SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

• US 20090124878A1
• Filed: 01/14/2009
• Published: 05/14/2009
• Est. Priority Date: 08/22/2003
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brauker, James H., Carr-Brendel, Victoria, Thrower, James Patrick, Kamath, Apurv U., Goode, Paul V. JR.
• Granted Patent: US 7,935,057 B2
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/0271 Thermal or temperature sensors
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick

Abstract

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

Claims

1. A system for processing data signals obtained from a glucose sensor, the system comprising:

a receiving module that receives a signal from a glucose sensor over a period of time; and

a processor module comprising programming that detects transient non-glucose related signal artifacts and replaces at least some of the signal artifacts with estimated glucose values.

2. The system of claim 1, further comprising a glucose sensor.

3. The system of claim 1, wherein the programming configured to replace at least some of the signal artifacts is configured to output the estimated glucose values in response to detection of transient non-glucose related signal artifacts, wherein the estimated glucose values comprise filtered, calibrated glucose values.

4. The system of claim 3, wherein the processor module further comprises programming configured to output unfiltered, calibrated glucose values when transient non-glucose related signal artifacts are not detected.

5. A system for processing data signals obtained from a glucose sensor, the system comprising:

a receiving module that receives a signal from a glucose sensor over a period of time; and

a processor module comprising programming that detects transient non-glucose related signal artifacts and outputs estimated glucose values during transient non-glucose related signal artifacts.

6. The system of claim 5, further comprising a glucose sensor.

7. The system of claim 5, wherein the programming configured to output estimated glucose values during transient non-glucose related signal artifacts is configured to display data representative of the estimated glucose values, including at least one of a numeric representation of the estimated glucose values, an indication of directional trend of the estimated glucose values, and a graphical representation of the estimated glucose values in response to detection of transient non-glucose related signal artifacts, wherein the estimated glucose values comprise filtered, calibrated glucose values.

8. The system of claim 7, wherein the processor module further comprises programming configured to output unfiltered, calibrated glucose values when transient non-glucose related signal artifacts are not detected.

9. A system for processing data signals obtained from a glucose sensor, the system comprising:

a receiving module that receives a signal from a glucose sensor over a period of time; and

a processor module comprising programming that detects transient non-glucose related signal artifacts and selectively displays unfiltered glucose values when signal artifacts are not detected and filtered glucose values when signal artifacts are detected.

10. The system of claim 9, further comprising a glucose sensor.

11. The system of claim 9, wherein the unfiltered glucose values are calibrated unfiltered glucose values.

12. The system of claim 9, wherein the filtered glucose values are calibrated filtered glucose values.

13. The system of claim 9, wherein the programming that displays is configured to display at least one of a numeric representation of the glucose values, an indication of directional trend of the glucose values, and a graphical representation of the glucose values.