• US 20100125049A1
  • Filed: 12/11/2009
  • Published: 05/20/2010
  • Est. Priority Date: 02/26/2003
  • Status: Active Grant
First Claim
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1. A composition comprising a plurality of conjugates, each conjugate comprising one, two or three water-soluble polymers each covalently attached to a Factor VIII moiety via a hydrolytically stable linkage, the composition characterized by an in-vitro activity of the conjugates of at least about 15% relative to that of the same Factor VIII moiety in unconjugated form, when evaluated under the same conditions and at an equivalent dosage amount as the unconjugated Factor VIII moiety using the same in-vitro model.

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