Companion animal compositions including lipoic acid and methods of use thereof

• US 20090182032A1
• Filed: 12/30/2008
• Published: 07/16/2009
• Est. Priority Date: 10/31/2000
• Status: Active Grant

• Current Assignee: Hill's Pet Nutrition Incorporated (Colgate-Palmolive Company)
• Original Assignee: Hill's Pet Nutrition Incorporated (Colgate-Palmolive Company)
• Inventors: Frantz, Nolan Zebulon, Zicker, Steven C.
• Granted Patent: US 8,669,282 B2
• Time in Patent Office: Days
• US Class Current: 514/440
• CPC Class Codes: A23K 20/105 Aliphatic or alicyclic compounds
• CPC Class Codes: A23K 20/121 containing oxygen or sulfur as hetero atom
• CPC Class Codes: A23K 20/142 Amino acids; Derivatives thereof
• CPC Class Codes: A23K 20/158 Fatty acids; Fats; Products containing oils or fats
• CPC Class Codes: A23K 20/174 Vitamins
• CPC Class Codes: A23K 50/40 for carnivorous animals, e.g. cats or dogs
• CPC Class Codes: A23L 27/88 Taste or flavour enhancing agents
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

The invention encompasses compositions and methods for treating or preventing disorders in companion animals, wherein the compositions and methods include feeding the companion animal a composition including lipoic acid or a salt thereof.

Claims

1. A pet food composition comprising an effective amount of lipoic acid to prevent or treat a degenerative joint condition in a companion animal in need thereof, wherein said effective amount of lipoic acid to prevent or treat a degenerative joint condition is at least 25 ppm.

2. The composition of claim 1, wherein the amount is at least about 50 ppm.

3. The composition of claim 1, wherein the amount is at least about 100 ppm.

4. The composition of claim 1, wherein the amount is about 100 ppm to about 600 ppm.

5. The composition of claim 1, wherein the amount is about 100 ppm to about 200 ppm.

6. The composition of claim 1, wherein the companion animal is a dog.

7. The composition of claim 1, wherein the companion animal is a cat.

8. The composition of claim 1, wherein the degenerative joint condition comprises osteoarthritis.

9. The composition of claim 1, wherein the degenerative joint condition comprises cartilage damage.

10. A pet food composition comprising an effective amount of lipoic acid to modulate enzymatic degradation of articular cartilage in a companion animal in need thereof, wherein said effective amount of lipoic acid to modulate enzymatic degradation of articular cartilage is at least 25 ppm.

11. The composition of claim 10, wherein the amount is at least about 50 ppm.

12. The composition of claim 10, wherein the amount is at least about 100 ppm.

13. The composition of claim 10, wherein the amount is about 100 ppm to about 600 ppm.

14. The composition of claim 10, wherein the amount is about 100 ppm to about 200 ppm.

15. The composition of claim 10, wherein the companion animal is a dog.

16. The composition of claim 10, wherein the companion animal is a cat.

17. A pet food composition comprising an effective amount of lipoic acid to maintain or increase bone mineral density in a companion animal, wherein said effective amount of lipoic acid to maintain or increase bone mineral density is at least 25 ppm.

18. The composition of claim 17, wherein the amount is at least about 50 ppm.

19. The composition of claim 17, wherein the amount is at least about 100 ppm.

20. The composition of claim 17, wherein the amount is about 100 ppm to about 600 ppm.

21. The composition of claim 17, wherein the amount is about 100 ppm to about 200 ppm.

22. The composition of claim 17, wherein the companion animal is a dog.

23. The composition of claim 17, wherein the companion animal is a cat.

24. A pet food composition comprising an effective amount of lipoic acid to prevent or treat kidney-related disorders in a companion animal, wherein said effective amount of lipoic acid to prevent or treat kidney-related disorders is at least 25 ppm.

25. The composition of claim 24, wherein the amount is at least about 50 ppm.

26. The composition of claim 24, wherein the amount is at least about 100 ppm.

27. The composition of claim 24, wherein the amount is about 100 ppm to about 600 ppm.

28. The composition of claim 24, wherein the amount is about 100 ppm to about 200 ppm.

29. The composition of claim 24, wherein the companion animal is a dog.

30. The composition of claim 24, wherein the companion animal is a cat.

31. A pet food composition comprising an effective amount of lipoic acid to enhance palatability to a companion animal, wherein said effective amount of lipoic acid to enhance palatability is at least 25 ppm.

32. The composition of claim 31, wherein the amount is at least about 50 ppm.

33. The composition of claim 31, wherein the amount is at least about 100 ppm.

34. The composition of claim 31, wherein the amount is about 100 ppm to about 600 ppm.

35. The composition of claim 31, wherein the amount is about 100 ppm to about 200 ppm.

36. The composition of claim 31, wherein the companion animal is a dog.

37. The composition of claim 31, wherein the companion animal is a cat.

38. A pet food composition comprising an effective amount of lipoic acid to maintain or promote a healthy body composition in a companion animal, wherein said effective amount of lipoic acid to maintain or promote a healthy body composition in a companion animal is at least about 25 ppm.

39. The composition of claim 38, wherein the amount is at least about 50 ppm.

40. The composition of claim 38, wherein the amount is at least about 100 ppm.

41. The composition of claim 38, wherein the amount is about 100 ppm to about 600 ppm.

42. The composition of claim 38, wherein the amount is about 100 ppm to about 200 ppm.

43. The composition of claim 38, wherein the companion animal is a dog.

44. The composition of claim 38, wherein the companion animal is a cat.

45. A pet food composition comprising an effective amount of lipoic acid to induce weight loss in a companion animal, wherein said effective amount of lipoic acid to induce weight loss in a companion animal is at least about 25 ppm.

46. The composition of claim 45, wherein the amount is at least about 50 ppm.

47. The composition of claim 45, wherein the amount is at least about 100 ppm.

48. The composition of claim 45, wherein the amount is about 100 ppm to about 600 ppm.

49. The composition of claim 45, wherein the amount is about 100 ppm to about 200 ppm.

50. The composition of claim 45, wherein the companion animal is a dog.

51. The composition of claim 45, wherein the companion animal is a cat.

52. A pet food composition comprising an effective amount of lipoic acid to increase the percentage of lean muscle mass in a companion animal, wherein said effective amount of lipoic acid to increase the percentage of lean muscle mass in a companion animal is at least about 25 ppm.

53. The composition of claim 52, wherein the amount is at least about 50 ppm.

54. The composition of claim 52, wherein the amount is at least about 100 ppm.

55. The composition of claim 52, wherein the amount is about 100 ppm to about 600 ppm.

56. The composition of claim 52, wherein the amount is about 100 ppm to about 200 ppm.

57. The composition of claim 52, wherein the companion animal is a dog.

58. The composition of claim 52, wherein the companion animal is a cat.

59. A pet food composition comprising an effective amount of lipoic acid wherein said effective amount of lipoic acid is at least 25 ppm.

60. The composition of claim 59, wherein the amount is at least about 50 ppm.

61. The composition of claim 59, wherein the amount is at least about 100 ppm.

62. The composition of claim 59, wherein the amount is about 100 ppm to about 600 ppm.

63. The composition of claim 59, wherein the amount is about 100 ppm to about 200 ppm.

64. The composition of claim 59, wherein the companion animal is a dog.

65. The composition of claim 59, wherein the companion animal is a cat.

66. The composition of claim 59, wherein the composition is useful for prevention or treatment of detrimental conditions in a companion animal in need thereof.

67. The composition of claim 66, wherein the detrimental conditions comprise degenerative joint condition, modulation of enzymatic degradation of articular cartilage, maintenance or decrease bone mineral density, kidney-related disorders, reduced palatability, unhealthy body composition, obesity, decreased percentage of lean muscle mass in a companion animal in need thereof.

68. The composition of claim 67, wherein the degenerative joint condition comprises osteoarthritis.

69. The composition of claim 67, wherein the degenerative joint condition comprises cartilage damage.

70. The composition of claim 67, where the obesity is treated or prevented by inducing weight loss in the companion animal.