USE OF MICRONEEDLES FOR SMALL MOLECULE METABOLITE REPORTER DELIVERY

• US 20090247984A1
• Filed: 10/24/2008
• Published: 10/01/2009
• Est. Priority Date: 10/24/2007
• Status: Abandoned Application

• Current Assignee: Cercacor Laboratories
• Original Assignee: Masimo Laboratories, Inc. (Masimo Corporation)
• Inventors: Young, Grace, Merritt, Sean, Lamego, Marcelo
• Application Number:
  US12/258,280
• Publication Number:
  US 20090247984A1
• Time in Patent Office: Days
• US Class Current: 604/506
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61K 49/0004 Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
• CPC Class Codes: A61K 49/0021 the fluorescent group being a small organic molecule
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

Systems that can include a microneedle array and a small molecule metabolic reporter are disclosed. The systems can be used to penetrate the epidermis and monitor the change in concentration of one or more metabolite or analyte.

Claims

1. A system for delivering at least one small molecule metabolic reporter (SMMR) into the human epidermis, comprising:

at least one SMMR; and

a microneedle array;

wherein said microneedle array penetrates said epidermis to facilitate delivery of said SMMR.

2. The system of claim 1, wherein the at least one SMMR comprises a compound of Formula (I):

3. An in vivo method for delivering at least one SMMR into the human epidermis, comprising:

contacting said SMMR with a microneedle array, and;

penetrating said epidermis with said array to a depth of about 10 μ

m, wherein said depth corresponds with the bottom of the dead stratum corneum layer, to about 175 μ

m, wherein said depth corresponds with the top of the dermal layer.

4. The method of claim 3, wherein the at least one SMMR comprises a compound of Formula (I):

5. The method of claim 3, wherein said microneedle array comprises solid microneedles.

6. The method of claim 5, wherein said contact between at least one SMMR and microneedle array comprises lining the array of microneedles with at least one SMMR.

7. The method of claim 5, wherein said contact between at least one SMMR and microneedle array comprises an array of microneedles with SMMR tips.

8. The method of claim 3, wherein said microneedle array comprises hollow microneedles.

9. The method of claim 8, wherein said contact between at least one SMMR and microneedle array comprises filling said hollow microneedles with at least one SMMR.

10. The method of claim 9, further comprising the step of injecting said at least one SMMR into the epidermis with a syringe.

11. The method of claim 3, wherein said contact between at least one SMMR and microneedle array comprises contacting said array with at least one SMMR applied directly to skin.

12. An in vivo method for monitoring the concentration of one or more metabolite or analyte, the method comprising:

contacting at least one SMMR with a microneedle array;

penetrating the human epidermis with said microneedles to a depth of about 10 μ

m, wherein said depth corresponds with the bottom of the dead stratum corneum layer, to about 175 μ

m, wherein said depth corresponds with the top of the dermal layer; and

monitoring a change in the concentration of the one or more metabolite or analyte in a metabolic pathway by detecting changes in the at least one SMMR at one or more time points using an optical reader.

13. The method of claim 12, wherein said one or more metabolite or analyte comprises glucose.

14. The method of claim 13, wherein the at least one SMMR comprises a compound of Formula (I):