Methods For Immobilizing Anti-Thrombogenic Material Onto A Medical Device Or Into A Coating Thereon
First Claim
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1. A method for immobilizing an anti-thrombogenic material into a coating posited on a surface of an implantable medical device within the mammalian body, comprising:
- preparing a base coat mixture for application to the surface of the medical device;
polymerizing the base coat mixture to form a base coat layer on the medical device;
performing a reaction between the base coat layer and excess amine-terminated polyethylene glycol;
rinsing the base coat layer with water; and
performing a reaction between the anti-thrombogenic material and amine-terminated polyethylene glycol on the surface of the medical device.
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Abstract
The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.
70 Citations
26 Claims
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1. A method for immobilizing an anti-thrombogenic material into a coating posited on a surface of an implantable medical device within the mammalian body, comprising:
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preparing a base coat mixture for application to the surface of the medical device; polymerizing the base coat mixture to form a base coat layer on the medical device; performing a reaction between the base coat layer and excess amine-terminated polyethylene glycol; rinsing the base coat layer with water; and performing a reaction between the anti-thrombogenic material and amine-terminated polyethylene glycol on the surface of the medical device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 24)
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12. A method for immobilizing an anti-thrombogenic material into a coating posited on a surface of an implantable medical device within the mammalian body, comprising:
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preparing a base coat mixture for application to the surface of the medical device; polymerizing the base coat mixture to form a base coat layer on the medical device; and performing a reaction between a coupling solution and chemically functional groups within the base coat layer of the device surface. - View Dependent Claims (13, 14, 15, 25)
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16. A method for immobilizing an anti-thrombogenic material into a coating posited on a surface of an implantable medical device within the mammalian body, comprising:
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preparing a base coat mixture for application to the surface of the medical device; polymerizing the base coat mixture to form a base coat layer on the surface of the medical device; immobilizing the anti-thrombogenic material directly to chemically functional groups within the base coat layer on the surface of the medical device; and performing a carbodiimide-mediated reaction to form an amide linkage to a chemical chain of the anti-thrombogenic material attached to the base coat layer. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 26)
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Specification