METHODS FOR TREATING CACHEXIA AND LYMPHOPENIA
First Claim
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1. A method of treating, ameliorating, preventing, or delaying the onset of cachexia in a patient comprising:
- administering isolated or purified CD4+ T cells to the patient.
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Abstract
Disappearance of a cell population, designated CD4+ CD44v.low, has been shown to be associated with cachexia and lymphopenia, and those conditions can be treated or delayed by administering those cells to a patient. In addition, disclosed are assays for those cells for diagnosing or prognosticating cachexia and/or lymphopenia and the end of the honeymoon period in Type I diabetes. Furthermore, disclosed herein are methods related to the use of CD4+ CD44v.low cells in promoting insulin-secreting beta cell mass.
9 Citations
49 Claims
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1. A method of treating, ameliorating, preventing, or delaying the onset of cachexia in a patient comprising:
administering isolated or purified CD4+ T cells to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- 19. An isolated T cell population, comprising an isolated population of T cells characterized as CD4+ CD44v.low.
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21. A method of inhibiting or reversing lymphopenia in a patient comprising:
administering isolated or purified CD4+ T cells to the patient. - View Dependent Claims (22, 23, 24)
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25. A method of treating, ameliorating or preventing diabetes in a patient comprising:
administering isolated CD4+ T cells to the patient. - View Dependent Claims (26, 27)
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28. A method for diagnosing cachexia in a patient, comprising:
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identifying a patient at risk for cachexia; determining a level of CD4+ CD44v.low T cells in a biological sample from said patient; and assessing whether the amount of CD4+ CD44v.low T cells is at a level which is lower than a predetermined level.
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29. A method for diagnosing the onset of a honeymoon period in a patient suffering from Type 1 diabetes, comprising:
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identifying a patient with Type 1 diabetes prior to said honeymoon period; determining a level of CD4+ CD44v.low T cells in a biological sample from said patient; and assessing whether the amount of CD4+ CD44v.low T cells is at a level which is higher than a predetermined level.
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30. A method for diagnosing the loss of a honeymoon period in a patient suffering from Type 1 diabetes, comprising:
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identifying a patient with Type 1 diabetes within said honeymoon period; determining a level of CD4+ CD44v.low T cells in a biological sample from said patient; and assessing whether the amount of CD4+ CD44v.low T cells is at a level which is lower than a predetermined level.
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31. A method for monitoring the progress of a cachexia therapy in a patient comprising:
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identifying a patient with cachexia; providing said subject a cachexia therapy; determining a level of CD4+ CD44v.low T cells in a biological sample in said patient, before a treatment with said cachexia therapy and during or after a period of said treatment.
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32. A method for determining the response to a cachexia therapy in a patient comprising:
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identifying a patient with a cachexia; providing said patient a cachexia therapy; and determining a level of CD4+ CD44v.low T cells in a biological sample in said patient, before a treatment with said cachexia therapy and during or after a period of said treatment.
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33. A method for promoting the responsiveness to a therapy for a disorder:
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identifying a patient with the disorder; administering isolated or purified CD4+ T cells to the patient; - View Dependent Claims (34, 35, 36, 37, 38)
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39. A method of identifying a patient likely to be responsive to a therapy for a disorder comprising:
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identifying a patient with said disorder; determining a level of CD4+ CD44v.low T cells in a biological sample from said patient; and assessing whether the amount of CD4+ CD44v.low T cells is at a level which is greater than a predetermined level. - View Dependent Claims (40, 41)
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42. A method for promoting the onset of the honeymoon period in Type 1 diabetes, comprising:
administering isolated or purified CD4+ T cells to the patient. - View Dependent Claims (43, 44)
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45. A method for delaying the loss of the honeymoon period in Type 1 diabetes, comprising:
administering isolated or purified CD4+ T cells to the patient. - View Dependent Claims (46, 47)
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48. A method of treating, ameliorating or preventing diabetes in a patient comprising:
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isolating or purifying pancreatic islets from said patient or other donor; growing said islets in culture in the presence of CD4+ T cells; and transplanting said islets into said patient. - View Dependent Claims (49)
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Specification