COMPOSITIONS AND METHODS FOR TREATING PULP INFLAMMATIONS CAUSED BY INFECTION OR TRAUMA
First Claim
1. A composition comprising:
- (a) a matrix comprising;
(i) type I collagen, (ii) type III collagen, (iii) alginate, (iv) chitosan, (v) PEG-fibrinogen, or any combination thereof, and(b) pulpal cells.
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Abstract
The present disclosed subject matter relates to methods and compositions for restoring a diseased or damaged tooth such that infection is inhibited or eliminated and pulp regeneration is facilitated. The disclosed subject matter also includes a composition comprising a physiologically acceptable matrix seeded with pulp cells. The matrix can be capable of being injected into the pulp chamber of a tooth. In some embodiments, the matrix of a composition includes a hydrogel (e.g., collagen, chitosan, alginate, MATRIGEL™, gelatin, JELL-O®, fibrin), a mesh (e.g., polylactide-coglycolide (PLGA) mesh, polylactide (PLA) mesh, or polyglycolide (PGA) mesh, a cross-linked fiber mesh, a nanofiber mesh, a mesh fabric, biodegradable polymer mesh), a microsphere (biodegradable polymer microsphere, a hydrogel microsphere), or a combination of any of the foregoing. In yet other embodiments, the matrix includes a nanofiber, an artificial three-dimensional scaffold material, or a synthetic three-dimensional scaffold material.
68 Citations
44 Claims
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1. A composition comprising:
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(a) a matrix comprising;
(i) type I collagen, (ii) type III collagen, (iii) alginate, (iv) chitosan, (v) PEG-fibrinogen, or any combination thereof, and(b) pulpal cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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23. A composition comprising:
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(a) a scaffold of (i) an electrospun collagen mesh, (ii) an electrospun chitosan mesh, (iii) an electrospun alginate mesh, (iv) an extruded collagen mesh, (v) and extruded chitosan mesh, (vi) an extruded alginate mesh, (vii) a poly(lactide-co-glycolide) mesh, (viii) gelatin, or (iv) any combination thereof, and (b) at least one antibiotic, anti-fungal agent, growth factor or angiogenic factor. - View Dependent Claims (25, 26, 27, 28, 29, 39)
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24. A composition comprising:
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(a) a scaffold of (i) a nanofiber, (ii) an extracellular matrix, (iii) a degradable polymer, (iv) a mesh of crosslinked fibers, (v) an artificial or synthetic scaffold material, (vi) a polycaprolactone polymer, (vii) a poly-α
-hydroxyester polymer, (viii) a polyanhydride polymer, (ix) a polygalactin, (x) a polycyanoacrylate, (xi) a polyphosphazene, (xii) a mesh fabric, or (xiii) any combination thereof, and(b) at least one antibiotic, antifungal agent, growth factor or angiogenic factor.
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40. A method for determining whether a matrix can affect the growth and differentiation of pulpal cells, wherein the method comprises:
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(a) growing pulpal cells in the biodegradable gel matrix, (b) measuring a biological indicator, and (c) determining whether there is an increase or decrease in the biological indicator compared to a same biological indicator measured in pulpal cells not grown in a biological gel matrix, wherein an increase or a decrease in the biological indicator indicates that the matrix affects the growth or differentiation of pulpal cells. - View Dependent Claims (41, 42)
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43. A method for determining whether culturing of pulpal cells on a biodegradable gel matrix affects properties of the matrix, wherein the method comprises:
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(a) growing pulpal cells in the biodegradable gel matrix, (b) measuring a parameter of the biodegradable gel matrix, and (c) determining whether there is an increase or decrease in the parameter compared to the same parameter measured in a biodegradable matrix in which pulpal cells are not grown, wherein an increase or a decrease in the parameter indicates that culturing of pulpal cells on a biodegradable gel matrix affects properties of the matrix. - View Dependent Claims (44)
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Specification