Articles having ceramic coated surfaces

• US 20090138077A1
• Filed: 07/27/2007
• Published: 05/28/2009
• Est. Priority Date: 07/27/2007
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Weber, Jan, Zoromski, Michele
• Granted Patent: US 7,931,683 B2
• Time in Patent Office: Days
• US Class Current: 623/1.460
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: C23C 18/1208 Oxides, e.g. ceramics
• CPC Class Codes: C23C 18/1254 Sol or sol-gel processing
• CPC Class Codes: C23C 18/127 Preformed particles
• CPC Class Codes: C23C 26/00 Coating not provided for in groups C23C2/00 - C23C24/00
• CPC Class Codes: Y10T 428/24926 including ceramic, glass, porcelain or quartz layer
• CPC Class Codes: Y10T 428/2918 including free carbon or carbide or therewith [not as steel]

Abstract

According to an aspect of the invention, articles are provided which comprise a substrate and a ceramic coating which covers at least a portion of the substrate surface. The ceramic coating includes raised ceramic shells connected by a ceramic layer that is conformal with the substrate. According to another aspect of the present invention, carbon nanotubes are provided, which comprise a ceramic coating covering at least a portion of the carbon nanotubes.

Claims

1. A coated article comprising a substrate and a ceramic coating that covers at least a portion of the substrate surface, said ceramic coating comprising raised first ceramic shells connected by an underlying ceramic layer that is conformal with the substrate surface.

2. The coated article of claim 1, wherein said article is a medical article.

3. The coated article of claim 2, wherein said medical article is an implantable or insertable medical device.

4. The coated article of claim 3, wherein said medical device is selected from a stent, an electrical lead, an electrical coil, a catheter, an injection needle, a guidewire, and an embolic device.

5. The coated article of claim 1, wherein said substrate is selected from a metallic substrate and a polymeric substrate.

6. The coated article of claim 1, wherein said ceramic coating contains one or more oxides selected from oxides of silicon, titanium, zirconium, iridium, and combinations thereof.

7. The coated article of claim 1, wherein said ceramic coating contains one or more species selected from carbides and nitrides of silicon, titanium, zirconium, iridium, and combinations thereof.

8. The coated article of claim 1, wherein said first ceramic shells and said underlying ceramic layer comprise at least 90 wt % metal oxide.

9. The coated article of claim 1 wherein said first ceramic shells are at least partially hollow.

10. The coated article of claim 9, wherein said at least partially hollow first ceramic shells contain paramagnetic particles.

11. The coated article of claim 1, wherein said wherein said first ceramic shells enclose a material selected from polymeric materials, metallic materials, ceramic materials and carbon.

12. The coated article of claim 1, wherein said first ceramic shells are spherical.

13. The coated article of claim 1, wherein said first ceramic shells are elongated.

14. The coated article of claim 13, wherein said elongated shells are aligned.

15. The coated article of claim 1, further comprising second ceramic shells connected to said first ceramic shells.

16. The coated article of claim 15, further comprising a polymeric coating.

17. The coated article of claim 15, wherein said first and second ceramic shells are spherical

18. The coated article of claim 15, wherein said first and second ceramic shells are elongated.

20. The coated article of claim 1, further comprising a polymeric coating.

21. The coated article of claim 20, wherein said polymeric coating comprises a therapeutic agent.

22. The coated article of claim 21, wherein said wherein said medical device is a stent, wherein said therapeutic agent is an antiproliferative agent, wherein said ceramic coating is disposed over the entire stent, and wherein the polymeric coating is disposed over the abluminal surface of the stent and not over the luminal surface of the stent.

23. The coated article of claim 20, wherein said polymeric coating is selected from a lubricious coating, an electrically insulating coating, a bioresorbable coating and a protein coating.

24. The coated article of claim 20, wherein said first ceramic shells are spherical, and wherein the polymeric coating thickness is dictated by the height of the first ceramic shells

25. The coated article of claim 1, wherein said substrate comprises blind holes, through holes or both, and wherein said ceramic shells are preferentially positioned in the holes.

26. The coated article of claim 1, wherein said ceramic coating comprises a metal or semi-metal oxide and a polyelectrolyte.

27. The coated article of claim 26, wherein said ceramic coating further comprises a therapeutic agent.

28. The coated article of claim 1, wherein said ceramic shells enclose a material comprising a therapeutic agent.

19. The coated article of claim wherein said first ceramic shells are spherical and said second ceramic shells are elongated.

29. A carbon nanotube comprising a ceramic coating.

30. A medical article comprising carbon nanotubes with ceramic coatings.