Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering purified quinic acid and/or carboxy alkyl ester

  • US 20090281180A1
  • Filed: 07/17/2009
  • Published: 11/12/2009
  • Est. Priority Date: 03/07/2002
  • Status: Active Grant
First Claim
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1. A method for enhancing the DNA repair process of a mammal by inhibiting TNF-α

  • production or inducing apoptosis of white blood cells, comprising administering to said mammal a pharmaceutical composition comprising a pharmaceutically effective amount of a purified, isolated quinic acid alkyl ester having a UV absorption maximum at approximately 200 nm and a bioassay efficacy using IC50 in HL-60 cells of less than 100 μ

    g/ml, and a nontoxic inert carrier or diluent in an amount effective to inhibit TNF-α

    production or to induce apoptosis of white blood cells, where said administration is other than topical.

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