4,680,268 A
Filed 09/18/1985
|
Current Assignee
Childrens Hospital Medical Center
|
Original Assignee
Childrens Hospital Medical Center
|
| Flash photographing system | ||
|
Patent #
US 4,494,850 A
Filed 06/16/1983
|
Current Assignee
Canon Kabushiki Kaisha
|
Original Assignee
Canon Kabushiki Kaisha
|
| Electrochemical detection cell | ||
|
Patent #
US RE31,916 E
Filed 04/29/1981
|
Current Assignee
National Draeger Inc.
|
Original Assignee
Becton Dickinson Co
|
| Electrode for living bodies | ||
|
Patent #
US 4,442,841 A
Filed 04/30/1981
|
Current Assignee
Mitsubishi Rayon Company Limited
|
Original Assignee
Mitsubishi Rayon Company Limited
|
| Implantable temperature probe | ||
|
Patent #
US 4,253,469 A
Filed 04/20/1979
|
Current Assignee
Lockheed Martin Corporation
|
Original Assignee
The Narda Microwave Corp.
|
| Hydrophilic contact lens made from polysiloxanes which are thermally bonded to polymerizable groups and which contain hydrophilic sidechains | ||
|
Patent #
US 4,260,725 A
Filed 12/10/1979
|
Current Assignee
Bausch Lomb Incorporated
|
Original Assignee
Bausch Lomb Incorporated
|
| Disposable physiological telemetric device | ||
|
Patent #
US 3,943,918 A
Filed 12/02/1971
|
Current Assignee
Tel-Pac Inc.
|
Original Assignee
TEL-PAC INC.
|
| ELECTROCHEMICAL CELL | ||
|
Patent #
US 3,791,871 A
Filed 04/14/1971
|
Current Assignee
Lockheed Martin Space Operations Company
|
Original Assignee
Lockheed Aircraft Corporation
|
10 Claims
-
1. A method for implanting an analyte sensor in a host, the method comprising:
-
forming a precisely dimensioned pocket in a subcutaneous space of a host, wherein the pocket is dimensioned no greater than dimensions of an analyte sensor; and inserting the analyte sensor into the precisely dimensioned pocket so as to minimize movement of the sensor within the pocket. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
1 Specification
This application is a division of U.S. application Ser. No. 10/838,912, filed May 3, 2004, the contents of which is hereby incorporated by reference herein in its entirety.
The present invention relates generally to systems and methods for making and using an implantable analyte sensor.
Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which may cause an array of physiological derangements (for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye) associated with the deterioration of small blood vessels. A hypoglycemic reaction (low blood sugar) may be induced by an inadvertent overdose of insulin, or after a normal dose of insulin or glucose-lowering agent accompanied by extraordinary exercise or insufficient food intake.
Conventionally, a diabetic person carries a self-monitoring blood glucose (SMBG) monitor, which typically comprises uncomfortable finger pricking methods. Due to the lack of comfort and convenience, a diabetic will normally only measure his or her glucose level two to four times per day. Unfortunately, these time intervals are so far spread apart that the diabetic will likely find out too late, sometimes incurring dangerous side effects, of a hyper- or hypo-glycemic condition. In fact, it is not only unlikely that a diabetic will take a timely SMBG value, but the diabetic will not know if their blood glucose value is going up (higher) or down (lower) based on conventional methods, inhibiting their ability to make educated insulin therapy decisions.
The prior art discloses a variety of analyte sensors that provide complex, short-term, transcutaneous, or partially implantable analyte sensors. Unfortunately, each of these sensors suffers from various disadvantages, such as lack of continuous care (short-term sensors), discomfort (transcutaneous and partially implantable sensors), and inconvenience (sensors with multiple components).
There is a need for a device a long-term, implantable analyte sensor that functions accurately and reliably, to provide improved patient convenience and care.
Accordingly, in a first embodiment, an implantable analyte sensor for measuring an analyte in a host is provided, the sensor including: a sensor body including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host; a first biointerface material adjacent to the sensing region, wherein the first biointerface material includes a porous architecture that promotes vascularized tissue ingrowth and interferes with barrier cell layer formation, for allowing analyte transport to the sensing region in vivo; and a second biointerface material adjacent to at least a portion of the non-sensing region, wherein the second biointerface material includes a porous architecture that promotes tissue ingrowth for anchoring the sensor in vivo.
In an aspect of the first embodiment, the first biointerface material further includes a domain proximal to the sensing region that is impermeable to cells or cell processes and is permeable to the passage of the analyte.
In an aspect of the first embodiment, the second biointerface material and the first biointerface material include porous silicone, and wherein first biomaterial material includes porous silicone with a through porosity substantially across the entire material.
In an aspect of the first embodiment, the sensing region is on a first surface of the sensor body, and wherein the sensor body includes a second surface opposite the first surfaces, and wherein the second biointerface material is disposed on a substantial portion of the first and second surfaces of the sensor body.
In a second embodiment, an analyte sensor for short-term and long-term immobilization in a host'"'"'s soft tissue is provided, the sensor including: a short-term anchoring mechanism for providing immobilization of the sensor in the soft tissue prior to substantial formation of the foreign body capsule; and a long-term anchoring mechanism for providing immobilization of the sensor in the soft tissue during and after substantial formation of the foreign body capsule.
In an aspect of the second embodiment, the short-term anchoring mechanism includes a suture tab on the sensor body. In an aspect of the second embodiment, the short-term anchoring mechanism includes a suture. In an aspect of the second embodiment, the short-term anchoring mechanism includes at least one of prongs, spines, barbs, wings, and hooks. In an aspect of the second embodiment, the short-term anchoring mechanism includes a geometric configuration of the sensor body. In an aspect of the second embodiment, the geometric configuration includes at least one of a helical, tapered, and winged configuration.
In an aspect of the second embodiment, the long-term anchoring mechanism includes an anchoring material disposed on the sensor body. In an aspect of the second embodiment, the anchoring material includes a fibrous material. In an aspect of the second embodiment, the anchoring material includes a porous material. In an aspect of the second embodiment, the anchoring material includes a material with a surface topography. In an aspect of the second embodiment, the long-term anchoring mechanism includes a surface topography formed on an outer surface of the sensor body.
In a third embodiment, a method for immobilizing an analyte sensor in soft tissue is provided, the method including: implanting the analyte sensor in a host; anchoring the sensor in the host prior to formation of a foreign body capsule for at least short-term immobilization of the sensor within the soft tissue of the host; and anchoring the sensor within the foreign body capsule for long-term immobilization of the sensor within the soft tissue of the host.
In an aspect of the third embodiment, the short-term immobilization step includes suturing the sensor to the host'"'"'s tissue. In an aspect of the third embodiment, the suturing step includes suturing the sensor such that the sensor is in compression. In an aspect of the third embodiment, the short term immobilization step includes utilizing at least one of prongs, spines, barbs, wings, and hooks on the sensor to anchor the sensor into the host'"'"'s tissue upon implantation.
In an aspect of the third embodiment, the long-term immobilization step includes disposing an anchoring material on the sensor body that allows host tissue ingrowth into the material. In an aspect of the third embodiment, the anchoring material includes a fibrous material. In an aspect of the third embodiment, the anchoring material includes a porous material. In an aspect of the third embodiment, the anchoring material includes a material with a surface topography. In an aspect of the third embodiment, the long-term immobilization step includes utilizing a surface topography formed on an outer surface of the sensor body that allows tissue ingrowth into the surface of the sensor body.
In a fourth embodiment, a method for continuous measurement of an analyte in a host is provided, the method including: implanting an analyte sensor in a host; and measuring the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor.
In an aspect of the fourth embodiment, the analyte sensor is wholly implanted into the host. In an aspect of the fourth embodiment, the method further includes explanting the analyte sensor from the host. In an aspect of the fourth embodiment, the method further includes implanting another analyte sensor in the host. In an aspect of the fourth embodiment, the another analyte sensor is wholly implanted into the host.
