BIOACTIVE THERMOGELLING POLYMER SYSTEMS AND METHODS OF THEIR USE
First Claim
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1. A hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.
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Abstract
Hydrogels comprising poly(N-alkylacrylamide), poly(alkyleneglyco)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water are described, as well as methods of their preparation and use.
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Citations
92 Claims
- 1. A hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.
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41. A method of preparing a hydrogel comprising:
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(a) providing a mixture of N-allylacrylamide and poly(alkyleneglycol)di-acrylate or methacrylate in a solvent to form a first mixture; (b) adding a cross-linking agent, a source of calcium ions, and an initiator to the first mixture to form a second mixture; (c) polymerizing the second mixture for a time and at a temperature sufficient to cause polymerization to form a polymer; (d) drying the polymer; (e) pulverizing the polymer to form a powder; and (f) adding water to the powder - View Dependent Claims (42, 43, 44, 45, 46, 48, 49, 50)
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- 51. A method of repairing a vertebral fracture comprising injecting into the vicinity of the fracture a hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.
- 65. A method of reinforcing a vertebral bone structure comprising injecting into the vicinity of the bone structure a hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.
- 79. A method of resurfacing an articulating joint comprising providing to the joint a hydrogel comprising poly(N-alkylacrylamide), poly(alkyleneglycol)di-acrylate or methacrylate, cross-linking agent, a source of calcium ions, and water.
Specification