Modified Fc molecules

  • US 20090286964A1
  • Filed: 08/01/2008
  • Published: 11/19/2009
  • Est. Priority Date: 09/24/2004
  • Status: Active Grant
First Claim
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1. A composition of matter of the formula

  • F1 (X2)b and multimers thereof, wherein;

    F1 is an IgG2 Fc domain comprising SEQ ID NO;

    606 modified so that it comprises at least one X3 inserted into or replacing all or part of a sequence selected from SEQ ID NOS;

    621, 622, 624, 632, 636, 639, 640, 642, 644, and 646 within a loop region of the IgG2 Fc domain, said loop region being in a non-terminal domain of the Fc domain;

    X1 and X2 are each independently selected from -(L1)n-P1, -(L1)c-P1-(L2)d-P2, -(L1)n-P1-(L2)d-P2-(L3)e-P3, and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)fP4;

    X3 is independently selected from -(L5)c-P5, -(L5)c-P5-(L6)d-P6, -(L5)c-P5-(L6)d-P6-(L7)e-P7, and -(L5)c-P5-(L6)d-P6-(L7)e-P7-(L8)f-P8;

    P1, P2, P3, and P4 are each independently sequences of pharmacologically active polypeptides or pharmacologically active peptides;

    P5, P6, P7, and P8 are each independently sequences of pharmacologically active peptides;

    L1, L2, L3, L4, L5, L6, L7, and L8 are each independently linkers; and

    a, b, c, d, e, and f are each independently 0 or 1.

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