In an aspect of the fourth embodiment, the method further includes anchoring the analyte sensor in the host prior to formation of a foreign body capsule for at least short-term immobilization of the sensor within the soft tissue of the host. In an aspect of the fourth embodiment, the method further includes anchoring the sensor within the foreign body capsule for long-term immobilization of the sensor within the soft tissue of the host.
In a fifth embodiment, a method for implantation of an analyte sensor in a host is provided, the method including: forming a precisely dimensioned pocket in the subcutaneous space of the host, wherein the pocket is dimensioned no greater than the dimensions of the analyte sensor; inserting the analyte sensor into the precisely-dimensioned pocket so as to minimize movement of the sensor within the pocket.
In an aspect of the fifth embodiment, the step of forming a pocket includes using a tool that allows precise dimensioning of the pocket. In an aspect of the fifth embodiment, the tool includes a head dimensioned substantially similar to the dimensions of the analyte sensor and a handle for guiding the head into the pocket. In an aspect of the fifth embodiment, the tool includes a head dimensioned smaller than the dimensions of the analyte sensor and a handle for guiding the head into the pocket.
In an aspect of the fifth embodiment, the method further includes suturing the analyte sensor to the host tissue.
In an aspect of the fifth embodiment, the pocket is formed adjacent the fascia of the host. In an aspect of the fifth embodiment, the analyte sensor includes a sensing region for measuring an analyte concentration, and wherein the analyte sensor is placed within the pocket such that the sensing region is located adjacent to the fascia.
In an aspect of the fifth embodiment, the method further includes a step of forming a vertical incision prior to the step of forming a pocket. In an aspect of the fifth embodiment, the method further includes a step of forming a horizontal incision prior to the step of forming a pocket. In an aspect of the fifth embodiment, the pocket is formed in the abdominal region of the host.
In a sixth embodiment, an implantable analyte sensor for measuring an analyte concentration in a host is provided, the sensor including: a sensor body substantially formed from a water vapor permeable material; and electrical components encapsulated within the sensor body, wherein the electrical components include RF circuitry and an antenna adapted for RF transmission from the sensor in vivo to a receiver ex vivo, wherein the RF circuitry is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor in vivo to the receiver ex vivo.
In an aspect of the sixth embodiment, the fixed distance includes a configuration that reduces water permeability therein. In an aspect of the sixth embodiment, the configuration includes conformal coating. In an aspect of the sixth embodiment, the conformal coating includes Parylene.
In an aspect of the sixth embodiment, the configuration includes epoxy. In an aspect of the sixth embodiment, the configuration includes glass. In an aspect of the sixth embodiment, the configuration includes one or more hermetic containers.
In a seventh embodiment, an analyte sensor for RF transmission between the analyte sensor in vivo and a receiver ex vivo is provided, the sensor including: a sensor body including RF circuitry encapsulated within a substantially water vapor permeable body that enables RF transmission therethrough; a sensing region located on an outer surface of the sensor body for measuring an analyte in soft tissue; a biointerface material disposed adjacent to the sensing region that supports vascularized tissue ingrowth for transport of the analyte to the sensing region; and an anchoring material on a non-sensing outer surface of the sensor body that supports tissue ingrowth for immobilization of the sensor body in soft tissue.
In an aspect of the seventh embodiment, the sensor further includes an antenna encapsulated within the sensor body. In an aspect of the seventh embodiment, the sensor further includes a power source encapsulated within the sensor body.
In an aspect of the seventh embodiment, the sensor body is formed from plastic. In an aspect of the seventh embodiment, the plastic includes epoxy.
In an aspect of the seventh embodiment, the sensor body is molded around the RF circuitry. In an aspect of the seventh embodiment, the sensor further includes an electrode system exposed at the sensing region. In an aspect of the seventh embodiment, the electrode system extends through the water vapor permeable body and is operably connected to the RF circuitry.
In an aspect of the seventh embodiment, the biointerface material includes a solid portion with a plurality of interconnected cavities. In an aspect of the seventh embodiment, the biointerface material further includes a domain proximal to the sensing region that is impermeable to cells or cell processes and is permeable to the passage of the analyte.
In an eighth embodiment, an electrochemical analyte sensor for measuring an analyte concentration is provided, the sensor including: a sensor body including electronic circuitry encapsulated within the sensor body; and a plurality of electrodes that extend from an outer surface of the sensor body to the encapsulated electronic circuitry, wherein the electrodes are mechanically and electrically connected and aligned to the electronic circuitry prior to encapsulation within the sensor body.
In an aspect of the eighth embodiment, the electrodes are swaged to the electronic circuitry. In an aspect of the eighth embodiment, the electrodes are welded using a technique selected from the group consisting of spot welding, ultrasonic welding, and laser welding.
In an aspect of the eighth embodiment, the electrodes and electronic circuitry are encapsulated in the sensor body by a molding process. In an aspect of the eighth embodiment, the sensor body includes a water vapor permeable material.
In an aspect of the eighth embodiment, the electronic circuitry is spaced from the water vapor permeable sensor body, such that water vapor penetration within a fixed distance from the electronic circuitry is inhibited. In an aspect of the eighth embodiment, the electronic circuitry is spaced from the water vapor permeable sensor body by epoxy. In an aspect of the eighth embodiment, the electronic circuitry is spaced from the water vapor permeable sensor body by a glass tube. In an aspect of the eighth embodiment, the electronic circuitry is spaced from the water vapor permeable sensor body by Parylene. In an aspect of the eighth embodiment, the electronic circuitry is spaced from the water vapor permeable sensor body by one or more hermetic containers.
In an aspect of the eighth embodiment, the sensor body includes a substantially seamless exterior with the electrodes extending through the sensor body to the outer surface thereof.
In a ninth embodiment, a method for manufacturing an electrochemical analyte sensor is provided, the method including: providing electronic circuitry designed to process signals from the sensor; swaging a plurality of electrodes to the electronic circuitry; and molding a plastic material around the electronic circuitry to form the sensor body.
In a tenth embodiment, a method for manufacturing an analyte sensor is provided, the method including: providing sensor electronics designed to process signals from the sensor; conformally coating the sensor electronics with a material that has a first water permeability rate; and molding a water vapor permeable material that has a second water permeability rate around the coated sensor electronics to form a substantially seamless sensor body, wherein the second water permeability rate is greater than the first water penetration rate.
In an aspect of the tenth embodiment, the molding includes a two-step molding process to form the substantially seamless sensor body.
In an aspect of the tenth embodiment, the two-step molding process includes: holding a first portion of the coated sensor electronics and molding around a second portion of the coated sensor electronics; and holding a portion of the cured sensor body and molding around the first portion of the coated sensor electronics.
In an eleventh embodiment, a method for manufacturing a multilayer membrane for an analyte sensor is provided, the method including: serially casting and subsequently curing each of a plurality of layers to form the multilayer membrane onto a liner, wherein the layers include a resistance layer for limiting the passage of an analyte and an enzyme layer including an enzyme for reacting with the analyte; and releasing the multilayer membrane from the liner for application onto the analyte sensor.
In an aspect of the eleventh embodiment, the multilayer membrane further includes an interference layer that substantially prevents passage of potentially electrochemically interfering substances.
In an aspect of the eleventh embodiment, the multilayer membrane further includes an electrolyte layer including a hydrogel for maintaining hydrophilicity at electrochemically reactive surfaces of the analyte sensor.
In a twelfth embodiment, a method for casting a membrane that regulates the transport of glucose, the method including: forming a solvent solution including a polymer blend and a solvent, wherein the polymer blend includes hydrophilic and hydrophobic components; maintaining the solution at a first elevated temperature for a predetermined time period in order to mix the hydrophilic and hydrophobic components with each other and the solvent, wherein the elevated temperature is above room temperature; applying the composition to a liner to form a film thereon; and curing the film, wherein the curing is accomplished while ramping the temperature at a predetermined ramp rate to a second elevated temperature that is above the first temperature.
In an aspect of the twelfth embodiment, the first elevated temperature is between about 60° C. and about 100° C. In an aspect of the twelfth embodiment, the first elevated temperature is about 80° C.
