ANALYTE MONITORING DEVICE AND METHODS OF USE

• US 20090210164A1
• Filed: 04/23/2009
• Published: 08/20/2009
• Est. Priority Date: 04/30/1998
• Status: Abandoned Application

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Heller, Ephraim, Heller, Adam, Say, James, Gal, Yoram, Colman, Fredric C., Aria, Behrad, Plante, Phillip John, Vreeke, Mark S., Friedman, Keith A., Tomasco, Michael F.
• Application Number:
  US12/428,826
• Publication Number:
  US 20090210164A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 5/7405 using sound
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61B 5/7445 Display arrangements, e.g. multiple display units
• CPC Class Codes: A61B 5/7455 characterised by tactile indication, e.g. vibration or electrical stimulation
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: C12Q 1/54 : involving glucose or galactose
• CPC Class Codes: G16H 10/40 : for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: H01L 23/3107 : the device being completely enclosed
• CPC Class Codes: H01L 23/49548 : Cross section geometry H01L23/49562 takes precedence
• CPC Class Codes: H01L 2924/00 : Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
• CPC Class Codes: H01L 2924/0002 : Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00
• CPC Class Codes: H01L 2924/19041 : being a capacitor
• CPC Class Codes: H01L 2924/3011 : Impedance
• CPC Class Codes: Y10S 128/903 : Radio telemetry
• CPC Class Codes: Y10T 29/49 : Method of mechanical manufacture
• CPC Class Codes: Y10T 29/49124 : On flat or curved insulated base, e.g., printed circuit, etc.

Abstract

An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

Claims

1-120. -120. (canceled)

121. A system for monitoring glucose concentration in a biological sample of a host, the system comprising:

a continuous glucose sensor that produces a data stream indicative of a host'"'"'s glucose concentration, wherein the continuous glucose sensor comprises a sensing region and a sensing membrane located over the sensing region;

an integrated receiver that receives the data stream from the continuous glucose sensor, wherein the integrated receiver comprises a housing, and wherein the housing comprises;

a processor module comprising programming to process the data stream received from glucose sensor;

a single point glucose monitor adapted to receive a biological sample from the host and measure the concentration of glucose in the sample, wherein electronics associated with the single point monitor are non-releasably located on the housing, wherein the single point glucose monitor further comprises a sensing region and a sensing membrane located over the sensing region; and

wherein the processor module further comprises programming to calibrate the data stream using the glucose concentration measured by the single point glucose monitor.

122. The system of claim 121, wherein the continuous glucose sensor comprises an electrochemical cell that measures the glucose concentration.

123. The system of claim 122, wherein the single point glucose monitor comprises an electrochemical cell that measures a concentration of glucose in the sample.

124. The system of claim 121, wherein the integrated receiver further comprises a user interface for displaying glucose concentration data from the continuous glucose sensor and the single point glucose monitor.

125. The system of claim 121, wherein the sensing membrane of each of the continuous sensor and the single point monitor comprise an enzyme domain, and wherein the enzyme domain of the sensing membrane of the continuous sensor and the enzyme domain of the sensing membrane of the single point monitor are substantially similar.

126. The system of claim 121, wherein the continuous glucose sensor and the single point glucose monitor use similar measurement technologies, and wherein the similar measurement technologies used for both the continuous glucose sensor and the single point glucose monitor comprise the same technology selected from the group consisting of enzymatic, chemical, and/or electrochemical technologies.

127. The system of claim 121, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

128. The system of claim 127, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

129. The system of claim 127, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

130. The system of claim 129, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

131. The system of claim 121, wherein the sensing membrane of the single point glucose monitor comprises two or more materials that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.

132. The system of claim 131, wherein the sensing membrane of the single point glucose monitor comprises three or more materials that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

133. The system of claim 121, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

134. The system of claim 121, wherein the sensing membrane comprises an enzyme.

135. A method for calibrating a continuous glucose sensor within an integrated receiver housing comprising a processor module comprising programming to process a data stream received from a continuous glucose sensor and a single point glucose monitor adapted to receive a biological sample from the host and measure the concentration of glucose in the sample, wherein each of the continuous sensor and the single point monitor comprise a sensing region comprising a sensing membrane, the method comprising:

continually receiving a data stream in the integrated receiver housing from a continuous glucose sensor;

measuring a glucose concentration of a biological sample using a single point glucose monitor, wherein electronics associated with the single point glucose monitor are non-releasably located on the integrated receiver housing; and

calibrating the data stream within the integrated receiver using the glucose concentration measured by the single point glucose monitor.

