POLYMER ENCAPSULATION AND/OR BINDING

• US 20100010103A1
• Filed: 12/12/2007
• Published: 01/14/2010
• Est. Priority Date: 12/20/2006
• Status: Active Grant

• Current Assignee: Arkema Incorporated (Arkema)
• Original Assignee: Arkema Incorporated (Arkema)
• Inventors: Mendolia, Michael S., Schmidt, Scott C., Callais, Peter A.
• Granted Patent: US 8,685,417 B2
• Time in Patent Office: Days
• US Class Current: 514/772.100
• CPC Class Codes: A61K 47/58 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C08F 2/38 Polymerisation using regulators, e.g. chain terminating agents , e.g. telomerisation
• CPC Class Codes: C08F 287/00 Macromolecular compounds obtained by polymerising monomers on to block polymers

Abstract

Encapsulation of and binding to pegylated bioactive molecules via functionalized comb, block, branched type polymers formed by nitroxide mediated controlled radical polymerization is disclosed.

Claims

1. A composition comprising:

a functional agent, and

a tailored polymer bound to or encapsulating said functional agent wherein said tailored polymer is formed via nitroxide mediated controlled radical polymerization.

2. The composition of claim 1 wherein said tailored polymer is a functional polyethylene glycol containing polymer wherein said functional agent is bound to the tailored polymer via one or more linking groups.

3. The composition of claim 1 wherein said functional agent is a bioactive material and said tailored polymer is a functional polyethylene glycol containing polymer.

4. The composition of claim 1 wherein said tailored polymer is a functional polyethylene glycol containing polymer having at least one end group comprising a linking group wherein said linking group is derived from alkoxyamines used as polymerization initiators.

5. The composition of claim 1 wherein said tailored polymer is a functional non-polyethylene glycol containing polymer.

6. The composition of claim 1 wherein said tailored polymer is a functional non-polyethylene glycol containing polymer comprising monomer units selected from hydrophilic units, hydrophobic units or mixtures thereof.

7. The composition of claim 1 wherein said tailored polymer is a functional non-polyethylene glycol containing polymer and said functional agent is selected from agrochemical agents, pharmaceutical agents or cosmetic agents.

8. The composition of claim 1 wherein said tailored polymer is an amphiphilic block copolymer.

9. The composition of claim 8 wherein said amphiphilic block copolymer contains at least one block segment which is a gradient copolymer.

10. The composition of claim 9 wherein said functional agent is selected from agrochemical agents, pharmaceutical agents, flavor or fragrance agents or cosmetic agents.

11. The composition of claim 1 wherein said tailored polymer is an amphiphilic block copolymer comprising at least one block segment which can crystallize and said functional agent is encapsulated but not covalently bound to said tailored polymer.

12. The composition of claim 11 wherein said at least one block segment which can crystallize is crystallized and is a gradient copolymer.

13. The composition of claim 11 wherein said amphiphilic block copolymer comprises at least on hydrophilic block segment and at least one hydrophobic block segment.

14. The composition of claim 1 wherein said tailored polymer is an amphiphilic block copolymer comprising at least one block segment which is a gradient copolymer and said functional agent is encapsulated but not covalently bound to said tailored polymer.

15. The composition of claim 1 wherein said tailored polymer is an amphiphilic block copolymer containing at least one hydrophilic block segment and at least one hydrophobic block segment.

16. The composition of claim 15 wherein:

at least one segment of said tailored polymer is a gradient copolymer;

said functional agent is hydrophobic or water insoluble; and

said functional agent is encapsulated but not covalently bound to said tailored polymer.

17. The composition of claim 15 wherein said tailored polymer is an ABC triblock copolymer.

18. The composition of claim 17 wherein one or more block segments is gradient.

19. The composition of claim 17 wherein one or both polymer segments B and C are hydrophobic.

20. The composition of claim 19 wherein at least one of polymer segments B and C can crystallize.

21. The composition of claim 14 wherein said hydrophobic block segment can crystallize.

22. The composition of claim 14, wherein said hydrophobic block segment can crystallize and is a gradient copolymer.

23. A process for producing a composition comprising a functional agent, and a tailored polymer bound to said functional group wherein said tailored polymer is formed via nitroxide mediated controlled radical polymerization comprising:

attaching an initiating alkoxyamine to said functional agent through a linking group to form a reactive agent,

reacting said reactive agent with at least one ethylenically unsaturated monomer to produce a polymer segment;

optionally, thereafter reacting said polymer segment with additionally at least one ethylenically unsaturated monomer to produce a block copolymer.

24. The process of claim 23 wherein said functional agent is bound to said tailored polymer in situ during processing.