BIOCOMPATIBLE SCAFFOLD FOR LIGAMENT OR TENDON REPAIR

• US 20110009963A1
• Filed: 09/21/2010
• Published: 01/13/2011
• Est. Priority Date: 10/18/2002
• Status: Active Grant

• Current Assignee: DePuy Mitek Incorporated (Johnson & Johnson)
• Original Assignee: DePuy Mitek Incorporated (Johnson & Johnson)
• Inventors: Binnette, Francois, Melican, Mora Carolynne, Zimmerman, Mark, Hwang, Julia
• Granted Patent: US 8,637,066 B2
• Time in Patent Office: Days
• US Class Current: 623/13.17
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3662 Ligaments, tendons
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment

Abstract

A biocompatible ligament repair implant or scaffold device is provided for use in repairing a variety of ligament tissue injuries. The repair procedures may be conducted with ligament repair implants that contain a biological component that assists in healing or tissue repair. The biocompatible ligament repair implants include a biocompatible scaffold and particles of viable tissue derived from ligament tissue or tendon tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.

Claims

1. A tendon or ligament repair implant, comprising:

a biocompatible scaffold having an aspect ratio greater than 1; and

at least one minced tissue particle, derived from ligament tissue or tendon tissue, that is associated with at least a portion of the scaffold.

2. The implant of claim 1, wherein the scaffold has a cylindrical shape or an elliptical shape.

3. The implant of claim 1, wherein the aspect ratio of the scaffold is in the range of about greater than 2 and less than 100.

4. The implant of claim 1, wherein the scaffold is made from a copolymer of 95:

5 lactide and glycolide.

5. The implant of claim 1, wherein the scaffold is made from polymers or copolymers formed from monomers selected from the group consisting of lactide, glycolide, dioxanone, and caprolactone.

6. The implant of claim 1, wherein the implant includes natural polymers selected from the group consisting of collagen, fibrin, and silk.

7. The implant of claim 2, wherein the implant includes strips of collagen or silk present within an inner portion of the scaffold or on a peripheral portion of the scaffold.

8. The implant of claim 1, wherein the scaffold has a diameter in the range of about 3 to 12 mm.

9. The implant of claim 1, wherein the scaffold has a tensile strength and an elastic modulus similar to that of native tendon or ligament tissue.

10. The implant of claim 9, wherein the tensile strength of the scaffold is in the range of about 1000N to 2500N.

11. The implant of claim 9, wherein the elastic modulus of the scaffold is in the range of about 150N/m to 200N/m.

12. The implant of claim 1, wherein the scaffold has a slow resorption profile.

13. The implant of claim 12, wherein the resorption profile of the scaffold spans at least three months.

14. The implant of claim 1, wherein the scaffold is formed from a foam component reinforced with a mesh component.

15. The implant of claim 14, wherein the mesh component includes polydioxanone and the foam component is a copolymer of 35:

65 ε

-caprolactone and glycolide.

16. The implant of claim 14, wherein the scaffold has an open pore structure with pores having a size sufficient to allow cell and tissue ingrowth.

17. The implant of claim 16, wherein the pores have an average diameter in the range of about 50 to 1000 microns.

18. The implant of claim 14, wherein the foam component has a thickness in the range of about 300 microns to 2 mm.

19. The implant of claim 14, wherein the mesh component has a mesh density in the range of about 12% to 80%.

20. The implant of claim 1, wherein the scaffold is formed of plurality of filaments.