136. The method of claim 135, further comprising the step of:

displaying the glucose concentration measured by the single point glucose monitor.

137. The method of claim 135, further comprising the step of:

displaying a calibrated data stream.

138. The method of claim 135, wherein the sensing membrane of each of the continuous sensor and the single point monitor comprise an enzyme domain, and wherein the enzyme domain of the sensing membrane of the continuous sensor and the enzyme domain of the sensing membrane of the single point monitor are substantially similar.

139. The method of claim 135, wherein the continuous glucose sensor and the single point glucose monitor use similar measurement technologies, and wherein the similar measurement technologies used for both the continuous glucose sensor and the single point glucose monitor comprise the same technology selected from the group consisting of enzymatic, chemical, physical, and/or electrochemical.

140. The method of claim 136, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

141. The method of claim 140, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

142. The method of claim 140, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

143. The method of claim 142, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

144. The method of claim 135, wherein the sensing membrane of the single point glucose monitor comprises two or more materials and/or layers that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.

145. The method of claim 144, wherein the sensing membrane of the single point glucose monitor comprises three or more materials and/or layers that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

146. The method of claim 135, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

147. A system for calibrating a continuous glucose sensor data, the system comprising:

an integrated receiver comprising an integrated receiver housing, wherein the integrated receiver housing comprises;

a single point glucose monitor integral with the housing and adapted to measure a glucose concentration in a biological sample;

a receiver for receiving a data stream from a continuous glucose sensor;

a processor module comprising programming to calibrate the data stream from a continuous glucose sensor using the glucose concentration measured from the single point glucose monitor, wherein each of the continuous sensor and the single point monitor comprise a sensing region comprising a sensing membrane, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

148. The system of claim 147, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

149. The system of claim 147, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

150. The system of claim 149, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

151. The system of claim 147, further comprising a continuous glucose sensor, wherein the continuous glucose sensor produces a data stream indicative of a glucose concentration in a host, and wherein the continuous glucose sensor further comprises an electrochemical cell configured to measure the glucose concentration.

152. The system of claim 151, wherein the single point glucose monitor comprises an electrochemical cell configured to measure the glucose concentration in the biological sample.

153. The system of claim 151, further comprising a user interface configured to display glucose data from at least one of the continuous glucose sensor and the single point glucose monitor.

154. The system of claim 147, wherein the single point glucose monitor comprises at least two electrodes, wherein the sensing region of the single point glucose monitor is located within the integrated receiver.

155. The system of claim 147, wherein the sensing membrane of the single point glucose monitor comprises two or more materials that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.

156. The system of claim 155, wherein the sensing membrane of the single point glucose monitor comprises three or more materials that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

157. The system of claim 147, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

158. The system of claim 147, wherein the sensing membrane comprises an enzyme.

159. A system for calibrating a continuous glucose sensor data, the system comprising:

an integrated receiver comprising an integrated receiver housing, wherein the integrated receiver housing comprises;

a single point glucose monitor integral with the housing and adapted to measure a glucose concentration in a biological sample;

a receiver for receiving a data stream from a continuous glucose sensor;

a processor module comprising programming to calibrate the data stream from a continuous glucose sensor using the glucose concentration measured from the single point glucose monitor, wherein each of the continuous sensor and the single point monitor comprise a sensing region comprising a sensing membrane, wherein the sensing membrane of the single point glucose monitor comprises two or more materials that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.

160. The system of claim 159, wherein the sensing membrane of the single point glucose monitor comprises three or more materials that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

161. The system of claim 159, further comprising a continuous glucose sensor, wherein the continuous glucose sensor produces a data stream indicative of a glucose concentration in a host, and wherein the continuous glucose sensor further comprises an electrochemical cell configured to measure the glucose concentration.

162. The system of claim 159, wherein the single point glucose monitor comprises an electrochemical cell configured to measure the glucose concentration in the biological sample.

163. The system of claim 159, further comprising a user interface configured to display glucose data from at least one of the continuous glucose sensor and the single point glucose monitor.

