Hypoglycemic Activity of Osthole

• US 20100168224A1
• Filed: 12/31/2008
• Published: 07/01/2010
• Est. Priority Date: 12/31/2008
• Status: Active Grant

• Current Assignee: Taipei Medical University WAN Fan Hospital (Government of The Republic of China)
• Original Assignee: Taipei Medical University WAN Fan Hospital (Government of The Republic of China)
• Inventors: Chen, Yu-Chien, Liu, Der-Zen, Hung, Ling-Fang, Liang, Yu-Chih, Chen, Nai-Qi, Lin, Pei-Jung
• Granted Patent: US 8,198,320 B2
• Time in Patent Office: Days
• US Class Current: 514/457
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48

Abstract

The present invention relates to a method for controlling blood glucose level and a method for the prophylaxis or treatment of diabetes mellitus and/or its complications. The present invention further relates to an anti-diabetic formulation for controlling blood glucose level and/or for the prophylaxis or treatment of diabetes mellitus and/or its complications.

Claims

1. A method for controlling blood glucose level comprising administering a therapeutically effective amount of osthole or a pharmaceutically acceptable derivative thereof to a subject in need thereof, thereby reducing the blood glucose level in the subject.

2. The method according to claim 1, wherein the therapeutically effective amount is about 10 to about 200 mg/kg/day.

3. The method according to claim 1, wherein the therapeutically effective amount is about 50 mg/kg/day.

4. The method according to claim 1, wherein the osthole or pharmaceutically acceptable derivative thereof is administered to the subject parenterally or orally.

5. The method according to claim 1, wherein the subject is a mammal.

7. The method according to claim 1, wherein the blood glucose level is elevated due to diabetes mellitus.

8. The method according to claim 1, further comprising administering a second agent effective for controlling blood glucose level.

9. The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained by chemically synthesized or extracted from osthole-containing plants.

10. The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium plant.

11. The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium monnieri (L.) Cuss.

12. The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium fruit.

6. The method according to claim 6, wherein the mammal is a human.

13. A method for the prophylaxis or treatment of diabetes mellitus and/or its complications comprising administering a therapeutically effective amount of osthole or a pharmaceutically acceptable derivative thereof to a subject in need thereof.

14. The method according to claim 13, wherein the therapeutically effective amount is about 10 to about 200 mg/kg/day.

15. The method according to claim 13, wherein the therapeutically effective amount is about 50 mg/kg/day.

16. The method according to claim 13, wherein the osthole or pharmaceutically acceptable derivative thereof is administered to the subject parenterally or orally.

17. The method according to claim 13, wherein the subject is a mammal.

18. The method according to claim 13, wherein the mammal is a human.

19. The method according to claim 13, wherein the diabetes mellitus is Type I.

20. The method according to claim 13, wherein the diabetes mellitus is Type II.

21. The method according to claim 13, further comprising administering a second agent effective for the prophylaxis or treatment of diabetes mellitus.

22. The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained by chemically synthesized or extracted from osthole-containing plants.

23. The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium plant.

24. The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium monnieri (L.) Cuss.

25. The method according to claim 13, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium fruit.