Process and Device for Determining Recommendations for Active Ingredient Dosages on the Basis of Series of Measurements of at Least One Physiological Parameter of a Patient

• US 20100271213A1
• Filed: 04/23/2010
• Published: 10/28/2010
• Est. Priority Date: 04/23/2009
• Status: Abandoned Application

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Krainz, Michael, Leiner, Marco Jean Pierre
• Application Number:
  US12/766,455
• Publication Number:
  US 20100271213A1
• Time in Patent Office: Days
• US Class Current: 340/573.100
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients

Abstract

A process comprises performing a series of measurements of at least one physiological parameter, in particular a blood value, such as, e.g., blood sugar, on a patient, wherein samples are taken from the patient at discrete measuring times, with the measurements being performed on those samples. A recommendation for a dosage of an active ingredient to be administered to the patient until the next measuring time is determined from the measurements, for which purpose a dosage proposal algorithm incorporating the at least one measured physiological parameter is applied. As a result, it is possible to adjust at least one physiological parameter of the patient to a target range or keep it in the target range, respectively. The dosage proposal algorithm is configured such that the next measuring time is determined in consideration of measurement exclusion time windows and is optionally reported to the person in charge.

Claims

1. A process for carrying out a series of measurements of at least one physiological parameter, including a blood sugar value, on samples taken from a patient at discrete measuring times and for calculating a recommendation for a dosage of at least one active ingredient to be administered to the patient until the next measuring time on the basis of a dosage proposal algorithm incorporating the at least one measured physiological parameter, whereby at least one physiological parameter of the patient is adjusted to a target range, the next measuring time being determined by considering measurement exclusion time windows.

2. The process according to claim 1, wherein the dosage proposal algorithm includes patient data, such as weight, food habits etc., in the calculation of the recommendation.

3. The process according to claim 2, wherein the determined next measuring time represents a variable of the dosage proposal algorithm.

4. The process according to claim 3, wherein the next measuring time is determined by adding a time interval to the latest measuring time and checking whether the preliminary next measuring time resulting therefrom lies in a measurement exclusion time window and, if applicable, the next measuring time is shifted outside of the measurement exclusion time window.

5. The process according to claim 4, wherein the shifting of the next measuring time outside of the measurement exclusion time window is carried out subject to precalculating a measured value to be expected, in particular by interpolation, and by assessing the risk whether the measured value to be expected is acceptable for the condition of the patient.

6. The process according to claim 5, wherein assessing the risk results in a finding of an unduly high risk, an alert information is output.

7. The process according to claim 6, wherein the measuring time is shifted to before the measurement exclusion time window.

8. The process according to claim 4, wherein the shifting of the next measuring time outside of the measurement exclusion time window is carried out considering the risk of a maximum admissible time span between two measuring times for the condition of the patient is being assessed.

9. The process according to claim 8, wherein assessing the risk results in a finding of an unduly high risk, an alert information is output.

10. The process according to claim 9, wherein the measuring time is shifted to before the measurement exclusion time window.

11. The process according to claim 1, wherein the measurement exclusion time window is caused by actions of the analyzer, the next measuring time is determined by adding a time interval to the latest measuring time and checking whether the next measuring time resulting therefrom lies within the measurement exclusion time window and the measurement exclusion time window caused by the measuring device is shifted outside of the next measuring time.

12. The process according to claim 1, wherein the measurement exclusion time window is caused by actions of the user, the next measuring time is determined by adding a time interval to the latest measuring time and checking whether the next measuring time resulting therefrom lies within the measurement exclusion time window and a meassage is transmitted to the user in which he or she is asked to shift the time of his or her actions and hence the measurement exclusion window caused by the user outside of the next measuring time.

13. A process according to claim 12, wherein the user shifts the measurement exclusion window caused by the user outside of the next measuring time and shifts subsequent measurement exclusion windows which are caused by the user.

14. A medical-diagnostic blood analyzer for receiving samples taken from a patient at discrete measuring times, comprising:

at least one measuring sensor for measuring at least one physiological blood parameter of the samples,

an arithmetic unit receiving measuring signals of the at least one measuring sensor for processing measured values of the at least one physiological blood parameter from the measuring signals, for calculating a recommendation for a dosage of an active ingredient to be administered to the patient until the next measuring time on the basis of a dosage proposal algorithm incorporating the at least one measured physiological parameter, wherein the arithmetic unit includes instructions therein causing the analyzer to;

calculate a recommendation for a dosage of at least one active ingredient to be administered to the patient until a next measuring time on the basis of a dosage proposal algorithm incorporating the at least one measured physiological blood parameter, whereby at least one physiological blood parameter of the patient is adjusted to a target range, and

determining the next measuring time by considering measurement exclusion time windows.

15. The analyzer according to claim 14, further including an output interface by which the arithmetic unit outputs the dosage recommendation, alerts, and other messages to a user.

16. The analyzer according to claim 14, wherein the arithmetic unit performs the calculating and determining steps for a plurality of patients in parallel.

17. A medical-diagnostic blood analyzer, comprising:

at least one measuring sensor for measuring at least one physiological blood parameter of the samples,

an arithmetic unit including instructions therein causing the analyzer to;

receive measuring signals of the at least one measuring sensor taken from a patient at discrete measuring times,

process the measuring signals to determine measured values of the at least one physiological blood parameter;

calculate a recommendation for a dosage of an active ingredient to be administered to the patient until the next measuring time on the basis of a dosage proposal algorithm incorporating the at least one measured physiological blood parameter, whereby at least one physiological parameter of the patient is adjusted to a target range, and

determining the next measuring time by considering measurement exclusion time windows.

18. The analyzer of claim 17, further comprising an output interface by which the arithmetic unit outputs the dosage recommendation, alerts, and other messages to a user.

19. The analyzer according to claim 17, wherein the arithmetic unit performs the calculating and determining steps for a plurality of patients in parallel.

20. A medical-diagnostic blood analyzer, comprising:

at least one measuring sensor for measuring at least one physiological blood parameter of the samples,

an arithmetic unit including instructions therein causing the analyzer to;

receive measuring signals of the at least one measuring sensor taken from a patient at discrete measuring times,

process the measuring signals to determine measured values of the at least one physiological blood parameter;

determining a desired next measuring time;

determining whether the desired next measuring time falls within a measurement exclusion time window;

if the desired next measuring time falls within a measurement exclusion time window, providing for adjustment of one of the desired measuring time and the measurement exclusion time window such that the desired measuring time does not fall within the measurement exclusion time window;

defining the desired next measuring time as the recommended measuring time once the desired measuring time does not fall within the measurement exclusion time window; and

calculate a recommendation for a dosage of at least one active ingredient to be administered to the patient until a next measuring time on the basis of a dosage proposal algorithm incorporating the at least one measured physiological blood parameter, whereby at least one physiological parameter of the patient is adjusted to a target range.