REHYDRATABLE POLYSACCHARIDE PARTICLES AND SPONGE

• US 20090291911A1
• Filed: 04/23/2009
• Published: 11/26/2009
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Hitachi Displays Limited (Japan Display Incorporated)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Oliver, Dana A., Vaccaro, Brian, Myntti, Matthew Franco
• Granted Patent: US 8,802,652 B2
• Time in Patent Office: Days
• US Class Current: 514/55
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61K 31/718 Starch or degraded starch, e.g. amylose, amylopectin
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/0046 Ear
• CPC Class Codes: A61K 9/0085 Brain, e.g. brain implants; Spinal cord
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61L 2/007 Particle radiation, e.g. electron-beam, alpha or beta radiation
• CPC Class Codes: A61L 2/081 Gamma radiation
• CPC Class Codes: A61L 2/087 Particle radiation, e.g. electron-beam, alpha or beta radiation
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/56 : Porous materials, e.g. foams or sponges
• CPC Class Codes: C08B 15/005 : Crosslinking of cellulose derivatives
• CPC Class Codes: C08B 37/003 : Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
• CPC Class Codes: C08B 37/0042 : Carragenan or carragen, i.e. D-galactose and 3,6-anhydro-D-galactose, both partially sulfated, e.g. from red algae Chondrus crispus or Gigantia stellata; kappa-Carragenan; iota-Carragenan; lambda-Carragenan; Derivatives thereof
• CPC Class Codes: C08G 2210/00 : Compositions for preparing hydrogels
• CPC Class Codes: C08J 3/124 : Treatment for improving the free-flowing characteristics
• CPC Class Codes: C08L 1/26 : Cellulose ethers
• CPC Class Codes: C08L 1/286 : substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] C08L1/282 takes precedence
• CPC Class Codes: C08L 2666/26 : Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 5/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.

Claims

1. A composition comprising free-flowing rehydratable particles of substantially collagen-free dehydrothermally crosslinked polysaccharide.

2. A composition according to claim 1 wherein the particles contain substantially a single polysaccharide.

3. A composition according to claim 1 wherein the particles comprise a mixture of polysaccharides.

4. A composition according to claim 1 wherein the polysaccharide comprises cellulose, chitosan, agar, alginate, carrageenan, chitin, chondroitin sulfate, dextran, galactomannan, glycogen, hyaluronic acid, starch or mixture thereof.

5. A composition according to claim 1 wherein the polysaccharide comprises an oxidized polysaccharide or salt.

6. A composition according to claim 1 wherein the polysaccharide comprises carboxymethylcellulose.

7. A composition according to claim 1 wherein the polysaccharide is substantially only carboxymethylcellulose.

8. A composition according to claim 1 wherein the polysaccharide comprises chitosan.

9. A composition according to claim 8 wherein the chitosan is unmodified.

10. A composition according to claim 1 wherein the polysaccharide comprises a mixture of chitosan and another polysaccharide.

11. A composition according to claim 1 wherein the polysaccharide comprises a mixture of carboxymethylcellulose and chitosan.

12. A composition according to claim 1 further comprising a sealed syringe with which the particles can be rehydrated and dispensed.

13. An implantable article comprising a rehydratable porous sponge comprising substantially collagen-free dehydrothermally crosslinked polysaccharide.

14. A method for making a polysaccharide gel-forming composition, which method comprises:

a) providing a substantially collagen-free polysaccharide solution;

b) drying the solution to form a powder, and

c) dehydrothermally crosslinking the powder to form free-flowing particles that will provide a polysaccharide gel when rehydrated.

15. A method for making an implantable article, which method comprises:

a) providing a substantially collagen-free polysaccharide solution,

b) lyophilizing the solution to form a dried porous sponge, and

c) dehydrothermally crosslinking the sponge,

thereby forming an implantable article which will form a polysaccharide sponge when rehydrated.

16. A method for treating mucosal tissue and other body structures, which method comprises applying thereto a gel or sponge comprising rehydrated substantially collagen-free dehydrothermally crosslinked polysaccharide.

17. A method for converting a dry powdered composition to a gel, which method comprises:

a) dispersing free-flowing polysaccharide particles in a biocompatible water-miscible polar dispersant, and

b) combining the resulting dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel.