Drug Delivery Devices And Related Systems And Methods

• US 20110004143A1
• Filed: 06/30/2010
• Published: 01/06/2011
• Est. Priority Date: 07/01/2009
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Beiriger, Michael James, Kaintz, Ryan
• Granted Patent: US 8,382,696 B2
• Time in Patent Office: Days
• US Class Current: 604/6.11
• CPC Class Codes: A61G 7/0503 Holders, support devices for receptacles, e.g. for drainage or urine bags hanging-up devices for infusion A61M5/1414
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2013 having two piercing ends
• CPC Class Codes: A61J 1/2089 Containers or vials which are to be joined to each other in order to mix their contents combinations of vial and syringe for mixing their contents A61J1/2096
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61J 3/002 Compounding apparatus specially for enteral or parenteral nutritive solutions bottling liquids B67C
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3462 Circuits for the preparation thereof
• CPC Class Codes: A61M 1/3622 with a cassette forming partially or totally the blood circuit
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/36226 Constructional details of cassettes, e.g. specific details on material or shape
• CPC Class Codes: A61M 2005/3267 Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
• CPC Class Codes: A61M 2039/267 having a sealing sleeve around a tubular or solid stem portion of the connector
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/6018 providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 2205/6054 Magnetic identification systems
• CPC Class Codes: A61M 39/14 : for connecting tubes having sealed ends needle sets A61M5/162; having valves closing automatically on disconnection of line A61M39/26
• CPC Class Codes: A61M 5/14 : Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/1408 : in parallel, e.g. manifolds, sequencing valves access sites A61M39/02; tube connectors A61M39/10
• CPC Class Codes: A61M 5/1415 : Stands, brackets or the like for supporting infusion accessories
• CPC Class Codes: A61M 5/142 : Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/162 : Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14
• CPC Class Codes: A61M 5/16827 : controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/16831 : Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: A61M 5/19 : having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/36 : with means for eliminating or preventing injection or infusion of air into body dialysis systems, blood oxygenators A61M1/14; haemofiltration equipment A61M1/34; automatic tube cut-off A61M39/281
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: G16H 20/40 : relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

This disclosure relates to drug delivery devices and related systems and methods. In certain aspects, a drug delivery device includes a pump extending from a surface of the drug delivery device and a door that includes a spring-loaded member exposed along its inner surface. The fluid line can be compressed between the spring-loaded member and the pump in a manner such that the fluid line is occluded in at least one location.

Claims

1. A drug delivery device, comprising:

a pump extending from a surface of the drug delivery device; and

a door having an inner surface and comprising a spring-loaded member exposed along the inner surface, the spring-loaded member defining a recess configured to receive a portion of the pump when the door is closed,

wherein, when a fluid line is positioned in the recess and the door is closed, the fluid line is compressed between the spring-loaded member and the pump in a manner such that the fluid line is occluded in at least one location.

2. The drug delivery device of claim 1, wherein the pump is configured to pump fluid through the fluid line when the pump is operated, the fluid line is positioned in the recess, the door is closed, and the pump is operated.

3. The drug delivery device of claim 1, wherein a first spring is connected to a first end region of the spring-loaded member, and a second spring is connected to a second end region of the spring loaded member, and the first and second springs are each secured to a structure of the door.

4. The drug delivery device of claim 1, wherein the pump is rigidly fixed to a housing of the drug delivery device.

5. The drug delivery device of claim 1, wherein the pump is a peristaltic pump comprising a frame and a plurality of rollers positioned about a circumference of the frame.

6. The drug delivery device of claim 5, wherein the frame is rotatably secured to a rod that is fixed to a housing of the drug delivery device.

7. The drug delivery device of claim 5, further comprising a drive mechanism configured to operate the peristaltic pump.

8. The drug delivery device of claim 7, wherein the drive mechanism comprises a motor having an output shaft and a worm gear attached to the output shaft, and the worm gear is engaged with a gear secured to the frame such that rotation of the output shaft causes the frame of the peristaltic pump to rotate.

9. The drug delivery device of claim 1, wherein the drug delivery device comprises a plurality of pumps extending from the surface of the drug delivery device, the door comprises a plurality of spring-loaded members exposed along the inner surface, and each of the spring-loaded members defines a recess configured to receive a portion of one of the pumps when the door is closed.

10. The drug delivery device of claim 9, wherein the inner surface of the door defines a recessed region configured to receive a frame of a fluid line set therein.

11. The drug delivery device of claim 10, wherein the inner surface of the door further defines a plurality of recessed channels configured to receive fluid lines of the fluid line set therein.

