METHOD AND APPARATUS TO CALCULATE DIABETIC SENSITIVITY FACTORS AFFECTING BLOOD GLUCOSE
First Claim
1. An apparatus comprising:
- (a) memory for storing a database comprising at least initial one data set, the initial data set comprising (1) a first blood glucose reading taken at a first measurement time, (2) a second blood glucose reading taken at a second measurement time following an interval after the first measurement time, (3) the insulin dose administered to the individual during the interval, and (4) a measure of the food intake by the individual during the interval;
(b) means for transforming the at least one initial data set to generate at least one transformed data set comprising a pair of transformed variables, the first transformed variable of the pair being the difference between the first blood glucose reading and the second blood glucose reading divided by the food intake measure, and the second transformed variable of the pair being the insulin dose divided by the food intake measure;
(c) means for determining parameters of a functional relationship between the transformed variables and converting said parameters of the functional fit to an estimate of the individual'"'"'s at least one diabetic sensitivity factor; and
(d) means for communicating the at least one diabetic sensitivity factor.
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Abstract
Methods and apparatus are provided for determining a diabetic patient'"'"'s carbohydrate to insulin ratio (CIR), carbohydrate to blood glucose ratio (CGR), and insulin sensitivity factor (ISF) using the patient'"'"'s record of blood glucose readings, carbohydrate consumption and insulin doses. The method provides the sensitivity factors that best account for the patient'"'"'s observed blood glucose changes by linear regression of appropriately transformed variables. An apparatus that can collect and store the blood glucose readings, insulin dosages, and carbohydrate intake data and process these data according to this invention can generate statistically characterized sensitivity factors to advise the diabetic patient on optimal bolus insulin dosages.
201 Citations
22 Claims
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1. An apparatus comprising:
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(a) memory for storing a database comprising at least initial one data set, the initial data set comprising (1) a first blood glucose reading taken at a first measurement time, (2) a second blood glucose reading taken at a second measurement time following an interval after the first measurement time, (3) the insulin dose administered to the individual during the interval, and (4) a measure of the food intake by the individual during the interval; (b) means for transforming the at least one initial data set to generate at least one transformed data set comprising a pair of transformed variables, the first transformed variable of the pair being the difference between the first blood glucose reading and the second blood glucose reading divided by the food intake measure, and the second transformed variable of the pair being the insulin dose divided by the food intake measure; (c) means for determining parameters of a functional relationship between the transformed variables and converting said parameters of the functional fit to an estimate of the individual'"'"'s at least one diabetic sensitivity factor; and (d) means for communicating the at least one diabetic sensitivity factor. - View Dependent Claims (2, 3)
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4. An apparatus comprising:
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(a) a data processor for executing a programmed set of instructions; (b) a memory device accessible to the data processor for storing a database comprising at least initial one data set, the initial data set comprising (1) a first blood glucose reading taken at a first measurement time, (2) a second blood glucose reading taken at a second measurement time following an interval after the first measurement time, (3) the insulin dose administered to the individual during the interval, and (4) a measure of the food intake by the individual during the interval; (c) a first set of instructions for the data processor for transforming the at least one initial data set to generate at least one transformed data set comprising a pair of transformed variables, the first transformed variable of the pair being the difference between the first blood glucose reading and the second blood glucose reading divided by the food intake measure, and the second transformed variable of the pair being the insulin dose divided by the food intake measure; (d) a second set of instructions for the data processor for determining parameters of a functional relationship between the transformed variables and converting said parameters of the functional fit to an estimate of the individual'"'"'s at least one diabetic sensitivity factor; and (e) an input/output device for communicating the at least one diabetic sensitivity factor. - View Dependent Claims (5, 6)
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7. A method of determining at least one diabetic sensitivity factor of an individual based on at least one initial data set, the initial data set comprising (1) a first blood glucose reading taken at a first measurement time, (2) a second blood glucose reading taken at a second measurement time following an interval after the first measurement time, (3) the insulin dose administered to the individual during the interval, and (4) a measure of the food intake by the individual during the interval, the method comprising:
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a) transforming the at least one initial data set to generate at least one transformed data set comprising a pair of transformed variables, the first transformed variable of the pair being the difference between the first blood glucose reading and the second blood glucose reading divided by the food intake measure, and the second transformed variable of the pair being the insulin dose divided by the food intake measure; and b) determining parameters of a functional relationship between the transformed variables and converting said parameters of the functional fit to an estimate of the individual'"'"'s at least one diabetic sensitivity factor. - View Dependent Claims (8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21)
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14. (canceled)
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22. (canceled)
Specification