Frozen compositions and methods for piercing a substrate

• US 20100114348A1
• Filed: 09/15/2009
• Published: 05/06/2010
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC A Limited Liability Corporation of The State of Delaware
• Inventors: Myhrvold, Nathan P., Boyden, Edward S., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C., Cook, Daniel B.
• Granted Patent: US 8,798,933 B2
• Time in Patent Office: Days
• US Class Current: 700/97
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/54 characterised by the route of administration
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7088 Compounds having three or more nucleosides or nucleotides
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/38 Albumins
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 38/4886 Metalloendopeptidases (3.4.24), e.g. collagenase
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/12 Viral antigens
• CPC Class Codes: A61K 39/145 Orthomyxoviridae, e.g. influenza virus
• CPC Class Codes: A61K 41/0004 Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 : Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0021 : Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/007 : Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/08 : Solutions composition of solutions A61K47/00
• CPC Class Codes: A61K 9/12 : Aerosols; Foams A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015
• CPC Class Codes: A61K 9/143 : with inorganic compounds
• CPC Class Codes: A61K 9/1611 : Inorganic compounds
• CPC Class Codes: A61K 9/1641 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1664 : Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617
• CPC Class Codes: A61K 9/1688 : resulting in pure drug agglomerate optionally containing up to 5% of excipient
• CPC Class Codes: A61K 9/19 : lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00
• CPC Class Codes: A61K 9/209 : containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61K 9/2095 : Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: A61K 9/2866 : Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61M 2037/0023 : Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 : having a lumen
• CPC Class Codes: A61M 2205/02 : characterised by a particular materials
• CPC Class Codes: A61M 37/0015 : by using microneedles
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/16 : for influenza or rhinoviruses
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: B33Y 80/00 : Products made by additive manufacturing
• CPC Class Codes: C07K 16/22 : against growth factors ; against growth regulators
• CPC Class Codes: C07K 16/283 : against Fc-receptors, e.g. CD16, CD32, CD64 CD23 C07K16/2851
• CPC Class Codes: C07K 16/2842 : against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
• CPC Class Codes: C07K 16/2878 : against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
• CPC Class Codes: C07K 16/30 : from tumour cells
• CPC Class Codes: C12N 2760/16034 : Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 30/40 : for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/20 : for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/50 : for simulation or modelling of medical disorders
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10T 83/222 : With receptacle or support for cut product

Abstract

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

Claims

1. A computer-implemented method comprising:

accepting a first input associated with at least one parameter for making at least one frozen particle composition or frozen piercing implement;

accepting a second input associated with at least one parameter for administering the at least one frozen particle composition or frozen piercing implement to at least one substrate;

processing the first input and the second input; and

generating an output to a user readable display.

20. The computer-implemented method of claim 1, further comprising accepting a third input associated with at least one feature of the at least one subject.

36. The computer-implemented method of claim 1, further comprising transmitting one or more signals that include information related to the processing of the first input and the second input.

41. The computer-implemented method of claim 1, further comprising making or administering at least one frozen particle composition or frozen piercing implement.

2-19. -19. (canceled)

21-35. -35. (canceled)

37-40. -40. (canceled)

42. (canceled)

43. The computer-implemented method of claim 42, further comprising evaluating the at least one substrate for one or more indicators related to at least one parameter for administering the at least one frozen particle composition or frozen piercing implement.

47. The computer-implemented method of claim 43, further comprising transmitting one or more signals that include information relating to the accepting a first input or a second input and information related to the evaluating the at least one substrate.

44-46. -46. (canceled)

48-49. -49. (canceled)

50. A system comprising:

means for accepting a first input associated with at least one parameter for making at least one frozen particle composition or frozen piercing implement;

means for accepting a second input associated with at least one parameter for administering the at least one frozen particle composition or frozen piercing implement to at least one substrate;

means for processing the first input and the second input; and

means for generating an output to a user readable display.

62. The system of claim 50, further comprising means for accepting a third input associated with at least one feature of the at least one subject.

81. The system of claim 50, further comprising means for transmitting one or more signals that include information related to the processing of the first input and the second input.

86. The system of claim 50, further comprising means for making or administering at least one frozen particle composition or frozen piercing implement.

88. The system of claim 50, further comprising means for evaluating the at least one substrate for one or more indicators related to at least one parameter for administering the at least one frozen particle composition or frozen piercing implement.

51-61. -61. (canceled)

63-80. -80. (canceled)

82-85. -85. (canceled)

87. (canceled)

89-94. -94. (canceled)

95. A computer-implemented method comprising:

receiving one or more signals that include information related to accepting input associated with at least one parameter for making or administering at least one frozen particle composition or frozen piercing implement to at least one substrate;

wherein the at least one frozen particle composition or frozen piercing implement includes at least one agent;

receiving one or more signals that include information related to evaluating the at least one substrate for one or more indicators of administration of the at least one frozen particle composition, or frozen piercing implement;

processing the information related to the input associated with at least one parameter for making or administering the at least one frozen particle composition or frozen piercing implement to at least one substrate and the information related to the evaluating the at least one substrate; and

generating an output to a user readable display.

105. The computer-implemented method of claim 95, wherein the output includes one or more instructions for making the at least one frozen particle composition or frozen piercing implement.

96-104. -104. (canceled)

106-114. -114. (canceled)

115. A system comprising:

means for receiving one or more signals that include information related to accepting input associated with at least one parameter for making or administering at least one frozen particle composition or frozen piercing implement to at least one substrate, the frozen particle composition or frozen piercing implement including at least one agent;

means for receiving one or more signals that include information related to evaluating the at least one substrate for one or more indicators of administration of the at least one frozen particle composition, frozen piercing implement, or agent;

means for processing the information related to the input associated with at least one parameter for making or administering the at least one frozen particle composition or frozen piercing implement to at least one substrate and the information related to the evaluating the at least one substrate; and

means for generating an output to a user readable display.