In an aspect of the twelfth embodiment, the predetermined time period is at least about 24 hours. In an aspect of the twelfth embodiment, the predetermined time period is at least about 44 hours.
In an aspect of the twelfth embodiment, the predetermined ramp rate is between about 3° C. per minute and 12° C. per minute. In an aspect of the twelfth embodiment, the predetermined ramp rate is about 7° C. per minute.
In an aspect of the twelfth embodiment, the second elevated temperature is at least about 100° C.
In a thirteenth embodiment, a method for casting a membrane for use with an electrochemical glucose sensor is provided, wherein the membrane substantially prevents passage of potentially electrochemically interfering substances, the method including: forming a sufficiently diluted solvent solution including a polymer and a solvent, wherein sufficiently diluted solvent solution includes a ratio of polymer to solvent of about 1 to 10 wt. % polymer to about 90 to 99 wt. % solvent; and applying the solvent solution at a sufficiently fast casting speed that substantially avoids film thickness inhomogeneities due to evaporation during casting of the sufficiently diluted solvent solution.
In an aspect of the thirteenth embodiment, the membrane limits the diffusion of hydrophilic species and large molecular weight species.
In an aspect of the thirteenth embodiment, the membrane includes a thickness between about 0.1 and 5 microns. In an aspect of the thirteenth embodiment, the membrane includes a thickness between about 0.5 and 3 microns.
In an aspect of the thirteenth embodiment, the polymer includes polyurethane.
In an aspect of the thirteenth embodiment, the sufficiently fast casting speed is between about 8 to about 15 inches/second. In an aspect of the thirteenth embodiment, the sufficiently fast casting speed is about 11.5 inches/second.
In a fourteenth embodiment, an implantable analyte sensor is provided, the sensor including: a body including a material which is permeable to water vapor, the body further including a sensing region for measuring levels of an analyte; and a transmitter within the body for transmitting the measurements obtained by the sensing region, wherein at least a portion of the transmitter is spaced from the body by a material adapted to reduce water from penetrating therein.
In an aspect of the fourteenth embodiment, the transmitter includes an oscillator and at least a portion of the oscillator is spaced from the body by the material adapted to inhibit fluid from penetrating therein. In an aspect of the fourteenth embodiment, the oscillator includes an inductor and wherein the inductor is spaced from the body by the material adapted to inhibit fluid from penetrating therein. In an aspect of the fourteenth embodiment, the oscillator includes a voltage controlled oscillator.
In a fifteenth embodiment, an implantable analyte sensor is provided, including: electronics encapsulated within a water vapor permeable body, wherein the electronics include a microprocessor module and an RF module that has an RF transceiver with a phase-locked loop, and wherein the microprocessor module is programmed to initiate re-calibration of the PLL responsive to detection of off-frequency shift.
In an aspect of the fifteenth embodiment, an electrochemical glucose sensor including a three-electrode system, the sensor including: an electrochemical cell including a working electrode, reference electrode, and counter electrode; and a potentiostat that controls the potential between the working and reference electrodes, wherein an allowable range for the counter electrode voltage is set sufficiently wide such that the glucose sensor can react with other reducible species when oxygen becomes limited and sufficiently narrow to ensure the circuitry does not allow excessive current draw or bubble formation to occur.
In an aspect of the fifteenth embodiment, limiting the current of at least one of the working or counter electrode amplifiers to a preset current value configures the allowable range. In an aspect of the fifteenth embodiment, setting the op-amp to be offset from battery ground configures the allowable range. In an aspect of the fifteenth embodiment, a reference voltage setting between about +0.6V and +0.8V with respect to battery ground configures the allowable range. In an aspect of the fifteenth embodiment, a reference voltage setting of about +0.7V with respect to battery ground configures the allowable range.
In a sixteenth embodiment, a method for manufacturing an analyte sensor is provided, the method including: providing a sensor body, wherein the sensor body includes a sensing region for measuring the analyte; forming a multilayer membrane on a liner; releasing the multilayer membrane from the liner and onto the sensor body; and attaching the multilayer membrane to the analyte sensor body proximal to the sensing region.
In an aspect of the sixteenth embodiment, the attaching step includes a mechanical attachment. In an aspect of the sixteenth embodiment, the mechanical attachment includes a metal or plastic O-ring adapted to fit around a raised sensing region. In an aspect of the sixteenth embodiment, the mechanical attachment includes a metal or plastic disc adapted to be press-fit into the sensor body. In an aspect of the sixteenth embodiment, the mechanical attachment includes a metal or plastic clip adapted to be snap-fit into the sensor body.
In a seventeenth embodiment, a method for manufacturing an analyte sensor is provided, the method including: providing a sensor body, wherein the sensor body includes a sensing region for measuring the analyte; forming a multilayer membrane on a liner; releasing the multilayer membrane from the liner and placing onto the sensor body; and attaching the multilayer membrane to the analyte sensor body proximal to the sensing region.
In an aspect of the seventeenth embodiment, the attaching step includes a mechanical attachment. In an aspect of the seventeenth embodiment, the mechanical attachment includes a metal or plastic O-ring adapted to fit around a raised sensing region. In an aspect of the seventeenth embodiment, the mechanical attachment includes a metal or plastic disc adapted to be press-fit into the sensor body. In an aspect of the seventeenth embodiment, the mechanical attachment includes a metal or plastic clip adapted to be snap-fit into the sensor body.
The following description and examples illustrate some exemplary embodiments of the disclosed invention in detail. Those of skill in the art will recognize that there are numerous variations and modifications of this invention that are encompassed by its scope. Accordingly, the description of a certain exemplary embodiment should not be deemed to limit the scope of the present invention.
In order to facilitate an understanding of the disclosed invention, a number of terms are defined below.
The term “ROM,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, read-only memory. The term is inclusive of various types of ROM, including EEPROM, rewritable ROMs, flash memory, or the like.
The term “RAM,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, random access memory. The term is inclusive of various types of RAM, including dynamic-RAM, static-RAM, non-static RAM, or the like.
The term “A/D Converter,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, hardware and/or software that converts analog electrical signals into corresponding digital signals.
The term “microprocessor,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation a computer system or processor designed to perform arithmetic and logic operations using logic circuitry that responds to and processes the basic instructions that drive a computer.
The term “RF transceiver,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, a radio frequency transmitter and/or receiver for transmitting and/or receiving signals.
The terms “raw data stream” and “data stream,” as used herein, are broad terms and are used in their ordinary sense, including, without limitation, an analog or digital signal directly related to the measured glucose from the glucose sensor. In one example, the raw data stream is digital data in “counts” converted by an A/D converter from an analog signal (for example, voltage or amps) representative of a glucose concentration. The terms broadly encompass a plurality of time spaced data points from a substantially continuous glucose sensor, which comprises individual measurements taken at time intervals ranging from fractions of a second up to, for example, 1, 2, or 5 minutes or longer.
The term “counts,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, a unit of measurement of a digital signal. In one example, a raw data stream measured in counts is directly related to a voltage (for example, converted by an A/D converter), which is directly related to current from the working electrode. In another example, counter electrode voltage measured in counts is directly related to a voltage.
The term “potentiostat,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, an electrical system that controls the potential between the working and reference electrodes of a three-electrode cell at a preset value. It forces whatever current is necessary to flow between the working and counter electrodes to keep the desired potential, as long as the needed cell voltage and current do not exceed the compliance limits of the potentiostat.
The term “electrical potential,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, the electrical potential difference between two points in a circuit which is the cause of the flow of a current.
The term “physiologically feasible,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, the physiological parameters obtained from continuous studies of glucose data in humans and/or animals. For example, a maximal sustained rate of change of glucose in humans of about 4 to 5 mg/dL/min and a maximum acceleration of the rate of change of about 0.1 to 0.2 mg/dL/min/min are deemed physiologically feasible limits. Values outside of these limits would be considered non-physiological and likely a result of signal error, for example. As another example, the rate of change of glucose is lowest at the maxima and minima of the daily glucose range, which are the areas of greatest risk in patient treatment, thus a physiologically feasible rate of change can be set at the maxima and minima based on continuous studies of glucose data.
