Multiplex imaging systems, devices, methods, and compositions including ferromagnetic structures
First Claim
1. A multiplex nuclear magnetic resonance imaging composition, comprisinga plurality of ferromagnetic microstructure sets,each ferromagnetic microstructure set comprising one or more ferromagnetic microstructures configured to include an accessible internal void and configured to generate a characteristic time-invariant magnetic field within the accessible internal void;
- andat least one of the ferromagnetic microstructure sets having a different characteristic time-invariant magnetic field from another of the plurality of ferromagnetic microstructure sets.
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Accused Products
Abstract
Multiplex imaging systems, devices, methods, and compositions are provided. A nuclear magnetic resonance imaging composition includes, but is not limited to, a plurality of ferromagnetic microstructures configured to generate a time-invariant magnetic field within at least a portion of one or more internal surface-defined voids.
54 Citations
20 Claims
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1. A multiplex nuclear magnetic resonance imaging composition, comprising
a plurality of ferromagnetic microstructure sets, each ferromagnetic microstructure set comprising one or more ferromagnetic microstructures configured to include an accessible internal void and configured to generate a characteristic time-invariant magnetic field within the accessible internal void; - and
at least one of the ferromagnetic microstructure sets having a different characteristic time-invariant magnetic field from another of the plurality of ferromagnetic microstructure sets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A multiplex imaging method, comprising
affecting at least one of a proton transverse magnetic relaxation time or a proton longitudinal magnetic relaxation time associated with a biological sample by providing a plurality of ferromagnetic microstructure sets, each ferromagnetic microstructure set comprising one or more ferromagnetic microstructures configured to include an accessible internal void and configured to generate a characteristic time-invariant magnetic field within the accessible internal void; - and
one or more of the ferromagnetic microstructure sets having a different characteristic time-invariant magnetic field. - View Dependent Claims (15, 16)
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17. A method of multiplex interrogation of a biological sample, comprising:
detecting nuclear magnetic resonance information generated by in vivo nuclear magnetic resonance detectable nuclei exposed to one or more internal-surface-defined voids of a plurality of different ferromagnetic microstructures configured to generate a static magnetic flux density within at least a portion of the one or more internal-surface-defined voids and configured to affect a magnetic resonance relaxation process associated with the in vivo nuclear magnetic resonance detectable nuclei while the in vivo nuclear magnetic resonance detectable nuclei are received in at least one of the one or more internal-surface-defined voids. - View Dependent Claims (18, 19, 20)
Specification