INTRA-SESSION CONTROL OF TRANSCRANIAL MAGNETIC STIMULATION

• US 20100298623A1
• Filed: 10/24/2008
• Published: 11/25/2010
• Est. Priority Date: 10/24/2007
• Status: Abandoned Application

• Current Assignee: Cervel Neurotech, Inc.
• Original Assignee: Cervel Neurotech, Inc.
• Inventors: Schneider, M. Bret, Mishelevich, David J.
• Application Number:
  US12/680,749
• Publication Number:
  US 20100298623A1
• Time in Patent Office: Days
• US Class Current: 600/13
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 2/008 for pain treatment or analgesia
• CPC Class Codes: A61N 2/02 using magnetic fields produced by coils, including single turn loops or electromagnets A61N2/12 takes precedence

Abstract

Described herein are methods for controlling Transcranial Magnetic Stimulation during or within a session, where direct immediate patient reported feedback is utilized to assess the effect and optimize the treatment in real time. These methods may be applicable to superficial repetitive Transcranial Magnet Stimulation (rTMS) or deep-brain stereotactic Transcranial Magnetic Stimulation (sTMS). Examples of therapies that may benefit from these methods include TMS treatment of: acute pain (e.g., during dental procedures or bunionectomies), depression, or Parkinson'"'"'s Disease, to name only a few. TMS systems and devices including or more patient inputs that may be used to perform these methods are also described.

Claims

1. A patient-configurable Transcranial Magnetic Stimulation (TMS) method that allows a patient to dynamically modify the TMS while a TMS procedure is being performed, the method comprising:

applying Transcranial Magnetic Stimulation to a first site in the patient'"'"'s brain, at a first magnetic field intensity and a first stimulation frequency;

changing one or more of the site, intensity or the frequency of the TMS stimulation based on input from the patient, wherein the patient changes one or more of the site, intensity or frequency of the TMS stimulation based on the patient'"'"'s experience of the applied TMS stimulation; and

applying Transcranial Magnetic Stimulation to the patient at the new site, intensity or frequency of TMS stimulation.

2. The method of claim 1, further comprising providing a stimulus to prompt a patient experience that is modified during the TMS procedure.

3. The method of claim 2, wherein the stimulus comprises a visual stimulus.

4. The method of claim 2, wherein the stimulus comprises a tactile stimulus.

5. The method of claim 1, wherein the step of changing one or more of the site, intensity or the frequency of the TMS stimulation comprises allowing the patient to manipulate a handheld control to alter one or more of the site, intensity or frequency of the TMS stimulation.

6. The method of claim 5, wherein the patient may alter the site, intensity or frequency of the TMS stimulation only within a predetermined range for each of the site, intensity or frequency.

7. The method of claim 1, wherein the step of changing one or more of the site, intensity or the frequency of the TMS stimulation is performed while applying Transcranial Magnetic Stimulation to the patient.

8. A patient-configurable Transcranial Magnetic Stimulation (TMS) method that allows a patient to dynamically modify the TMS while a TMS procedure is being performed, the method comprising:

positioning a plurality of TMS electromagnets to apply electromagnetic energy to a deep brain target site;

applying TMS to the target site at a magnetic field intensity and a stimulation frequency;

enabling the patient to change one or more of the position of the TMS electromagnet, the intensity of the TMS stimulation, or the frequency of the TMS stimulation based the patient'"'"'s experience of the applied TMS stimulation; and

applying Transcranial Magnetic Stimulation to the patient at the changed position of the TMS electromagnet, intensity of the TMS stimulation, or frequency of TMS stimulation.

9. The method of claim 8, further comprising providing a stimulus to prompt a patient experience that is modified during the TMS procedure.

10. The method of claim 9, wherein the stimulus comprises a visual stimulus.

11. The method of claim 9, wherein the stimulus comprises a tactile stimulus.

12. The method of claim 8, wherein the step of enabling the patient to change one or more of the position of the TMS electromagnet, the intensity of the TMS stimulation, or the frequency of the TMS stimulation comprises allowing the patient to manipulate a handheld control.

13. A system for applying Transcranial Magnetic Stimulation (TMS), the system comprising:

at least one TMS electromagnet configured to apply TMS to a site in a patient'"'"'s brain;

a controller configured to control the TMS electromagnet to apply TMS to the site in a patient'"'"'s brain at a magnetic field intensity and a frequency of stimulation; and

a patient feedback input connected to the controller, configured to allow the patient to adjust one or more of the site of application of the TMS in the patient'"'"'s brain, the magnetic field intensity of the applied TMS, or the frequency of the TMS stimulation during a TMS procedure on the patient.

14. The system of claim 13, wherein the at least one TMS electromagnet comprises a plurality of TMS electromagnets configured to be positioned to apply TMS to a site in a patient'"'"'s brain at a magnetic field intensity and a frequency of stimulation.

15. The system of claim 13, wherein the controller is configured to coordinate the stimulation applied by a plurality of TMS electromagnets to apply TMS to a deep brain target.

16. The system of claim 13, wherein the patient feedback input comprises a joystick.

17. The system of claim 13, wherein the patient feedback input comprises a mouse.

18. The system of claim 13, wherein the controller is configured to limit the adjustment of the site of application of the TMS in the patient'"'"'s brain, the magnetic field intensity of the applied TMS, and the frequency of the TMS stimulation by the patient feedback input so that these parameters remain within a predetermined range of values.

19. A system for applying Transcranial Magnetic Stimulation (TMS), the system comprising:

a plurality of TMS electromagnets configured to apply TMS to a deep brain target site in a patient'"'"'s brain;

a controller configured to control the plurality of TMS electromagnets to apply TMS to the target site in the patient'"'"'s brain at a magnetic field intensity and a frequency of stimulation; and

at least one patient feedback input configured to allow the patient to adjust one or more of the site of application of the TMS in the patient'"'"'s brain, the magnetic field intensity of the applied TMS, or the frequency of the TMS stimulation during a TMS procedure on the patient.

20. The system of claim 19, wherein the patient feedback input is selected from the group consisting of a joystick, a mouse, a touch screen, and a motion sensor.