The term “ischemia,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, local and temporary deficiency of blood supply due to obstruction of circulation to a part (for example, sensor). Ischemia can be caused by mechanical obstruction (for example, arterial narrowing or disruption) of the blood supply, for example.
The term “system noise,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, unwanted electronic or diffusion-related noise which can include Gaussian, motion-related, flicker, kinetic, or other white noise, for example.
The term “biointerface membrane” as used herein is a broad term and is used in its ordinary sense, including, without limitation, a permeable membrane that functions as a device-tissue interface comprised of two or more domains. In some embodiments, the biointerface membrane is composed of two domains. The first domain supports tissue ingrowth, interferes with barrier cell layer formation, and includes an open cell configuration having cavities and a solid portion. The second domain is resistant to cellular attachment and impermeable to cells (for example, macrophages). The biointerface membrane is made of biostable materials and can be constructed in layers, uniform or non-uniform gradients (i.e., anisotropic), or in a uniform or non-uniform cavity size configuration.
The term “sensing membrane,” as used herein, is a broad term and is used in its ordinary sense, including, without limitation, a permeable or semi-permeable membrane that can be comprised of two or more domains and is typically constructed of materials of a few microns thickness or more, which are permeable to oxygen and may or may not be permeable to glucose. In one example, the sensing membrane comprises an enzyme, for example immobilized glucose oxidase enzyme, which enables an electrochemical reaction to occur to measure a concentration of analyte.
The term “domain” as used herein is a broad term and is used in its ordinary sense, including, without limitation, regions of a membrane that can be layers, uniform or non-uniform gradients (for example, anisotropic) or provided as portions of the membrane. The term is broad enough to include one or more functions one or more (combined) domains, or a plurality of layers or regions that each provide one or more of the functions of each of the various domains.
The term “barrier cell layer” as used herein is a broad term and is used in its ordinary sense, including, without limitation, a cohesive monolayer of cells (for example, macrophages and foreign body giant cells) that substantially block the transport of at least some molecules across the second domain and/or membrane.
The term “cellular attachment,” as used herein is a broad term and is used in its ordinary sense, including, without limitation, adhesion of cells and/or mechanical attachment of cell processes to a material at the molecular level, and/or attachment of cells and/or cell processes to micro- (or macro-) porous material surfaces. One example of a material used in the prior art that allows cellular attachment due to porous surfaces is the BIOPORE™ cell culture support marketed by Millipore (Bedford, Mass.) (see Brauker '"'"'330, supra).
The phrase “distal to” as used herein is a broad term and is used in its ordinary sense, including, without limitation, the spatial relationship between various elements in comparison to a particular point of reference. For example, some embodiments of a device include a biointerface membrane having a cell disruptive domain and a cell impermeable domain. If the sensor is deemed to be the point of reference and the cell disruptive domain is positioned farther from the sensor, then that domain is distal to the sensor.
The term “proximal to” as used herein is a broad term and is used in its ordinary sense, including, without limitation, the spatial relationship between various elements in comparison to a particular point of reference. For example, some embodiments of a device include a biointerface membrane having a cell disruptive domain and a cell impermeable domain. If the sensor is deemed to be the point of reference and the cell impermeable domain is positioned nearer to the sensor, then that domain is proximal to the sensor.
The term “cell processes” as used herein is a broad term and is used in its ordinary sense, including, without limitation, pseudopodia of a cell.
The term “solid portions” as used herein is a broad term and is used in its ordinary sense, including, without limitation, a solid material having a mechanical structure that demarcates the cavities, voids, or other non-solid portions.
The term “substantial” as used herein is a broad term and is used in its ordinary sense, including, without limitation, a sufficient amount that provides a desired function. For example, in the micro-architecture of the preferred embodiments, a substantial number of cavities have a size that allows a substantial number of inflammatory cells to enter therein, which may include an amount greater than 50 percent, an amount greater than 60 percent, an amount greater than 70 percent, an amount greater than 80 percent, and an amount greater than 90 percent of cavities within a preferred nominal pore size range.
The term “co-continuous” as used herein is a broad term and is used in its ordinary sense, including, without limitation, a solid portion wherein an unbroken curved line in three dimensions exists between any two points of the solid portion.
The term “biostable” as used herein is a broad term and is used in its ordinary sense, including, without limitation, materials that are relatively resistant to degradation by processes that are encountered in vivo.
The term “analyte” as used herein is a broad term and is used in its ordinary sense, including, without limitation, to refer to a substance or chemical constituent in a biological fluid (for example, blood, interstitial fluid, cerebral spinal fluid, lymph fluid or urine) that can be analyzed. Analytes can include naturally occurring substances, artificial substances, metabolites, and/or reaction products. In some embodiments, the analyte for measurement by the sensing regions, devices, and methods is glucose. However, other analytes are contemplated as well, including but not limited to acarboxyprothrombin; acylcarnitine; adenine phosphoribosyl transferase; adenosine deaminase; albumin; alpha-fetoprotein; amino acid profiles (arginine (Krebs cycle), histidine/urocanic acid, homocysteine, phenylalanine/tyrosine, tryptophan); andrenostenedione; antipyrine; arabinitol enantiomers; arginase; benzoylecgonine (cocaine); biotinidase; biopterin; c-reactive protein; carnitine; carnosinase; CD4; ceruloplasmin; chenodeoxycholic acid; chloroquine; cholesterol; cholinesterase; conjugated 1-β hydroxy-cholic acid; cortisol; creatine kinase; creatine kinase MM isoenzyme; cyclosporin A; d-penicillamine; de-ethylchloroquine; dehydroepiandrosterone sulfate; DNA (acetylator polymorphism, alcohol dehydrogenase, alpha 1-antitrypsin, cystic fibrosis, Duchenne/Becker muscular dystrophy, glucose-6-phosphate dehydrogenase, hemoglobinopathies, A, S, C, E, D-Punjab, beta-thalassemia, hepatitis B virus, HCMV, HIV-1, HTLV-1, Leber hereditary optic neuropathy, MCAD, RNA, PKU, Plasmodium vivax, sexual differentiation, 21-deoxycortisol); desbutylhalofantrine; dihydropteridine reductase; diphtheria/tetanus antitoxin; erythrocyte arginase; erythrocyte protoporphyrin; esterase D; fatty acids/acylglycines; free β-human chorionic gonadotropin; free erythrocyte porphyrin; free thyroxine (FT4); free tri-iodothyronine (FT3); fumarylacetoacetase; galactose/gal-1-phosphate; galactose-1-phosphate uridyltransferase; gentamicin; glucose-6-phosphate dehydrogenase; glutathione; glutathione perioxidase; glycocholic acid; glycosylated hemoglobin; halofantrine; hemoglobin variants; hexosaminidase A; human erythrocyte carbonic anhydrase I; 17 alpha-hydroxyprogesterone; hypoxanthine phosphoribosyl transferase; immunoreactive trypsin; lactate; lead; lipoproteins ((a), B/A-1, β); lysozyme; mefloquine; netilmicin; phenobarbitone; phenytoin; phytanic/pristanic acid; progesterone; prolactin; prolidase; purine nucleoside phosphorylase; quinine; reverse tri-iodothyronine (rT3); selenium; serum pancreatic lipase; sissomicin; somatomedin C; specific antibodies (adenovirus, anti-nuclear antibody, anti-zeta antibody, arbovirus, Aujeszky'"'"'s disease virus, dengue virus, Dracunculus medinensis, Echinococcus granulosus, Entamoeba histolytica, enterovirus, Giardia duodenalisa, Helicobacter pylori, hepatitis B virus, herpes virus, HIV-1, IgE (atopic disease), influenza virus, Leishmania donovani, leptospira, measles/mumps/rubella, Mycobacterium leprae, Mycoplasma pneumoniae, Myoglobin, Onchocerca volvulus, parainfluenza virus, Plasmodium falciparum, poliovirus, Pseudomonas aeruginosa, respiratory syncytial virus, rickettsia (scrub typhus), Schistosoma mansoni, Toxoplasma gondii, Trepenoma pallidium, Trypanosoma cruzi/rangeli, vesicular stomatis virus, Wuchereria bancrofti, yellow fever virus); specific antigens (hepatitis B virus, HIV-1); succinylacetone; sulfadoxine; theophylline; thyrotropin (TSH); thyroxine (T4); thyroxine-binding globulin; trace elements; transferrin; UDP-galactose-4-epimerase; urea; uroporphyrinogen I synthase; vitamin A; white blood cells; and zinc protoporphyrin. Salts, sugar, protein, fat, vitamins and hormones naturally occurring in blood or interstitial fluids can also constitute analytes in certain embodiments. The analyte can be naturally present in the biological fluid, for example, a metabolic product, a hormone, an antigen, an antibody, and the like. Alternatively, the analyte can be introduced into the body, for example, a contrast agent for imaging, a radioisotope, a chemical agent, a fluorocarbon-based synthetic blood, or a drug or pharmaceutical composition, including but not limited to insulin; ethanol; cannabis (marijuana, tetrahydrocannabinol, hashish); inhalants (nitrous oxide, amyl nitrite, butyl nitrite, chlorohydrocarbons, hydrocarbons); cocaine (crack cocaine); stimulants (amphetamines, methamphetamines, Ritalin, Cylert, Preludin, Didrex, PreState, Voranil, Sandrex, Plegine); depressants (barbituates, methaqualone, tranquilizers such as Valium, Librium, Miltown, Serax, Equanil, Tranxene); hallucinogens (phencyclidine, lysergic acid, mescaline, peyote, psilocybin); narcotics (heroin, codeine, morphine, opium, meperidine, Percocet, Percodan, Tussionex, Fentanyl, Darvon, Talwin, Lomotil); designer drugs (analogs of fentanyl, meperidine, amphetamines, methamphetamines, and phencyclidine, for example, Ecstasy); anabolic steroids; and nicotine. The metabolic products of drugs and pharmaceutical compositions are also contemplated analytes. Analytes such as neurochemicals and other chemicals generated within the body can also be analyzed, such as, for example, ascorbic acid, uric acid, dopamine, noradrenaline, 3-methoxytyramine (3MT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 5-hydroxytryptamine (5HT), and 5-hydroxyindoleacetic acid (FHIAA).
