Medical Systems and Methods of Use

• US 20100056993A1
• Filed: 07/16/2007
• Published: 03/04/2010
• Est. Priority Date: 07/21/2006
• Status: Active Grant

• Current Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Original Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Inventors: Chase, H. Peter
• Granted Patent: US 9,962,112 B2
• Time in Patent Office: Days
• US Class Current: 604/66
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

This invention provides ambulatory medical systems that include a monitoring device, a therapeutic substance administering device, and a receiver-controller for receiving a signal generated by the monitoring device and controlling the therapeutic substance administering device based on the information received from the monitoring device. The invention also provides methods for using the same.

Claims

1. A medical system comprising:

a monitoring device comprising an electronic control circuitry that is configured to monitor a selected state of the body, wherein said monitoring device further comprises a telemetry system;

a therapeutic substance delivery device comprising an electronic control circuitry that is configured to deliver a therapeutic substance to a patient; and

a receiver-controller device comprising an electronic circuitry that is configured to receive a signal generated by said monitoring device and is further configured to control the operation of said therapeutic substance delivery device based on the signal generated by said monitoring device.

2. The medical system of claim 1, wherein said monitoring device monitors the glucose level of the patient.

3. The medical system of claim 2, wherein said therapeutic substance delivery device is configured to administer insulin to the patient.

4. The medical system of claim 3, wherein said receiver-controller is configured to reduce or stop administering insulin under a warning condition, wherein the warning condition is selected from the following glucose concentration conditions:

(a) the glucose level is 130-150 mg/dl and the glucose level decreases at a rate of 2 mg/dl-min or higher;

(b) the glucose level is from about 100 mg/dl to about 130 mg/dl and the glucose level decreases at a rate of from about 1 to about 2 mg/dl-min or higher; and

(c) the glucose level is 70 mg/dl or lower.

5. The medical system of claim 4 further comprising an alarm system for providing a signal to the patient during the warning condition, wherein the signal is audible, visible, tactile, or a combination thereof.

6. The medical system of claim 1, wherein said telemetry system comprises a wireless transmitter for transmitting a signal to said receiver-controller device.

7. The medical system of claim 1, wherein said monitoring device measures subcutaneous glucose level.

8. The medical system of claim 1, wherein said monitoring device measures blood glucose level.

9. A method for treating diabetes in a patient comprising

monitoring the glucose level in a patient with a monitoring device comprising an electronic control circuitry that is configured to monitor the glucose level in the patient, wherein the monitoring device further comprises a telemetry system;

and

reducing or ceasing insulin administration to the patient when the glucose level in the patient falls within a warning condition using a therapeutic substance delivery device comprising an electronic control circuitry that is configured to control the administration of insulin to a patient,

wherein the operation of the therapeutic substance delivery device is controlled by a receiver-controller device comprising an electronic circuitry that is configured to receive a signal generated by the monitoring device and is further configured to control the therapeutic substance delivery device based on the signal generated by the monitoring device.

10. The method of claim 9 further comprising providing a warning signal to the patient when the glucose level falls within the warning condition.

11. The method of claim 10, wherein the warning condition comprises one of the following conditions:

(a) the glucose level measured by the monitor is at about 130-150 mg/dl or lower and the rate of glucose level decrease as measured by the monitor is about 2 mg/dl-min or higher;

(b) the glucose level measured by the monitor is from about 100 mg/dl to about 130 mg/dl and the rate of glucose level decrease as measured by the monitor is 1 mg/dl-min or higher;

or

(c) the glucose level measured by the monitor is about 70 mg/dl or less.

12. The method of claim 10, wherein the warning signal comprises audio, visual, tactile, or a combination thereof.

13. The method of claim 9, wherein said step of monitoring glucose level comprises measuring subcutaneous glucose level of the patient.

14. The method of claim 9, wherein said step of monitoring glucose level comprises measuring blood glucose level of the patient.

15. A method for administering insulin to a subject comprising:

monitoring the glucose level in a patient with a monitoring device comprising an electronic control circuitry that is configured to monitor the glucose level in the patient, wherein the monitoring device further comprises a telemetry system; and

delivering insulin to the patient when the glucose level in the patient falls within a warning condition using a therapeutic substance delivery device comprising an electronic control circuitry that is configured to control administration of insulin to a patient,

wherein the operation of the therapeutic substance delivery device is controlled by a receiver-controller device comprising an electronic circuitry that is configured to receive a signal generated by the monitoring device and is further configured to control the therapeutic substance delivery device based on the signal generated by the monitoring device.