Implantable Sensor
1 Assignment
0 Petitions
Accused Products
Abstract
Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient'"'"'s body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described.
51 Citations
61 Claims
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1. (canceled)
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5. (canceled)
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8-10. -10. (canceled)
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11. A method, comprising:
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implanting in a human subject live cells that are genetically engineered to produce a protein; and determining a physiological parameter of the subject by sensing from within the subject a characteristic of the protein. - View Dependent Claims (13, 14, 15, 19, 20, 51, 52, 55, 56, 57, 58)
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12. (canceled)
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16-18. -18. (canceled)
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21-24. -24. (canceled)
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25. Apparatus, comprising:
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an implantable chamber that comprises live cells that are genetically engineered to produce and secrete a protein; and an implantable sensor adapted to sense a characteristic of the protein and to generate a signal, in response to the sensed characteristic, that is indicative of a physiological parameter of a subject. - View Dependent Claims (2, 3, 4, 6, 7, 28, 36, 37, 39, 47, 48, 49, 50, 59, 60, 61)
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26-27. -27. (canceled)
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29-35. -35. (canceled)
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38. (canceled)
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40-46. -46. (canceled)
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53-54. -54. (canceled)
Specification