The terms “operably connected” and “operably linked” as used herein are broad terms and are used in their ordinary sense, including, without limitation, one or more components being linked to another component(s) in a manner that allows transmission of signals between the components. For example, one or more electrodes can be used to detect the amount of analyte in a sample and convert that information into a signal; the signal can then be transmitted to a circuit. In this case, the electrode is “operably linked” to the electronic circuitry.
The term “host” as used herein is a broad term and is used in its ordinary sense, including, without limitation, mammals, particularly humans.
The phrase “continuous (or continual) analyte sensing” as used herein is a broad term and is used in its ordinary sense, including, without limitation, the period in which monitoring of analyte concentration is continuously, continually, and or intermittently (regularly or irregularly) performed, for example, about every 5 to 10 minutes.
The term “sensing region” as used herein is a broad term and is used in its ordinary sense, including, without limitation, the region of a monitoring device responsible for the detection of a particular analyte. The sensing region generally comprises a non-conductive body, a working electrode (anode), a reference electrode and a counter electrode (cathode) passing through and secured within the body forming an electrochemically reactive surface at one location on the body and an electronic connective means at another location on the body, and a multi-region membrane affixed to the body and covering the electrochemically reactive surface. The counter electrode has a greater electrochemically reactive surface area than the working electrode. During general operation of the sensor a biological sample (for example, blood or interstitial fluid) or a portion thereof contacts (directly or after passage through one or more membranes or domains) an enzyme (for example, glucose oxidase); the reaction of the biological sample (or portion thereof) results in the formation of reaction products that allow a determination of the analyte (for example, glucose) level in the biological sample. In some embodiments, the multi-region membrane further comprises an enzyme domain (for example, and enzyme layer), and an electrolyte phase (i.e., a free-flowing liquid phase comprising an electrolyte-containing fluid described further below).
The term “electrochemically reactive surface” as used herein is a broad term and is used in its ordinary sense, including, without limitation, the surface of an electrode where an electrochemical reaction takes place. In the case of the working electrode, the hydrogen peroxide produced by the enzyme catalyzed reaction of the analyte being detected reacts creating a measurable electric current (for example, detection of glucose analyte utilizing glucose oxidase produces H2O2 peroxide as a by product, H2O2 reacts with the surface of the working electrode producing two protons (2H+), two electrons (2e−) and one molecule of oxygen (O2) which produces the electronic current being detected). In the case of the counter electrode, a reducible species, for example, O2 is reduced at the electrode surface in order to balance the current being generated by the working electrode.
The term “electronic connection” as used herein is a broad term and is used in its ordinary sense, including, without limitation, any electronic connection known to those in the art that can be utilized to interface the sensing region electrodes with the electronic circuitry of a device such as mechanical (for example, pin and socket) or soldered.
The term “oxygen antenna domain” as used herein is a broad term and is used in its ordinary sense, including, without limitation, a domain composed of a material that has higher oxygen solubility than aqueous media so that it concentrates oxygen from the biological fluid surrounding the biointerface membrane. The domain can then act as an oxygen reservoir during times of minimal oxygen need and has the capacity to provide on demand a higher oxygen gradient to facilitate oxygen transport across the membrane. This enhances function in the enzyme reaction domain and at the counter electrode surface when glucose conversion to hydrogen peroxide in the enzyme domain consumes oxygen from the surrounding domains. Thus, this ability of the oxygen antenna domain to apply a higher flux of oxygen to critical domains when needed improves overall sensor function.
The term “casting” as used herein is a broad term and is used in its ordinary sense, including, without limitation, a process where a fluid material is applied to a surface or surfaces and allowed to cure. The term is broad enough to encompass a variety of coating techniques, for example, using a draw-down machine, dip coating, or the like.
The term “water vapor permeable” as used herein is a broad term and is used in its ordinary sense, including, without limitation, characterized by permitting water vapor to permeate therethrough.
The following abbreviations apply herein: Eq and Eqs (equivalents); mEq (milliequivalents); M (molar); mM (millimolar) μM (micromolar); N (Normal); mol (moles); mmol (millimoles); μmol (micromoles); nmol (nanomoles); g (grams); mg (milligrams); μg (micrograms); Kg (kilograms); L (liters); mL (milliliters); dL (deciliters); μL (microliters); cm (centimeters); mm (millimeters); μm (micrometers); nm (nanometers); h and hr (hours); min. (minutes); s and sec. (seconds); and ° C. (degrees Centigrade).
The continuous analyte sensor 12 measures a concentration of an analyte or a substance indicative of the concentration or presence of the analyte. Although some of the following description is drawn to a glucose sensor, the analyte sensor 12 may be any sensor capable of determining the level of any analyte in the body, for example oxygen, lactase, insulin, hormones, cholesterol, medicaments, viruses, or the like. Additionally, although much of the description of the analyte sensor is focused on electrochemical detection methods, the systems and methods may be applied to analyte sensors that utilize other measurement techniques, including enzymatic, chemical, physical, spectrophotometric, polarimetric, calorimetric, radiometric, or the like.
Reference is now made to
In one preferred embodiment, the analyte sensor is a glucose sensor, wherein the sensing region 16 comprises electrode system including a platinum working electrode, a platinum counter electrode, and a silver/silver chloride reference electrode, for example. However a variety of electrode materials and configurations may be used with the implantable analyte sensor of the preferred embodiments. The top ends of the electrodes are in contact with an electrolyte phase (not shown), which is a free-flowing fluid phase disposed between a sensing membrane and the electrodes. In one embodiment, the counter electrode is provided to balance the current generated by the species being measured at the working electrode. In some embodiments, the sensing membrane includes an enzyme, for example, glucose oxidase, and covers the electrolyte phase. In the case of a glucose oxidase based glucose sensor, the species being measured at the working electrode is H2O2. Glucose oxidase catalyzes the conversion of oxygen and glucose to hydrogen peroxide and gluconate according to the following reaction:
Glucose+O2→Gluconate+H2O2
The change in H2O2 can be monitored to determine glucose concentration because for each glucose molecule metabolized, there is a proportional change in the product H2O2. Oxidation of H2O2 by the working electrode is balanced by reduction of ambient oxygen, enzyme generated H2O2, or other reducible species at the counter electrode. The H2O2 produced from the glucose oxidase reaction further reacts at the surface of working electrode and produces two protons (2H+), two electrons (2e−), and one oxygen molecule (O2).
