Pressure Sensitive Adhesive Composition Comprising Cross-Linked Polyalkylene Oxide and Water Absorbent Hydrophilic Agents

• US 20090306571A1
• Filed: 05/03/2007
• Published: 12/10/2009
• Est. Priority Date: 05/05/2006
• Status: Active Grant

• Current Assignee: Coloplast A/S
• Original Assignee: Coloplast A/S
• Inventors: Hansen, Kristoffer, Bach, Anders, Lykke, Mads, Lam, Peter Kwok Hing
• Granted Patent: US 8,076,528 B2
• Time in Patent Office: Days
• US Class Current: 602/56
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 24/0047 Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: C08L 1/08 Cellulose derivatives
• CPC Class Codes: C08L 1/28 Alkyl ethers
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 83/00 Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: C09J 171/02 Polyalkylene oxides
• CPC Class Codes: C09J 183/12 containing polyether sequences

Abstract

Accordingly, the present invention relates to a pressure sensitive adhesive composition consisting of a continuous phase comprising cross-linked polyalkyleneoxide polymer and a discontinuous phase comprising water absorbent hydrophilic agents wherein

• a) the water absorbent hydrophilic agent(s) is present in an amount between 1 and 40% w/w of the total adhesive composition; and
• b) the continuous phase comprises the reaction product (X) of:
  • (i) a polyalkyleneoxide polymer having one or more unsaturated end groups, and where more than 90% w/w of the polyalkylene oxide polymer consist of polymerised alkyleneoxide moities having three or more carbon atoms, and
  • (ii) an organosiloxane comprising one or more Si—H groups,
  • carried out in the presence of an addition reaction catalyst.

The present invention also relates to medical devices comprising such pressure sensitive adhesives.

Claims

1. A pressure sensitive adhesive composition consisting of a continuous phase comprising cross-linked polyalkyleneoxide polymer and a discontinuous phase comprising water absorbent hydrophilic agents characterized in that

a) the water absorbent hydrophilic agent(s) is present in an amount between 1 and 40% w/w of the total adhesive composition;

and

b) the continuous phase comprises the reaction product (X) of;

(i) a polyalkyleneoxide polymer having one or more unsaturated end groups, and where more than 90% w/w of the polyalkylene oxide polymer consist of polymerised alkyleneoxide moities having three or more carbon atoms, and

(ii) an organosiloxane comprising one or more Si—

H groups,

carried out in the presence of an addition reaction catalyst.

2. The pressure sensitive adhesive according to claim 1 wherein the amount of water absorbent hydrophilic agent(s) is 5-40% w/w, or more preferred 5-30% w/w of the total adhesive composition.

3. The pressure sensitive adhesive composition according to claim 1 wherein the continuous phase comprises the reaction product (Y) of:

(ia) a polyalkyleneoxide polymer having at least two unsaturated end groups, and where more than 90% w/w of the polyalkyleneoxide polymer consist of polymerised alkyleneoxide moities having three or more carbon atoms,

(iia) a polysiloxane cross-linking agent comprising 3 or more Si—

H groups and optionally (iiia) a polysiloxane chain extender comprising up to 2 Si—

H groups,

carried out in the presence of an addition reaction catalyst.

4. The adhesive composition according to claim 1 wherein the polyalkylene oxide polymer is polypropyleneoxide.

5. The pressure sensitive adhesive according to claim 1 wherein at least 60% w/w of the continuous phase consists of said reaction product.

6. The pressure sensitive adhesive composition according to claim 1 wherein the water absorbent hydrophilic agent(s) is selected from water swellable (non-water soluble) hydrocolloids or water soluble hydrocolloids.

7. The pressure sensitive adhesive composition according to claim 6 wherein the hydrocolloid is selected hydrocolloids of cross-linked polymers, such as cross-linked carboxymethyl cellulose.

8. The pressure sensitive adhesive composition according to claim 1 wherein the hydrocolloids having a particle size less than 20 microns, preferably below 5 microns, or more preferably below 2 microns.

