BRAIN STATE ANALYSIS BASED ON SELECT SEIZURE ONSET CHARACTERISTICS AND CLINICAL MANIFESTATIONS
First Claim
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1. A method of developing a brain state advisory system, comprising:
- deriving a brain state advisory algorithm, the deriving step comprising;
analyzing patient EEG data,identifying within the EEG data pro-ictal states correlated with clinical electrographic seizures, andgenerating pro-ictal state alerts corresponding to pro-ictal states preferentially correlated with clinical electrographic seizures over pro-ictal states correlated with subclinical electrographic seizures;
andplacing the advisory algorithm in memory of the brain state advisory system.
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Abstract
Systems and methods for developing a brain state analysis system using subject EEG data are provided. The analysis system distinguishes clinical from subclinical electrographic seizures and optionally distinguishes among different seizure onset characteristics. An algorithm trained on only clinical electrographic seizures may predict clinical seizures more accurately with fewer perceived false positives. In addition, algorithms trained on a particular onset condition may distinguish and advise on that onset condition when used by the patient.
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31 Claims
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1. A method of developing a brain state advisory system, comprising:
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deriving a brain state advisory algorithm, the deriving step comprising; analyzing patient EEG data, identifying within the EEG data pro-ictal states correlated with clinical electrographic seizures, and generating pro-ictal state alerts corresponding to pro-ictal states preferentially correlated with clinical electrographic seizures over pro-ictal states correlated with subclinical electrographic seizures; and placing the advisory algorithm in memory of the brain state advisory system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A brain state system comprising:
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an advisory system having a controller programmed to generate a pro-ictal state alert preferentially correlated with clinical electrographic seizures over subclinical electrographic seizures; and an alert indicator communicating with the controller to indicate the pro-ictal state alert. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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18. A method of treating a subject comprising:
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obtaining an EEG dataset from the subject; identifying a pro-ictal state preferentially correlated with a clinical electrographic seizure over a subclinical electrographic seizure; and generating a pro-ictal state alert corresponding to the pro-ictal state identified in the identifying step. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method of developing a seizure prediction system, comprising:
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analyzing a patient EEG data set including clinical electrographic seizures and subclinical electrographic seizures; and developing a seizure prediction algorithm for predicting seizures based on brain states preferentially correlated with clinical electrographic seizures over subclinical electrographic seizures. - View Dependent Claims (31)
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Specification