A potentiostat (
A microprocessor module 28 includes the central control unit that houses ROM 30 and RAM 32 and controls the processing of the sensor electronics 22. It is noted that certain alternative embodiments can utilize a computer system other than a microprocessor to process data as described herein. In some alternative embodiments, an application-specific integrated circuit (ASIC) can be used for some or all the sensor'"'"'s central processing as is appreciated by one skilled in the art. The ROM 30 provides semi-permanent storage of data, for example, storing data such as sensor identifier (ID) and programming to process data streams (for example, programming for data smoothing and/or replacement of signal artifacts such as described in copending U.S. patent application Ser. No. 10/648,849 and entitled, “SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM,” filed Aug. 22, 2003, which is incorporated herein by reference in its entirety). The RAM 32 can be used for the system'"'"'s cache memory, for example for temporarily storing recent sensor data. In some alternative embodiments, memory storage components comparable to ROM 30 and RAM 32 may be used instead of or in addition to the preferred hardware, such as dynamic-RAM, static-RAM, non-static RAM, EEPROM, rewritable ROMs, flash memory, or the like.
A battery 34 is operably connected to the sensor electronics 22 and provides the necessary power for the sensor 12. In one embodiment, the battery is a Lithium Manganese Dioxide battery, however any appropriately sized and powered battery can be used (for example, AAA, Nickel-cadmium, Zinc-carbon, Alkaline, Lithium, Nickel-metal hydride, Lithium-ion, Zinc-air, Zinc-mercury oxide, Silver-zinc, and/or hermetically-sealed). In some embodiments the battery is rechargeable. In some embodiments, a plurality of batteries can be used to power the system. In yet other embodiments, the sensor can be transcutaneously powered via an inductive coupling, for example. In some embodiments, a quartz crystal 36 is operably connected to the microprocessor 28 and maintains system time for the computer system as a whole.
An RF module 38 is operably connected to the microprocessor 28 and transmits the sensor data from the sensor 12 to a receiver 14 within a wireless transmission 40 via antenna 42. In some embodiments, a second quartz crystal 44 provides the system time for synchronizing the data transmissions from the RF transceiver. The RF transceiver generally includes a register and a phase-locked loop (PLL) with an oscillator, phase discriminator (PD), loop filter (LPF), and a voltage-controlled oscillator (VCO) as is appreciated by one skilled in the art. In some alternative embodiments, however, other mechanisms such as optical, infrared radiation (IR), ultrasonic, or the like may be used to transmit and/or receive data.
It is noted that the preferred embodiments advantageously encapsulate the electronics in a water vapor permeable material, such as described in more detail with reference to
The electronics subassembly 46 generally includes hardware and software designed to support the functions described above; additionally, the electronics subassembly of the preferred embodiments is configured to accommodate certain preferred design parameters described herein, which facilitate analyte sensor immobilization within the subcutaneous pocket. Immobilization of the sensor within the host tissue is advantageous because motion (for example, acute and/or chronic movement of the sensor in the host tissue) has been found to produce acute and/or chronic inflammation, which has been shown to result in poor short-term and/or long-term sensor performance. For example, during an experiment wherein larger, bulkier versions of the analyte sensor were implanted in humans for an average of 44 days+/−14 days [See Garg, S.; Schwartz, S.; Edelman, S. “Improved Glucose Excursions Using an Implantable Real-Time Continuous Glucose Sensor in Adults with Type I Diabetes.” Diabetes Care 2004, 27, 734-738], it was discovered that movement of the sensor resulted in thicker foreign body capsule formation, which correlated with decreased sensor performance. While not wishing to be bound by theory, it is believed that size optimization (for example, miniaturization) of the analyte sensor enables more discrete and secure implantation, and is believed to reduce macro-motion of the sensor induced by the patient and micro-motion caused by movement of the sensor within the subcutaneous pocket, and thereby improve sensor performance.
Additionally, in contrast to devices made from hermetic materials, the preferred embodiments of the present invention advantageously encapsulate the electronics in a material that is water vapor permeable. The use of a water vapor permeable material, for example moldable plastic, is advantageous for a variety of reasons described elsewhere herein, for example, ease of design changes, security and alignment of the electronics during and after the molding process, and the ability to machine the device with precise curvatures. In some embodiments, the electronic subassembly possesses features that maintain the frequency of the voltage controlled oscillator (VCO) if water vapor penetrates into the water vapor permeable sensor body. For example, in some embodiments, the electronics subassembly reduces changes in the inductor parameters, which may otherwise occur as a result of water vapor within the electromagnetic field of the inductor (for example, which may result in a shift in the carrier frequency of the VCO). Such field effects may cause the VCO to transmit off of its tuned carrier frequency, which degrades the RF telemetry capabilities of the sensor. Furthermore, the carrier frequency of the sensor of the preferred embodiments is optimized for sensor longevity.
Additionally, the analyte sensor of the preferred embodiments supports a high frequency, low power operation, which supports miniaturization of the analyte sensor with optimized functionality. Accordingly, the design of the electronics subassembly 46 of the preferred embodiments provides a discrete, efficient configuration, while maintaining long-term power supply and functional RF telemetry within the water vapor permeable body in vivo.
The PCB 48 supports the components, for example microprocessor module 28, including ROM 30 and RAM 32, the potentiostat 24, A/D converter 26, RF module 38, two crystals 36, 44, and a variety of other supporting components, deposited bonding pads, and conductors, which provide the necessary functionality described above. Additionally, the electronics subassembly 46 supports an electrode system 54 including a working electrode 54a, a reference electrode 54b, and a counter electrode 54c in one embodiment, such as described in more detail above in the Overview section, however alternative electrode systems and/or measurement techniques may be implemented.
The antenna board 50, on which the antenna (42 in
Reference is now made to the electrode system 54 of the preferred embodiments, including the working electrode (anode) 54a, the reference electrode 54b, and the counter electrode (cathode) 54c, such as shown in
The working electrode 54a and counter-electrode 54c of a glucose oxidase-based glucose sensor 12 require oxygen in different capacities. Within the enzyme layer above the working electrode 54a, oxygen is required for the production of H2O2 from glucose. The H2O2 produced from the glucose oxidase reaction further reacts at the surface of the working electrode 54a and produces two electrons. The products of this reaction are two protons (2H+), two electrons (2e−), and one oxygen molecule (O2) (See Fraser, D. M. “An Introduction to In Vivo Biosensing: Progress and problems.” In “Biosensors and the Body,” D. M. Fraser, ed., 1997, pp. 1-56 John P. Wiley and Sons, New York). In theory, the oxygen concentration near the working electrode 54a, which is consumed during the glucose oxidase reaction, is replenished by the second reaction at the working electrode 54a; therefore, the net consumption of oxygen is zero. In practice, however, not all of the H2O2 produced by the enzyme diffuses to the working electrode surface nor does all of the oxygen produced at the electrode diffuse to the enzyme domain.