164. The system of claim 159, wherein the single point glucose monitor comprises at least two electrodes, wherein the sensing region of the single point glucose monitor is located within the integrated receiver.

165. The system of claim 159, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

166. The system of claim 165, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

167. The system of claim 165, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

168. The system of claim 167, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

169. The system of claim 159, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

170. The system of claim 159, wherein the single point glucose monitor is integrally formed within the housing.

171. The system of claim 159, wherein the sensing membrane comprises an enzyme.

175. The system of claim 171, wherein the integrated receiver further comprises a user interface for displaying glucose concentration data from the continuous glucose sensor and the single point glucose monitor.

176. The system of claim 171, wherein the sensing membrane of each of the continuous sensor and the single point monitor comprise an enzyme domain, and wherein the enzyme domain of the sensing membrane of the continuous sensor and the enzyme domain of the sensing membrane of the single point monitor are substantially similar.

177. The system of claim 171, wherein the continuous glucose sensor and the single point glucose monitor use similar measurement technologies, and wherein the similar measurement technologies used for both the continuous glucose sensor and the single point glucose monitor comprise the same technology selected from the group consisting of enzymatic, chemical, and/or electrochemical technologies.

178. The system of claim 171, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

179. The system of claim 177, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

180. The system of claim 177, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

181. The system of claim 179, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

182. The system of claim 171, wherein the sensing membrane of the single point glucose monitor comprises two or more materials and/or layers that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.

183. The system of claim 181, wherein the sensing membrane of the single point glucose monitor comprises three or more materials and/or layers that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

184. The system of claim 171, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

186. The method of claim 184, further comprising the step of:

displaying the glucose concentration measured by the single point glucose monitor.

187. The method of claim 184, further comprising the step of:

displaying a calibrated data stream.

188. The method of claim 184, wherein the sensing membrane of each of the continuous sensor and the single point monitor comprise an enzyme domain, and wherein the enzyme domain of the sensing membrane of the continuous sensor and the enzyme domain of the sensing membrane of the single point monitor are substantially similar.

189. The method of claim 184, wherein the continuous glucose sensor and the single point glucose monitor use similar measurement technologies, and wherein the similar measurement technologies used for both the continuous glucose sensor and the single point glucose monitor comprise the same technology selected from the group consisting of enzymatic, chemical, and/or electrochemical technologies.

190. The method of claim 184, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

191. The method of claim 189, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

192. The method of claim 189, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

193. The method of claim 191, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

194. The method of claim 184, wherein the sensing membrane of the single point glucose monitor comprises two or more materials and/or layers that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.

195. The method of claim 193, wherein the sensing membrane of the single point glucose monitor comprises three or more materials and/or layers that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

196. The method of claim 184, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

198. The system of claim 196, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

199. The system of claim 196, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

200. The system of claim 198, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

201. The system of claim 196, further comprising a continuous glucose sensor, wherein the continuous glucose sensor produces a data stream indicative of a glucose concentration in a host, and wherein the continuous glucose sensor further comprises an electrochemical cell configured to measure the glucose concentration.

202. The system of claim 196, wherein the single point glucose monitor comprises an electrochemical cell configured to measure the glucose concentration in the biological sample.

203. The system of claim 196, further comprising a user interface configured to display glucose data from at least one of the continuous glucose sensor and the single point glucose monitor.

204. The system of claim 196, wherein the single point glucose monitor comprises at least two electrodes, wherein the sensing region of the single point glucose monitor is located within the integrated receiver.

205. The system of claim 196, wherein the sensing membrane of the single point glucose monitor comprises two or more materials and/or layers that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.

206. The system of claim 204, wherein the sensing membrane of the single point glucose monitor comprises three or more materials and/or layers that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

207. The system of claim 196, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

209. The system of claim 207, wherein the sensing membrane of the single point glucose monitor comprises three or more materials and/or layers that are the same as three or more materials of the sensing membrane of the continuous glucose sensor.

210. The system of claim 207, further comprising a continuous glucose sensor, wherein the continuous glucose sensor produces a data stream indicative of a glucose concentration in a host, and wherein the continuous glucose sensor further comprises an electrochemical cell configured to measure the glucose concentration.

