AMINE-DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF

• US 20100273841A1
• Filed: 04/23/2010
• Published: 10/28/2010
• Est. Priority Date: 04/23/2009
• Status: Active Grant

• Current Assignee: Shionogi & Co., Ltd.
• Original Assignee: Shionogi & Co., Ltd.
• Inventors: SAKAGAMI, Masahiro, OKUNO, Takayuki
• Granted Patent: US 8,227,618 B2
• Time in Patent Office: Days
• US Class Current: 514/367
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: C07D 231/38 Nitrogen atoms nitro radicals C07D231/16
• CPC Class Codes: C07D 263/58 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• CPC Class Codes: C07D 277/82 Nitrogen atoms

Abstract

This invention provides an anorectic or anti-obesity composition comprising a compound of the formula (I):

• • formula (I):

a pharmaceutically acceptable salt or solvate thereof,
wherein

• R¹ is optionally substituted lower alkyl,
• Y is —S(O)n- wherein n is 1 or 2, or —CO—,
• R² is hydrogen or lower alkyl,
  • R⁷ is hydrogen or lower alkyl,
• X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, and
• Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like.

Claims

1. A compound selected from the group consisting of:

4. An anorectic or anti-obesity composition comprising a compound or pharmaceutically acceptable salt thereof according to claim 1.

5. A method for suppressing appetite, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

6. A method for treatmenting obesity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

7. A method for treatmenting an obesity-related disorder, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

8. A method for weight management for obesity, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

9. A method for inducing weight loss, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

10. A method for accelerating weight loss, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

11. A method for maintaining body weight, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

12. A method for managing body weight, comprising administering an effective amount of a compound or pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.

2. A pharmaceutical composition, comprising a compound selected from the group consisting of:

3. A pharmaceutical composition according to claim 2, exhibiting NPY Y5 receptor antagonistic activity.