Additionally, the counter electrode 54c utilizes oxygen as an electron acceptor. The most likely reducible species for this system are oxygen or enzyme generated peroxide (Fraser, D. M. supra). There are two main pathways by which oxygen may be consumed at the counter electrode 54c. These are a four-electron pathway to produce hydroxide and a two-electron pathway to produce hydrogen peroxide. Oxygen is further consumed above the counter electrode by the glucose oxidase. Due to the oxygen consumption by both the enzyme and the counter electrode, there is a net consumption of oxygen at the surface of the counter electrode 54c. Thus, in the domain of the working electrode 54a there may be significantly less net loss of oxygen than in the region of the counter electrode 54c. Furthermore, it is noted that there is a close correlation between the ability of the counter electrode 54c to maintain current balance and sensor performance. Taken together, it is believed that counter electrode 54c function becomes limited before the enzyme reaction becomes limited when oxygen concentration is lowered. When this occurs, the counter electrode limitation begins to manifest itself as this electrode moves to increasingly negative voltages in the search for reducible species. Thus, when a sufficient supply of reducible species, such as oxygen, is not available to a conventional sensor, the counter electrode voltage reaches a circuitry limit, resulting in compromised sensor performance.
In order to overcome the above-described limitations, the diameter of the counter electrode is at least twice the diameter of the working electrode, resulting in an approximately 6-fold increase in the exposed surface area of the counter electrode of the preferred embodiment. Preferably, the surface area of the electrochemically reactive surface of the counter electrode is not less than about 2 times the surface area of the working electrode. More preferably, the surface area of the electrochemically reactive surface of the counter electrode is between about 2 and about 50, between about 2 and about 25, or between about 2 and about 10 times the surface area of the working electrode.
Reference is now made to
Thus, potentiostat 24 creates current in the counter electrode by controlling the voltage applied between the reference and the working electrode. The reaction that occurs on the counter electrode is determined by how much voltage is applied to the counter electrode. By increasing the voltage applied to the counter electrode, increased amount and type of species may react in order to create the necessary current, which may be advantageous for the same reasons as described above with reference to the electrode configuration of the preferred embodiments.
In addition to the net oxygen loss described above, implantable glucose sensors face an additional challenge in maintaining sensor output during ischemic conditions, which may occur either as short-term transient events (for example, compression caused by postural effects on the device) or as long-term low oxygen conditions (for example, caused by a thickened FBC or barrier cells). When the sensor is in a low oxygen environment, the potentiostat will react by decreasing the voltage relative to the reference electrode voltage applied to the counter electrode, which may result in other less electro-active species reacting at the counter electrode.
In some embodiments, the potentiostat settings are configured to allow the counter electrode to react with other reducible species when oxygen concentration is low. In some circumstances, glucose sensors may suffer from a negative voltage setting that is too low, particularly in low oxygen environments. For example, as the voltage on the counter electrode becomes more negative, it will begin to create current, by reacting with other reducible species, a byproduct of this reaction is H2. Two potential problems can occur because of the production of Hydrogen at the counter electrode: 1) bubble formation, which disconnects the counter from the current carrying buffer and causes the sensor to lose function and 2) an interfering signal at the working electrode.
In order to overcome the potential problems, the preferred embodiments optimize the potentiostat settings to enable functionality of the potentiostat even in low oxygen conditions while limiting the counter electrode to ensure that the sensor does not create conditions that could damage it. Namely, such that when oxygen concentration decreases, the counter electrode is pushed negative enough to allow it to react with the next most abundant reducible species, for example water, which is not typically limited (for example, in vivo).
In one embodiment, the potentiostat settings are optimized by setting the allowable range for the counter electrode voltage sufficiently wide such that the sensor can react with other reducible species when oxygen becomes limited, while setting the range sufficiently narrow to ensure the circuitry does not allow excessive current draw or bubble formation to occur. The counter electrode is preferably restricted such that the species that will react at the counter electrode electroactive surface do not restrict the contact of the counter electrode, while causing excess current flow and potential current damage. Thus, the negative voltage range is preferably wide enough to function in low oxygen environments, while being limited enough to prevent the sensor from applying a voltage to the counter electrode that would cause bubble formation. The limit also provides a fail-safe mechanism for prevention of a H2 feedback loop. If hydrogen diffuses to the working electrode and creates current the counter electrode would be pushed to its electronic limit. When the potentiostat reaches the electronic limit it is no longer able to maintain the potential applied between the working and the reference electrode and the applied potential is decreased. At this point, a maximum limiting electrode current condition is attained. Additionally, the optimized potentiostat settings of the preferred embodiments provide a failsafe mechanism that prevents a cascade reaction that could cause damage to the sensor.
In one implementation of an implantable glucose sensor, a reference voltage between about +0.6V and +0.8V, and preferably about +0.7V, with respect to battery ground is chosen to ensure functionality even in low oxygen conditions yet limiting the counter electrode to a minimum of potential equal to ground potential to ensure that the sensor does not create conditions that could damage it. However, one skilled in the art appreciates that the ratio of the electroactive surface areas of the working and counter electrodes will influence the voltage operating point of the counter electrode with larger counter electrode areas requiring a less negative voltage relative to the reference electrode voltage for the same working electrode current. Additionally, one skilled in the art appreciates that optimization of the potentiostat to produce the above-described results can be attained by limitations other than on the reference voltage, for example, by limiting the current of the working or counter electrode amplifiers to a preset current limit or by setting or the op-amp offset (VOFFSET) from battery ground (see
Reference is now made to
Therefore, the preferred embodiments provide for a mechanical and electrical connection of the electrodes 54 to the PCB 48 that is extremely secure, robust, and easily reproducible in manufacture. In preferred embodiments, the electrodes 54 are swaged to the PCB 48 prior to assembling the electronics subassembly. Referring to
Swaging is a process whereby metal is shaped by hammering or pressure with the aid of a form or anvil called a swage block, substantially without heating. Notably, swaging is a solderless attachment with good mechanical accuracy, stability, orientation, and provides a quick and clean method of manufacture. The resulting swaged electrode-to-PCB connection 60 at least in part enables the reliable encapsulation of the electronics subassembly in a molded material and longevity of the device due to reliability and reproducibility of a stable electrode system 54.
In some alternative embodiments the electrodes 54 are welded to the PCB 48, which may include, for example, spot welding, laser welding, ultrasonic welding, or the like. Although these techniques include some heating, they are typically cleaner than conventional soldering techniques, for example, and may be advantageous in the some embodiments.
In an alternative embodiment, the inductor 62 may be shielded from water vapor by a metal dome, box, or cover 68, for example, such as shown in
Referring now to the configuration of the RF telemetry module of the preferred embodiments, the hardware and software are designed for low power requirements to increase the longevity of the device (for example, to enable a life of 3 to 24 months) with maximum RF transmittance from the in vivo environment to the ex vivo environment (for example, about one to ten meters). Preferably, a high frequency carrier signal in the range of 402 to 405 MHz is employed in order to maintain lower power requirements. Additionally, the carrier frequency is adapted for physiological attenuation levels, which is accomplished by tuning the RF module in a simulated in vivo environment to ensure RF functionality after implantation. Accordingly, it is believed that the preferred glucose sensor can sustain sensor function for greater than 3 months, greater than 6 months, greater than 12 months, and greater than 24 months.
In some alternative embodiments, hermetic packaging encompasses some parts of the implantable analyte sensor, while water vapor permeable packaging encompasses other parts of the implantable analyte sensor. For example, the implantable analyte sensor body may be formed from a hermetic material (such as Titanium), which encompasses the RF circuitry and/or other water vapor-sensitive components; and a water vapor permeable insert or piece may be incorporated onto the hermetic body, which encompasses the antenna and/or other non-water vapor-sensitive components operably connected thereto. In this way, the RF circuitry and other sensitive components are protected from negative effects that water vapor causes, while allowing unobstructed transmissions and receiving via the antenna.
