Method for analyzing mitochondrial function
First Claim
1. A method for analyzing the mitochondrial function of a subject, comprising:
- 1) obtaining age, body fat percentage, weight and sex information from the subject;
2) calculating the subject'"'"'s predicted maximum oxygen consumption at a specified respiratory exchange ratio, the predicted maximum oxygen consumption being based on the subject'"'"'s sex, body fat percentage, weight and age in years, wherein the age in years of a subject over a predetermined age is a default age, and the age in years of a subject under a predetermined age is the subject'"'"'s actual age;
3) conducting a first test while the subject is breathing air having a first concentration of oxygen, the first test comprising;
a) measuring the subject'"'"'s average oxygen consumption at the specified respiratory exchange ratio when the subject is exercising; and
b) calculating a first energy quotient for the subject by dividing the subject'"'"'s average oxygen consumption measured in step 3a) by the subject'"'"'s predicted maximum oxygen consumption to obtain a first energy quotient for the subject;
4) conducting a second test while the subject is breathing air having a second concentration of oxygen, the first and second concentrations of oxygen being such that the amount of oxygen delivered to the subject'"'"'s mitochondria in the second test is 50% higher than the amount of oxygen delivered to the subject'"'"'s mitochondria in the first test, the second test comprising;
a) measuring the subject'"'"'s average oxygen consumption at the specified respiratory exchange ratio when the subject is exercising; and
b) calculating a second energy quotient for the subject by dividing the subject'"'"'s average oxygen consumption measured in step 4a) by the subject'"'"'s predicted maximum oxygen consumption; and
5) calculating a Mitochondrial Factor for the subject using the equation;
EQ1 being the first energy quotient and EQ2 being the second energy quotient, wherein the Mitochondrial Factor is directly proportional to the subject'"'"'s mitochondrial efficiency.
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Abstract
A method for analyzing the mitochondrial function of a subject involves: conducting a first test wherein the average oxygen consumption of the subject during exercise is measured while the subject is breathing air having a first oxygen concentration, preferably room air having a concentration of 20-21% by weight; conducting a second test wherein the average oxygen consumption of the subject during exercise is measured while the subject is breathing air having a second oxygen concentration, preferably air having an oxygen concentration of 30-33% by weight; measuring first and second energy quotients obtained from the first and second tests, respectively; and then using the energy quotients to calculate the subject'"'"'s Mitochondrial Factor. The Mitochondrial Factor is directly proportional to the subject'"'"'s mitochondrial efficiency and function. If conducted periodically, the method can be used to determine whether the subject'"'"'s mitochondrial efficiency is increasing or decreasing over time. The rate of increase or decrease will indicate the subject'"'"'s risk of developing one or more age-related diseases.
29 Citations
9 Claims
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1. A method for analyzing the mitochondrial function of a subject, comprising:
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1) obtaining age, body fat percentage, weight and sex information from the subject; 2) calculating the subject'"'"'s predicted maximum oxygen consumption at a specified respiratory exchange ratio, the predicted maximum oxygen consumption being based on the subject'"'"'s sex, body fat percentage, weight and age in years, wherein the age in years of a subject over a predetermined age is a default age, and the age in years of a subject under a predetermined age is the subject'"'"'s actual age; 3) conducting a first test while the subject is breathing air having a first concentration of oxygen, the first test comprising; a) measuring the subject'"'"'s average oxygen consumption at the specified respiratory exchange ratio when the subject is exercising; and b) calculating a first energy quotient for the subject by dividing the subject'"'"'s average oxygen consumption measured in step 3a) by the subject'"'"'s predicted maximum oxygen consumption to obtain a first energy quotient for the subject; 4) conducting a second test while the subject is breathing air having a second concentration of oxygen, the first and second concentrations of oxygen being such that the amount of oxygen delivered to the subject'"'"'s mitochondria in the second test is 50% higher than the amount of oxygen delivered to the subject'"'"'s mitochondria in the first test, the second test comprising; a) measuring the subject'"'"'s average oxygen consumption at the specified respiratory exchange ratio when the subject is exercising; and b) calculating a second energy quotient for the subject by dividing the subject'"'"'s average oxygen consumption measured in step 4a) by the subject'"'"'s predicted maximum oxygen consumption; and 5) calculating a Mitochondrial Factor for the subject using the equation; EQ1 being the first energy quotient and EQ2 being the second energy quotient, wherein the Mitochondrial Factor is directly proportional to the subject'"'"'s mitochondrial efficiency. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification