ANALYTE SENSORS COMPRISING PLASTICIZERS

• US 20100030052A1
• Filed: 07/31/2008
• Published: 02/04/2010
• Est. Priority Date: 07/31/2008
• Status: Abandoned Application

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Le, Phu, Bommakanti, Balasubrahmanya S., Sandhu, Gary, Hoss, Udo
• Application Number:
  US12/183,602
• Publication Number:
  US 20100030052A1
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52

Abstract

A method and analyte-measurement device adapted to determine the concentration of an analyte in a fluid from a measurement site within a body, including an animal body, a mammalian body, or a human body. The invention further relates to the use of partially or fully implantable glucose-monitoring devices, including transcutaneous or subcutaneous glucose-monitoring devices. Devices, systems and kits making use of the aforementioned method are provided as well.

Claims

1. An analyte sensor comprising:

a working electrode comprising a sensing layer disposed proximate thereto;

a counter electrode; and

a plasticizer disposed proximate to the sensing layer.

2. The analyte sensor of claim 1, wherein at least a portion of the electrochemical analyte sensor is adapted to be subcutaneously positioned in a subject.

3. The analyte sensor of claim 1, further comprising a membrane disposed over the sensing layer.

4. The analyte sensor of claim 3, wherein the membrane comprises the plasticizer.

5. The analyte sensor of claim 1, wherein the sensing layer comprises the plasticizer.

6. The analyte sensor of claim 1, wherein the plasticizer comprises an alkyl citrate.

7. The analyte sensor of claim 6, wherein the alkyl citrate is triethyl citrate, acetyl triethyl citrate, tributyl citrate, acetyl tributyl citrate, trioctyl citrate, acetyl trioctyl citrate, trihexyl citrate, acetyl trihexyl citrate, butyryl trihexyl citrate, trihexyl o-butyryl citrate or trimethyl citrate.

8. The analyte sensor of claim 1, wherein the plasticizer comprises triethyl citrate.

9. The analyte sensor of claim 4, wherein the plasticizer comprises from about 0.005% to about 8% by weight of the total formulation of the membrane.

10. The analyte sensor of claim 4, wherein the plasticizer comprises from about 1% to about 40% by weight of the total formulation of the membrane.

11. The analyte sensor of claim 4, wherein the plasticizer comprises from about 15% to about 30% by weight of the total formulation of the membrane.

12. The analyte sensor of claim 5, wherein the plasticizer comprises from about 0.1% to about 40% by weight of the total formulation of the sensing layer.

13. The analyte sensor of claim 1, wherein the sensing layer comprises a glucose-responsive enzyme.

14. The analyte sensor of claim 1, wherein the sensing layer comprises a redox mediator.

15. The analyte sensor of claim 13, wherein the redox mediator comprises a ruthenium-containing complex or an osmium-containing complex.

16. The analyte sensor of claim 13, wherein the sensor is a glucose sensor.

17. The analyte sensor of claim 13, wherein the sensor is an in vivo sensor.

18. The analyte sensor of claim 13, wherein the sensor is an in vitro sensor.

19-41. -41. (canceled)