121. The system of claim 115, wherein the means for receiving one or more signals includes means for receiving one or more signals associated with selection of at least one parameter for making the at least one frozen particle composition or frozen piercing implement.

125. The system of claim 115, wherein the output includes one or more instructions for making the at least one frozen particle composition or frozen piercing implement.

116-120. -120. (canceled)

122-124. -124. (canceled)

126-134. -134. (canceled)

135. A computer-implemented method comprising:

accepting a first input associated with at least one parameter for making at least one frozen piercing implement device;

accepting a second input associated with at least one parameter for administering the at least one frozen piercing implement device to at least one substrate;

processing the first input and the second input; and

generating an output to a user readable display.

136. The computer-implemented method of claim 135, wherein the at least one frozen piercing implement device includes at least one of a frozen piercing implement array device, frozen piercing implement fluidic device, or frozen piercing implement injection device.

152. The computer-implemented method of claim 135, further comprising accepting a third input associated with at least one feature of the at least one subject.

171. The computer-implemented method of claim 135, further comprising transmitting one or more signals that include information related to the processing the first input and the second input.

176. The computer-implemented method of claim 135, further comprising making or administering at least one frozen piercing implement device.

178. The computer-implemented method of claim 135, further comprising evaluating the at least one substrate for one or more indicators related to at least one parameter for administering the at least one frozen piercing implement device.

137-151. -151. (canceled)

153-170. -170. (canceled)

172-175. -175. (canceled)

177. (canceled)

179. -184. (canceled)

185. A system comprising:

means for accepting a first input associated with at least one parameter for making at least one frozen piercing implement device;

means for accepting a second input associated with at least one parameter for administering the at least one frozen piercing implement device to at least one substrate;

means for processing the first input and the second input; and

means for generating an output to a user readable display.

186. The system of claim 185, wherein the at least one frozen piercing implement device includes at least one of a frozen piercing implement array device, frozen piercing implement fluidic device, or frozen piercing implement injection device.

187. The system of claim 185, wherein the frozen piercing implement injection device includes a frozen piercing implement auto-injection device.

188. The system of claim 185, wherein the means for processing the first input and the second input includes means for electronically processing the first input and the second input.

189. The system of claim 185, wherein the means for processing the first input and the second input includes means for electronically processing the first input and the second input by utilizing one or more of Gaussian smoothing, scaling, homomorphic filtering, parametric estimation techniques, Boolean operations, Monte Carlo simulations, wavelet based techniques, mirroring, smoothing, gradient weighted partial differential equation smoothing, NURBS, polygonal modeling, splines and patches modeling, algorithmic execution, logical decision-making, result prediction, Finite Element Analysis, or modification of a CAD design.

201. The system of claim 185, further comprising means for accepting a third input associated with at least one feature of the at least one subject.

220. The system of claim 185, further comprising means for transmitting one or more signals that include information related to the means for processing the first input and the second input.

227. The system of claim 185, further comprising means for making or administering at least one frozen piercing implement device.

229. The system of claim 185, further comprising means for evaluating the at least one substrate for one or more indicators related to at least one parameter for administering the at least one frozen piercing implement device.

233. The system of claim 185, further comprising means for transmitting one or more signals that include information relating to the accepting a first input or a second input and information related to the evaluating the at least one substrate.

190-200. -200. (canceled)

202-219. -219. (canceled)

221-226. -226. (canceled)

228. (canceled)

230-232. -232. (canceled)

234-235. -235. (canceled)

236. A computer-implemented method comprising:

receiving one or more signals that include information related to accepting input associated with at least one parameter for making or administering at least one frozen particle composition, frozen piercing implement, or frozen piercing implement device to at least one substrate;

wherein the at least one frozen particle composition, frozen piercing implement, or frozen piercing implement device includes at least one agent;

receiving one or more signals that include information related to evaluating the at least one substrate for one or more indicators of administration of the at least one frozen particle composition, frozen piercing implement, frozen piercing implement device or agent;

processing the information related to the input associated with at least one parameter for making or administering the at least one frozen particle composition, frozen piercing implement, or frozen piercing implement device to at least one substrate and the information related to the evaluating the at least one substrate; and

generating an output to a user readable display.

237-257. -257. (canceled)

258. A system comprising:

means for receiving one or more signals that include information related to accepting input associated with at least one parameter for making or administering at least one frozen particle composition, frozen piercing implement, or frozen piercing implement device to at least one substrate;

wherein the at least one frozen particle composition, frozen piercing implement or frozen piercing implement device includes at least one agent;

means for receiving one or more signals that include information related to evaluating the at least one substrate for one or more indicators of administration of at least one frozen piercing implement device or agent;

means for processing the information related to the input associated with at least one parameter for making or administering the at least one frozen piercing implement device to at least one substrate and the information related to the evaluating the at least one substrate; and

means for generating an output to a user readable display.

259. The system of claim 258, wherein the at least one frozen piercing implement device includes at least one of a frozen piercing implement device, frozen piercing implement fluidic device, or frozen piercing implement injection device.

272. The system of claim 258, wherein the output includes one or more instructions for making the at least one frozen particle composition, frozen piercing implement, or frozen piercing implement device.

260-271. -271. (canceled)

273-281. -281. (canceled)