12. The drug delivery device of claim 9, further comprising a plurality of air bubble detectors, each of the air bubble detectors being arranged to substantially align with a fluid line when fluid lines are positioned within the recesses of the door and the door is closed such that the air bubble detectors can detect air within the fluid lines.

13. The drug delivery device of claim 12, further comprising a plurality of drug vial holders positioned above the plurality of pumps, each of the drug vial holders being configured to retain at least one drug vial.

14. The drug delivery device of claim 13, wherein the drug delivery device is configured to operate the pumps in a manner such that, when fluid lines are positioned in the recesses of the door, the door is closed, and each of the fluid lines is in fluid communication with a drug vial retained by one of the drug vial holders, an air bubble is passed through a drug delivery line connected to each of the fluid lines between the delivery of drug from consecutive vials.

15. The drug delivery device of claim 14, wherein the drug delivery device is configured to operate the pumps in a manner to pass an air bubble through the drug delivery line after completion of the delivery of drug from each vial.

16. The drug delivery device of claim 1, wherein the drug delivery device is part of a dialysis machine.

17. The drug delivery device of claim 16, wherein the fluid line is connected to a blood circuit of the dialysis machine in a manner such that fluid is delivered through the fluid line to the blood circuit when the pump is operated.

18. A drug delivery system, comprising:

a plurality of fluid lines;

a plurality of occluders, each occluder being operably connected to one of the fluid lines; and

a single pump operably connected to a drug delivery line that is in fluid communication with each of the fluid lines,

wherein the drug delivery system is configured to operate the occluders and the pump in a manner such that, when the plurality of fluid lines are placed in fluid communication with a plurality of drug vials, drugs are drawn from the plurality of drug vials into the drug delivery line.

19. The drug delivery system of claim 18, wherein the drug delivery system is configured to operate the occluders and the pump in a manner such that drug is only drawn into the drug delivery line from one of the drug vials at a time.

20. The drug delivery system of claim 18, further comprising a plurality of air bubble detectors, each of the air bubble detectors being substantially aligned with one of the fluid lines such that the air bubble detectors can detect air within the fluid lines.

21. The drug delivery system of claim 20, wherein the drug delivery system is configured to operate the occluders and the pump in a manner such that, when the plurality of fluid lines are placed in fluid communication with a plurality of drug vials, an air bubble is passed through the drug delivery line between the delivery of drug from consecutive vials.

22. The drug delivery system of claim 21, wherein the drug delivery system is configured to operate the occluders and the pump in a manner to pass an air bubble through the drug delivery line after completion of the delivery of drug from each vial.

23. The drug delivery system of claim 18, wherein the drug delivery system is part of a dialysis machine.

24. The drug delivery system of claim 23, wherein the drug delivery line is connected to a blood circuit of the dialysis machine in a manner such that fluid can be delivered through the drug delivery line to the blood circuit when the pump is operated.

25. A drug delivery method, comprising:

passing a first drug through a drug delivery line to a vented chamber;

passing a gas bubble through the drug delivery line to the vented chamber, the gas bubble extending across substantially an entire inner diameter of the drug delivery line as the gas bubble passes therethrough; and

then

passing a second drug through the drug delivery line to the vented chamber.

26-46. -46. (canceled)

47. A drug delivery method, comprising:

determining that a first drug contained in a first container connected to a drug delivery line and a second drug contained in a second container connected to the drug delivery line are not suitable for mixing together prior to being delivered to a patient; and

after determining that the first and second drugs are not suitable for mixing, operating a drug delivery device in a manner to

deliver the first drug through the drug delivery line and to a patient;

deliver a gas bubble through the drug delivery line; and

then

deliver the second drug through the drug delivery line and to a patient.

48. (canceled)

49. A dialysis system comprising:

a dialysis machine comprising

a blood pump,

a modular drug delivery device comprising at least one drug pump and a plurality of drug vial holders, and

a housing to which the blood pump and the modular drug delivery device are secured;

a blood line set comprising multiple blood lines and a vented chamber in fluid communication with the multiple blood lines, the blood line set being connected to the blood pump in a manner such that, when the blood line set is connected to a patient and the blood pump is operated, blood of the patient is passed through the blood line set;

a drug line set comprising multiple drug lines, the drug line set being connected to the vented chamber of the blood line set and to the at least one drug pump in a manner such that, when the drug line set is fluidly connected to one or more drug vials contained in the multiple drug vial holders and the at least one drug pump is operated, drug is delivered from the one or more drug vials to the vented chamber of the blood line set via the drug line set; and

a control unit configured to operate the blood pump and the drug pump to simultaneously delivery drug and blood to the vented chamber.