9. A medical device comprising a pressure sensitive adhesive composition according to claim 1.

10. A medical device comprising a pressure sensitive adhesive composition according to claim 1 and a backing layer.

11. The medical device according to claim 10 wherein the backing layer is non-vapour permeable.

12. The medical device according to claim 10 wherein the backing layer is water vapour permeable and have a moisture vapour transmission rate above 500 g/m²/24 h.

13. The medical device according to claim 10, wherein the medical device comprises the adhesive composition in the form of a layer attached to said backing and wherein the adhesive composition comprises 5-30% w/w of water absorbent hydrophilic agent(s) and the backing layer has a moisture vapour transmission rate above 500 g/m²/24 h.

14. The medical device according to claim 13 wherein the medical device is a dressing.

15. The medical device according to claim 13 wherein the adhesive composition comprises 5-25% w/w, preferably 5-15% w/w, of water absorbent hydrophilic agent(s).

16. The medical device according to claim 13 wherein the thickness of the adhesive layer is between 50 and 250 μ

m where it is thickest.

17. The medical device according to claim 14 wherein the dressing is a wound dressing comprising an absorbent pad and the thickness of the adhesive layer is between 50 and 300 μ

m where it is thickest.

18. The medical device according to claim 10, wherein the medical device is an adhesive body side member for a two-piece ostomy appliance or an adhesive flange for a one-piece ostomy appliance where said adhesive body side member or said adhesive flange comprises a layer of said adhesive composition comprising 5-30% w/w of water absorbent hydrophilic agent(s) attached to said backing layer.

19. The medical device according to claim 10, wherein said pressure sensitive adhesive comprises 30-40% w/w of water absorbent hydrophilic agent(s).

20. The medical device according to claim 10, wherein where the medical device is an adhesive body side member for a two-piece ostomy appliance or an adhesive flange for a one-piece ostomy appliance where said adhesive body side member or said adhesive flange comprises a layer of said adhesive composition comprising 30-40% w/w of water absorbent hydrophilic agent(s) attached to said backing layer.

21. The medical device according to claim 18 wherein the thickness of the adhesive layer is between 0.5 and 1.5 mm where it is thickest.

22. The medical device according to claim 10 where the medical device is a dressing for exudating wounds comprising a layer of said adhesive composition attached to said backing layer, said adhesive composition comprising 30-40% w/w of water absorbent hydrophilic agent(s) and the backing layer has a moisture vapour transmission rate above 500 g/m²/24 h.

23. The medical device according to claim 22 wherein the thickness of the adhesive layer is between 200 μ

m and 1 mm where it is thickest.

24. The medical device according to claim 9 comprising element(s) inhibiting water vapour transmission and comprising a layer of said adhesive composition comprising 30-40% w/w of water absorbent hydrophilic agent(s).

25. The medical device according to claim 9 comprising element(s) inhibiting water vapour transmission where said element(s) is embedded in an adhesive body of said adhesive composition comprising 30-40% w/w of water absorbent hydrophilic agent.

26. The medical device according to claim 9 comprising one or more microelectronic systems and comprising a layer of said adhesive composition comprising 30-40% w/w of water absorbent hydrophilic agent(s).

27. The medical device according to claim 9 comprising one or more microelectronic systems wherein said microelectronic system(s) is embedded in an adhesive body of said adhesive composition comprising 30-40% w/w of water absorbent hydrophilic agent.

28. The adhesive device according to claim 26 wherein the microelectronic system(s) comprises components selected from communication component(s), CPU, power source, storage component(s), transducer component(s), actuator component(s) and mechanical and/or electrical interconnection between the components.

29. The adhesive device according to claim 26 wherein microelectronic system is a system enabling wireless communication.

30. The adhesive device according to claim 28 wherein the transducer has a detecting element selected from electrodes (polar, bipolar), a pressure sensor, a needle with an electrode, an accelerometer, a photo detector, a microphone, ISFET, an NTC resistor, a band gab detector, an ion membrane, an enzyme detector or a condenser.

31. The adhesive device according to claim 30 wherein the transducer has a non-invasive detecting element, such as electrodes, e.g. steel electrodes.

32. The adhesive device according to claim 30 wherein the transducer has an invasive detecting element, such as a needle containing an electrode.