211. The system of claim 207, wherein the single point glucose monitor comprises an electrochemical cell configured to measure the glucose concentration in the biological sample.

212. The system of claim 207, further comprising a user interface configured to display glucose data from at least one of the continuous glucose sensor and the single point glucose monitor.

213. The system of claim 207, wherein the single point glucose monitor comprises at least two electrodes, wherein the sensing region of the single point glucose monitor is located within the integrated receiver.

214. The system of claim 207, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

215. The system of claim 213, wherein an enzyme domain of the sensing membrane of the continuous glucose sensor and an enzyme domain of the sensing membrane of the single point glucose monitor comprise same materials.

216. The system of claim 213, wherein the sensing membrane of the single point glucose monitor comprises two or more domains and/or layers that are the same as two or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

217. The system of claim 215, wherein the sensing membrane of the single point glucose monitor comprises three or more domains and/or layers that are the same as three or more domains and/or layers of the sensing membrane continuous glucose sensor.

218. The system of claim 207, wherein the sensing region and/or the sensing membrane of the single point glucose monitor is located on a test strip configured to be releasably received by the single point glucose monitor.

172. A system for monitoring glucose concentration in a biological sample of a host, the system comprising:

a continuous glucose sensor that produces a data stream indicative of a host'"'"'s glucose concentration, wherein the continuous glucose sensor comprises a sensing region and a sensing membrane located over the sensing region;

an integrated receiver that receives the data stream from the continuous glucose sensor, wherein the integrated receiver comprises a housing, and wherein the housing comprises;

a processor module comprising programming to process the data stream received from glucose sensor; and

a single point glucose monitor adapted to receive a biological sample from the host and measure the concentration of glucose in the sample, wherein the single point monitor is non-releasably located on the housing, wherein the single point glucose monitor comprises a sensing region and a sensing membrane located over the sensing region;

wherein the processor module further comprises programming to calibrate the data stream using the glucose concentration measured by the single point glucose monitor.

173. The system of claim 172, wherein the continuous glucose sensor comprises an electrochemical cell that measures the glucose concentration.

174. The system of claim 173, wherein the single point glucose monitor comprises an electrochemical cell that measures a concentration of glucose in the sample.

185. A method for calibrating a continuous glucose sensor within an integrated receiver housing comprising a processor module comprising programming to process a data stream received from a continuous glucose sensor and a single point glucose monitor adapted to receive a biological sample from the host and measure the concentration of glucose in the sample, wherein each of the continuous sensor and the single point monitor comprise a sensing region comprising a sensing membrane, the method comprising:

continually receiving a data stream in the integrated receiver housing from a continuous glucose sensor;

measuring a glucose concentration of a biological sample using a single point glucose monitor non-releasably located on the integrated receiver housing; and

calibrating the data stream within the integrated receiver using the glucose concentration measured by the single point glucose monitor.

197. A system for calibrating a continuous glucose sensor data, the system comprising:

an integrated receiver comprising an integrated receiver housing, wherein the integrated receiver housing comprises;

a single point glucose monitor integrally formed within the housing and adapted to measure a glucose concentration in a biological sample;

a receiver for receiving a data stream from a continuous glucose sensor;

a processor module comprising programming to calibrate the data stream from a continuous glucose sensor using the glucose concentration measured from the single point glucose monitor, wherein each of the continuous sensor and the single point monitor comprise a sensing region comprising a sensing membrane, wherein the sensing membrane of the single point glucose monitor comprises one or more domains and/or layers that are the same as one or more domains and/or layers of the sensing membrane of the continuous glucose sensor.

208. A system for calibrating a continuous glucose sensor data, the system comprising:

an integrated receiver comprising an integrated receiver housing, wherein the integrated receiver housing comprises;

a single point glucose monitor integrally formed within the housing and adapted to measure a glucose concentration in a biological sample;

a receiver for receiving a data stream from a continuous glucose sensor;

a processor module comprising programming to calibrate the data stream from a continuous glucose sensor using the glucose concentration measured from the single point glucose monitor, wherein each of the continuous sensor and the single point monitor comprise a sensing region comprising a sensing membrane, wherein the sensing membrane of the single point glucose monitor comprises two or more materials and/or layers that are the same as two or more materials of the sensing membrane of the continuous glucose sensor.