METHODS AND DEVICES FOR INTRADERMAL INJECTION
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Accused Products
Abstract
Devices and methods for intradermal (ID) administration of diagnostic and therapeutic agents, vaccines and other compounds into the dermal layer of the skin are disclosed. The devices and the methods simplify the ID injection process and increase the consistency of the placement of the needle tip in the dermal space close to the skin surface allowing for a shallow cannula placement in the dermis. Furthermore, the devices and methods broaden the number of sites suitable for ID injection and make the ID injection possible with limited training.
136 Citations
66 Claims
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1-33. -33. (canceled)
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34. An adapter (100, 200, 310, 410, 510) for use with a syringe (50, 80, 350) provided with a needle cannula (55, 85, 345, 431, 531) for intradermal injection of a medicament into the skin of a patient comprising:
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a body sized to receive in sliding engagement the needle cannula for movement of the needle cannula relative to the body between a first position and a second position; a first primary skin contacting surface (104, 204, 323) positioned at a distal end of the body and containing an opening sized to receive the needle cannula; and a second primary skin contacting surface (105, 205, 311) positioned at the distal end of the body and further positioned at an angle (123, 223, 324) to the first skin contacting surface between approximately 100 degrees and approximately 165 degrees, wherein; in the first position, the needle cannula is positioned relative to the body such that at least a tip of the needle cannula is retracted within the opening; in the second position the tip of the needle cannula extends through the opening; in the second position, the needle cannula extends axially in a direction substantially parallel to at least a portion of the second primary skin contacting surface. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A method of making an intradermal injection into the skin comprising the steps of:
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providing an intradermal needle assembly comprising a needle cannula with a forward needle tip and an integral adapter surrounding the needle cannula, the adapter having a first skin contacting surface and a second skin contacting surface and the needle cannula being in fluid communication with a drug delivery device; engaging the first and second skin contacting surfaces with the skin; inserting the needle cannula into the dermis layer of the skin through an opening in the first skin contacting surface, wherein the needle cannula is further inserted in the dermis generally parallel to the second skin contacting surface; expelling a fluid from the drug delivery device into the dermis; and removing the intradermal needle assembly from the skin. - View Dependent Claims (58, 59, 60, 61)
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62. A method of making an intradermal injection into the skin comprising the steps of:
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providing an intradermal needle assembly having a forward needle tip and an integral adapter surrounding the needle cannula, the adapter having two surfaces for contacting the skin and the needle cannula being in fluid communication with a drug delivery device; engaging the contact surfaces of the adapter with the skin and maintaining contact of the skin with both adapter contact surfaces; slightly turning the needle hub CCW as defined by the hub pin position to enable distal travel of the hub; inserting the needle into the dermis layer of the skin through an opening in one of the contact surfaces, wherein the needle cannula enters the dermis through the first surface and is further inserted in general parallel to the skin surface; expelling the compound from the drug delivery device into the dermis; and
removing, shielding, and discarding the needle assembly. - View Dependent Claims (63)
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64. A method of making an intradermal injection into the skin comprising the steps of:
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providing an intradermal needle assembly having a forward needle tip, an integral adapter surrounding the needle cannula and a dermis sensor, the adapter having two surfaces for contacting the skin and the needle cannula being in fluid communication with a drug delivery device; engaging the contact surfaces of the adapter with the skin and maintaining contact of the skin with both adapter contact surfaces; activating the dermis sensor while contacting the skin and maintaining the contact; inserting the needle into the dermis layer of the skin through an opening in one of the contact surfaces, wherein the needle cannula enters the dermis through the first surface and is further inserted generally parallel to the skin surface; expelling the compound from the drug delivery device into the dermis; and removing and shielding the cannula whereby the assembly is permanently disabled for safe discard. - View Dependent Claims (65)
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66. A method for providing an intradermal injection, comprising:
- contacting a skin surface with first and second skin contacting surfaces of an adapter device having a drug delivery device mounted in an internal cavity, the first and second skin contacting surfaces being arranged at an angle of less than 180°
relative to one another;
inserting a needle cannula of the drug delivery device through an opening in the adapter device and into the skin; and
extending the needle cannula through the dermal layer along a path generally parallel to and below the second skin contacting surface.
- contacting a skin surface with first and second skin contacting surfaces of an adapter device having a drug delivery device mounted in an internal cavity, the first and second skin contacting surfaces being arranged at an angle of less than 180°
Specification