Devices and systems that deliver nitric oxide

• US 20090112295A1
• Filed: 12/21/2007
• Published: 04/30/2009
• Est. Priority Date: 10/30/2007
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Stordal, Leif T., Ishikawa, Muriel Y., Wood, Lowell L. JR., Hyde, Roderick A.
• Granted Patent: US 7,862,598 B2
• Time in Patent Office: Days
• US Class Current: 607/88
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/445 Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61F 2013/00646 Medication patches, e.g. transcutaneous
• CPC Class Codes: A61F 2013/00906 for transcutaneous or transdermal drugs application
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

The present disclosure relates to dressings, such as patches and bandages, and other devices and systems that deliver nitric oxide.

Claims

1. A dressing comprising:

one or more backing sheets; and

one or more photolyzable nitric oxide donors associated with the one or more backing sheets.

2. The dressing of claim 1, wherein the one or more backing sheets comprise:

one or more adhesive portions.

6. The dressing of claim 1, wherein the one or more backing sheets comprise:

one or more gas impermeable backing sheets.

8. The dressing of claim 1, wherein the one or more backing sheets comprise:

one or more light impermeable backing sheets.

11. The dressing of claim 1, wherein the one or more backing sheets comprise:

one or more metallic backing sheets.

19. The dressing of claim 1, wherein the one or more backing sheets comprise:

one or more transparent backing sheets.

20. The dressing of claim 1, wherein the one or more backing sheets comprise:

one or more backing sheets that are configured as a bandage, a medical tape, a medical dressing, a surgical dressing, a surgical drape, or athletic tape.

21. The dressing of claim 1, wherein the one or more backing sheets comprise:

one or more backing sheets that are configured as a sock, a glove, a condom, a body wrap, or a hood.

22. The dressing of claim 1, wherein the one or more photolyzable nitric oxide donors associated with the one or more backing sheets comprise:

one or more photolyzable nitric oxide donors that include one or more diazeniumdiolates.

23. The dressing of claim 1, wherein the one or more photolyzable nitric oxide donors associated with the one or more backing sheets comprise:

one or more photolyzable nitric oxide donors that are associated with one or more quantum dots.

25. The dressing of claim 1, wherein the one or more photolyzable nitric oxide donors associated with the one or more backing sheets comprise:

one or more photolyzable nitric oxide donors that are associated with one or more rare-earth materials that facilitate upconversion of energy.

27. The dressing of claim 1, further comprising:

one or more nitric oxide permeable layers.

29. The dressing of claim 27, wherein the one or more nitric oxide permeable layers comprise:

one or more nitric oxide permeable layers that include one or more nitric oxide selective membranes.

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31. A dressing comprising:

one or more backing sheets;

one or more light sources operably associated with the one or more backing sheets; and

one or more photolyzable nitric oxide donors operably associated with the one or more light sources.

32. The dressing of claim 31, wherein the one or more backing sheets comprise:

one or more adhesive portions.

36. The dressing of claim 31, wherein the one or more backing sheets comprise:

one or more gas impermeable backing sheets.

38. The dressing of claim 31, wherein the one or more backing sheets comprise:

one or more light impermeable backing sheets.

41. The dressing of claim 31, wherein the one or more backing sheets comprise:

one or more metallic backing sheets.

49. The dressing of claim 31, wherein the one or more backing sheets comprise:

one or more transparent backing sheets.

50. The dressing of claim 31, wherein the one or more backing sheets comprise:

one or more backing sheets that are configured as a bandage, a medical tape, a medical dressing, a surgical dressing, a surgical drape, or athletic tape.

51. The dressing of claim 31, wherein the one or more backing sheets comprise:

one or more backing sheets that are configured as a sock, a glove, a condom, a body wrap, or a hood.

54. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more electromagnetic receivers.

55. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more control units.

58. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more light sources that are associated with the one or more photolyzable nitric oxide donors through one or more optical waveguides.

59. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more light sources that include one or more quantum dots.

61. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more light sources that are associated with one or more rare-earth materials.

66. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more light sources that emit infrared light.

67. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more light sources that are configured to emit light that specifically facilitates release of nitric oxide from the one or more photolyzable nitric oxide donors.

68. The dressing of claim 31, wherein the one or more light sources operably associated with the one or more backing sheets comprise:

one or more light sources that are configured to emit light that specifically selected to avoid damaging one or more tissues.

70. The dressing of claim 31, wherein the one or more photolyzable nitric oxide donors operably associated with the one or more light sources comprise:

one or more photolyzable nitric oxide donors that include one or more diazeniumdiolates.

71. The dressing of claim 31, wherein the one or more photolyzable nitric oxide donors operably associated with the one or more light sources comprise:

one or more photolyzable nitric oxide donors that are associated with one or more quantum dots.

73. The dressing of claim 31, wherein the one or more photolyzable nitric oxide donors operably associated with the one or more light sources comprise:

one or more photolyzable nitric oxide donors that are associated with one or more rare-earth materials that facilitate upconversion of energy.

75. The dressing of claim 31, further comprising:

one or more nitric oxide permeable layers.

77. The dressing of claim 75, wherein the one or more nitric oxide permeable layers comprise:

one or more nitric oxide permeable layers that include one or more nitric oxide selective membranes.

79. The dressing of claim 31, further comprising:

one or more control units.

82. The dressing of claim 79, wherein the one or more control units comprise:

one or more receivers that are configured to receive one or more signals.

83. The dressing of claim 79, wherein the one or more control units comprise:

one or more receivers that are configured to receive one or more signals from one or more sensors.

84. The dressing of claim 79, wherein the one or more control units comprise:

one or more transmitters.

85. The dressing of claim 79, wherein the one or more control units comprise:

one or more control units that regulate the one or more light sources.

92. The dressing of claim 79, wherein the one or more control units comprise:

one or more control units that regulate in response to one or more programs.

93. The dressing of claim 79, wherein the one or more control units comprise:

one or more control units that regulate in response to one or more commands.

95. The dressing of claim 79, wherein the one or more control units comprise:

one or more control units that include memory.

98. The dressing of claim 79, further comprising:

one or more nitric oxide permeable layers.

101. The dressing of claim 98, wherein the one or more nitric oxide permeable layers comprise:

one or more nitric oxide permeable layers that include one or more nitric oxide selective membranes.

103. The dressing of claim 79, further comprising:

one or more sensors.

107. The dressing of claim 103, wherein the one or more sensors comprise:

one or more sensors that are configured to detect one or more microbes.

108. The dressing of claim 103, wherein the one or more sensors comprise:

one or more sensors that are configured to detect nitric oxide.

110. The dressing of claim 103, wherein the one or more sensors comprise:

one or more sensors that are configured to detect one or more nitric oxide donors.

111. The dressing of claim 103, wherein the one or more sensors comprise:

one or more sensors that are operably coupled to the one or more control units.

113. The dressing of claim 103, wherein the one or more sensors comprise:

one or more sensors that are configured to transmit one or more signals.

120. The dressing of claim 103, further comprising:

one or more nitric oxide permeable layers.

122. The dressing of claim 120, wherein the one or more nitric oxide permeable layers comprise:

one or more nitric oxide permeable layers that include one or more nitric oxide selective membranes.

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187. A dressing comprising:

one or more backing sheets;

one or more photolyzable nitric oxide donors;

one or more rare-earth materials;

one or more light sources that are configured to emit light that is upconverted by the one or more rare earth materials to facilitate release of nitric oxide from the one or more photolyzable nitric oxide donors; and

one or more nitric oxide permeable layers.