Sensing and interactive drug delivery

• US 20100049172A1
• Filed: 06/29/2009
• Published: 02/25/2010
• Est. Priority Date: 08/26/1998
• Status: Abandoned Application

• Current Assignee: Britton Chance
• Original Assignee: Britton Chance
• Inventors: Chance, Britton
• Application Number:
  US12/459,279
• Publication Number:
  US 20100049172A1
• Time in Patent Office: Days
• US Class Current: 604/890.100
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject.

Claims

1. an interactive drug delivery system comprising:

a drug delivery module constructed and arranged to deliver selected amounts of a drug into a subject;

an optical probe constructed and arranged to detect in vivo in a selected tissue region of said subject a manifestation caused by the delivered drug; and

a local controller constructed and arranged to receive data from or transmit data to said optical probe and said drug delivery module;

said local controller being arranged to correlate optical data received from said optical probe to selected data and provide signals to said drug delivery module for adjusting the amounts of the drug to be delivered into said subject.

2. The system of claim 1 further including a central controller remotely located from and in wireless communication with said local controller, central controller constructed and arranged to receive data from said local controller and provide to said local controller data for adjusting the amounts of said drug to be delivered into said subject.

3. The system of claim 1 further including a temperature probe coupled to said local controller.

4. The system of claim 3 wherein said temperature probe uses an infra-red beam to measure a local temperature of a tissue region.

5. The system of claim 1 further including an electrical probe coupled to said local controller.

6. The system of claim 1 wherein said optical probe is a time-resolved (TRS) system.

7. The system of claim 1 wherein said optical probe is a phase modulation system.

8. The system of claim 1 wherein said optical probe is a phased array.

9. The system of claim 1 wherein said optical probe is phase cancellation system.

10. The system of claim 1 wherein said optical probe is an amplitude cancellation system.

11. The system of claim 1 wherein said drug delivery module includes an electrical controller designed to regulate the rate of the delivered drug based on the signals from said local controller.

12. An interactive drug delivery method comprising:

delivering by a drug delivery module selected amounts of a drug into a subject;

optically detecting in vivo in a selected tissue region of said subject a manifestation caused by the delivered drug by an optical probe;

receiving data from or transmitting data to said optical probe and said drug delivery module by a local controller;

correlating data received from said optical probe to selected data stored in said local controller; and

providing signals to said drug delivery module for adjusting the amounts of the drug to be delivered into said subject.

13. The interactive drug delivery method of claim 12 further including regulating the rate of the delivered drug based on signals from said local controller.

14. The interactive drug delivery method of claim 12 including measuring tissue temperature.

15. The interactive drug delivery method of claim 14 wherein said measuring temperature includes using an infra-red beam for measuring a local temperature of a tissue region.

16. The interactive drug delivery method of claim 12 further including measuring electrical signals with an electrical probe.

17. An interactive drug delivery system comprising:

a drug delivery module constructed and arranged to deliver selected amounts of a drug into a subject;

an optical probe including a light source and a light detector constructed and arranged to examine in vivo in a selected biological tissue region of said subject during the operation of said drug delivery module, said optical probe being constructed to detect optical signal related to a manifestation in the examined biological tissue region caused by the delivered drug in the tissue region; and

a local controller constructed and arranged to communicate with said optical probe and said drug delivery module;

said local controller being arranged to correlate data related to said manifestation with selected data and provide signals to said drug delivery module for adjusting the amounts of the drug to be delivered into said subject.

18. The system of claim 17 wherein said optical probe includes a time-resolved spectroscopy (TRS) system.

19. The system of claim 17 wherein said optical probe includes a phase modulation system.

20. The system of claim 17 wherein said optical probe includes a phased array.

21. The system of claim 17 wherein said optical probe includes phase cancellation system.

22. The system of claim 17 wherein said optical probe includes an amplitude cancellation system.

23. The system of claim 17 said optical probe includes an array of optical input ports optically coupled to several light sources and an array of detection ports optically coupled to several light detectors.

24. The system of claim 17 said optical probe is constructed to detect said optical signal including fluorescent light emitted as manifestation of said delivered drug.

25. The system of claim 17 further including a central controller remotely located from and in wireless communication with said local controller, central controller constructed and arranged to receive data from said local controller and provide to said local controller data for adjusting the amounts of said drug to be delivered by said drug delivery module into said subject.

26. The system of claim 17, wherein said optical probe is further constructed to detect infra-red light to measure a local temperature of a tissue region.

27. The system of claim 26 wherein said local controller is constructed and arranged to receive said local temperature data provide to said drug delivery module data for adjusting the amounts of said drug to be delivered into said subject.