In the preferred embodiments, a substantial portion of the electronics 46 is coated with a conformal coating 66. This conformal coating preferably has a water permeability rate that is less than the water permeability rate of the sensor body and enables sufficient spacing for the electromagnetic field as described in more detail above with reference to
In one preferred embodiment, one or more conformal Parylene coatings are applied prior to encapsulation in the sensor body. Parylene is known to have a slow water vapor permeability rate and is suitable for biomedical applications. The Parylene coating process exposes product to the gas-phase monomer at low pressure. Through vacuum deposition, Parylene condenses on the object'"'"'s surface in a polycrystalline fashion, providing a coating that is truly conformal and pinhole free. Compared to liquid processes, the effects of gravity and surface tension are negligible so there is no bridging, thin-out, pinholes, puddling, run-off or sagging; additionally, the process takes place at room temperature so there is no thermal or mechanical stress on the product. Parylene is physically stable and chemically inert within its usable temperature range. Parylene provides excellent protection from water vapor, corrosive vapors, and solvents, for example. In alternative embodiments, other conformal coatings (for example, HumiSeal®, Woodside, N.Y.), spray coatings, or the like, may be used for the less- or minimally-water vapor penetrable layer, which protect the PCB 48 and electronics subassembly 46 from damage during the molding process (
In one alternative embodiment, a coating of a secondary material, such as silicone, is applied after the protective coating 66. The secondary coating is preferably made from a material that is able to absorb mechanical stresses that may be translated from the molding process to the sensitive electrical components beneath the protective coating. Thus, silicone, or other similar material with sufficient elasticity or ductility, may be applied to the coated electronics subassembly prior to forming the sensor body, which is described in more detail below.
In one embodiment, the body of the sensor is preferably formed from a plastic material molded around the sensor electronics, however in alternative embodiments, the body may be formed from a variety of materials, including metals, ceramics, plastics, resins, or composites thereof.
It is noted that conventional prior art implantable sensors that have electronics therein generally use a hermetic material for at least a portion of the body that houses the sensitive electronics. However conventional hermetic implantable devices suffer from numerous disadvantages including: difficulty in RF transmissions through the hermetic material, seams that may allow water vapor penetration if not perfectly sealed, minimal design or shape changes without major manufacturing changes (inability to rapidly iterate on design), and need to mechanically hold and reinforce the electronics inside, increased weight and density, for example.
To overcome the disadvantages of the prior art, the preferred embodiments mold a plastic material around the electronics subassembly 46 (
Referring now to the molding process for forming the body, a two-step process is preferably used in order to provide a total seal of the components within the device and for forming a seamless device with a desired curvature thereon. The two-step molding process decreases micro-fissures that may form during the initial molding step, while mechanically securing and protecting the electrical components. However, some alternative embodiments may utilize a one-step molding process, for example by injection-molding the device.
During the primary casting process, the primary mold 70 is preferably pre-filled with a predetermined amount of a selected plastic material in order to substantially cover the lower portion 72 of the primary mold 70. The electronics subassembly 46 is then pressed into the pre-filled primary mold 70, after which the material 74 is filled around the electronics subassembly 46 to a predetermined fill line or weight amount, ensuring minimal or no air bubbles exist within the material (
During the secondary casting process, the secondary mold 80 is pre-filled with a predetermined amount of the selected material in order to substantially cover the lower portion of the secondary mold 80. The primary potted device 78 is then pressed into the pre-filled secondary mold 80, after which the material 74 is filled around the primary potted device to a predetermined fill line or weight amount, ensuring minimal or no air bubbles exist within the material. Finally a secondary hold down fixture is secured over the device. The material is cured using standard techniques known in the art, for example the plastic material may be placed into a pressure vessel and heated, or the like. It is noted that this secondary casting is advantageous because it creates additional strength over a primary casting alone, fills in micro-fissures or other damage that may have occurred during or after the primary process, and provides a seamless exterior to prevent leakage into the device.
Reference is now made to
It is noted that additional outer coatings may be advantageously applied to the secondary potted device 82, such as one or more Parylene coatings, in order to decrease water vapor penetration, for example. As another example of an outer coating, a silicone layer may be applied to the non-sensing region of the device, which serves to fill in any microfissures or micropores, for example, within the molded material, to provide a smooth outer surface, and/or to enable attachment of additional materials (for example, a silicone anchoring material). Other coatings may be applied as is appreciated by one skilled in the art.
In some alternative embodiments, the electronics subassembly 46 is placed within a pre-formed shell, rather than molding the body around the subassembly. In these alternative embodiments, the shell configuration advantageously provides air space surrounding the electronics, which aids in maintaining a stable dielectric constant surrounding the VCO circuitry, such as described in more detail with reference to
In this illustration, the analyte sensor 12 is shown without subsequent membrane and anchoring material thereon and is used to illustrate sensor geometry. The analyte sensor 12 includes the sensing region 16 located on a curved portion of the sensor body, and including no abrupt edge or discontinuous surface in the proximity of the sensing region. Additionally, the overall curvature of the surface on which the sensing region is located, including rounded edges, invokes a generally uniform FBC around that surface, decreasing inflammatory response and increasing analyte transport at the device-tissue interface.
Perpendicular forces 84, depicted in
In preferred embodiments, the sensing membrane is constructed of two or more domains and is disposed adjacent to the electroactive surfaces of the sensing region 16. The sensing membrane provides functional domains that enable measurement of the analyte at the electroactive surfaces. For example, the sensing membrane includes an enzyme, which catalyzes the reaction of the analyte being measured with a co-reactant (for example, glucose and oxygen) in order to produce a species that in turn generates a current value at the working electrode, such as described in more detail above in the Overview section. The sensing membrane can be formed from one or more distinct layers and can comprise the same or different materials.
In some embodiments, the sensing membrane 88 includes an enzyme, for example, glucose oxidase, and covers the electrolyte phase. In one embodiment, the sensing membrane 88 generally includes a resistance domain 90 most distal from the electrochemically reactive surfaces, an enzyme domain 92 less distal from the electrochemically reactive surfaces than the resistance domain, and an electrolyte domain 96 adjacent to the electrochemically reactive surfaces. However, it is understood that a sensing membrane modified for other devices, for example, by including fewer or additional domains, is within the scope of the preferred embodiments. Co-pending U.S. patent application Ser. No. 09/916,711, entitled, “SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES” and U.S. patent application Ser. No. 10/153,356 entitled, “TECHNIQUES TO IMPROVE POLYURETHANE MEMBRANES FOR IMPLANTABLE GLUCOSE SENSORS,” which are incorporated herein by reference in their entirety, describe membranes that can be used in the preferred embodiments. It is noted that in some embodiments, the sensing membrane 88 may additionally include an interference domain 94 that limits some interfering species; such as described in the above-cited co-pending patent application. Co-pending U.S. patent application Ser. No. 10/695,636, entitled, “SILICONE COMPOSITION FOR BIOCOMPATIBLE MEMBRANE” also describes membranes that may be used for the sensing membrane of the preferred embodiments, and is incorporated herein by reference in its entirety.
In some embodiments, the domains of the sensing membrane are formed from materials such as silicone, polytetrafluoroethylene, polyethylene-co-tetrafluoroethylene, polyolefin, polyester, polycarbonate, biostable polytetrafluoroethylene, homopolymers, copolymers, terpolymers of polyurethanes, polypropylene (PP), polyvinylchloride (PVC), polyvinylidene difluoride (PVDF), polybutylene terephthalate (PBT), polymethylmethacrylate (PMMA), polyether ether ketone (PEEK), polyurethanes, cellulosic polymers, polysulfones and block copolymers thereof including, for example, di-block, tri-block, alternating, random and graft copolymers, or the like.
Referring now to the function of the resistance domain 90, it is noted that there exists a molar excess of glucose relative to the amount of oxygen in blood; that is, for every free oxygen molecule in extracellular fluid, there are typically more than 100 glucose molecules present (see Updike et al., Diabetes Care 5:207-21 (1982)). However, an immobilized enzyme-based sensor employing oxygen as cofactor should be supplied with oxygen in non-rate-limiting excess in order to respond linearly to changes in glucose concentration, while not responding to changes in oxygen tension. More specifically, when a glucose-monitoring reaction is oxygen-limited, linearity is not achieved above minimal concentrations of glucose. Without a semipermeable membrane situated over the enzyme domain to control the flux of glucose and oxygen, a linear response to glucose levels can be obtained only up to about 40 mg/dL. However, in a clinical setting, a linear response to glucose levels is desirable up to at least about 500 mg/dL.
The resistance domain 90 includes a semipermeable membrane that controls the flux of oxygen and glucose to the underlying