TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER

  • US 20100209421A1
  • Filed: 02/18/2010
  • Published: 08/19/2010
  • Est. Priority Date: 10/14/2005
  • Status: Active Grant
First Claim
Patent Images

1. A method for treating a breast condition in a subject, comprising administering to a breast tissue of the subject, a composition that inhibits PAX2 expression and/or PAX2 activity,wherein said composition comprises one or more ingredients selected from the group consisting of polynucleotides encoding an siRNA for PAX2, polynucleotides that inhibits binding of PAX2 to DEFB1 promoter, antagonists of angiotensin II, antagonists of angiotensin II receptor, antagonists of angiotensin-converting enzyme (ACE), antagonists of mitogen-activated protein kinase (MEK), antagonists of extracellular signal-regulated kinase 1,2 (ERK1,2), antagonists of signal transducer and activator of transcription 3 (STAT3), and blockers of the RAS signaling pathway.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×