ADHESIVE ARTICLES

• US 20110021965A1
• Filed: 11/19/2008
• Published: 01/27/2011
• Est. Priority Date: 11/19/2007
• Status: Active Grant

• Current Assignee: Charles Stark Draper Laboratory Incorporated, Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Karp, Jeffrey, Borenstein, Jeffrey, Carter, David, Alborz, Mahdavi, Langer, Robert, Zumbuehl, Andreas, Bettinger, Christopher, Ferreira, Lino, Chan, Edwin
• Granted Patent: US 9,060,842 B2
• Time in Patent Office: Days
• US Class Current: 602/54
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2013/00774 arranged in discrete dots
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 31/005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: B29C 65/18 using heated tools
• CPC Class Codes: B29C 65/52 characterised by the way of applying the adhesive B29C65/50 takes precedence; apparatus for applying liquids in general B05C; processes for applying liquids in general B05D
• CPC Class Codes: B29C 66/1122 Single lap to lap joints, i.e. overlap joints B29C66/45, B29C66/472, B29C66/52272 take precedence
• CPC Class Codes: B31B 2160/10 rectangular and flat, i.e. without structural provision for thickness of contents
• CPC Class Codes: B31B 70/81 Forming or attaching accessories, e.g. opening devices, closures or tear strings
• CPC Class Codes: C04B 37/005 consisting of glass or ceramic material

Abstract

An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.

Claims

1-137. -137. (canceled)

138. An adhesive article comprising:

a substrate wherein protrusions extend from a surface of the substrate, the surface having a surface modification to enhance bonding with a biological tissue;

wherein the modification and protrusions together impart adhesiveness to the article without conferring inflammatory properties such that the article is biocompatible.

139. The adhesive article of claim 138, wherein at least a portion of the adhesive article has a wet adhesive strength that is greater than or substantially equal to a dry adhesive strength.

140. The adhesive article of claim 138, wherein the article is at least partially biodegradable.

141. The adhesive article of claim 138, wherein the article is biocompatible in that, when the article is implanted in a rat, the tissue response to the article after 7 days is no greater than mild.

142. The adhesive article of claim 138, wherein the article is biocompatible in that, when the article is implanted in a rat, after 7 days, no giant cell reaction is observed.

143. The adhesive article of claim 138, wherein the article is biocompatible in that, when the article is implanted in rat no distinctive papillary architecture is observed in cellular infiltrate after 7 days.

144. The adhesive article of claim 138, wherein the article is biocompatible in that its addition to cells in vitro results in less than or equal to about 50% cell death, or less than or equal to about 45% cell death, or less than or equal to about 40% cell death, or less than or equal to about 35% cell death, or less than or equal to about 30% cell death, or less than or equal to about 25% cell death, or less than or equal to about 20% cell death, or less than or equal to about 15% cell death, or less than or equal to about 10% cell death, or less than or equal to about 5% cell death, or less than about 5% cell death.

145. The adhesive article of claim 138, wherein the protrusions have an average height of less than approximately 1,000 micrometers.

146. The adhesive article of claim 138, wherein the protrusions have an average tip width of from approximately 0.05 μ

m to approximately 10 μ

m.

147. The adhesive article of claim 138, wherein the protrusions have an average base width of from approximately 0.05 μ

m to approximately 10 μ

m.

148. The adhesive article of claim 138, wherein the protrusions have an average center-to-center pitch of from approximately 0.2 μ

m to approximately 500 μ

m.

149. The adhesive article of claim 138, wherein at least a portion of the adhesive article has an adhesive strength of greater than approximately 0.1 Newton per square centimeter of projected area when measured according to ASTM standard D4501.

150. The adhesive article of claim 138, wherein the article comprises a biomolecule or a pharmaceutical compound.

151. The adhesive article of claim 138, wherein the adhesive article has maximum elongation greater than approximately 20%.

152. The adhesive article of claim 138, wherein at least a portion of the adhesive article has a porosity of greater than approximately 10%.

153. The adhesive article of claim 138, wherein at least a portion of the adhesive article comprises a plurality of cells.

154. The adhesive article of claim 138, in the form of a tape.

155. An adhesive article comprising:

a substrate wherein protrusions extend from a surface of the substrate, the surface having a surface modification;

wherein the modification and protrusions together impart adhesiveness to the article and wherein at least a portion of the adhesive article has a wet adhesive strength that is greater than or substantially equal to a dry adhesive strength.

156. A method, comprising a step of:

contacting an adhesive article to a biological tissue, the adhesive article comprising a substrate wherein protrusions extend from a surface of the substrate, the surface having a surface modification to enhance bonding with the biological tissue;

wherein the modification and protrusions together impart adhesiveness to the article without conferring inflammatory properties such that the article is biocompatible.

157. The method of claim 156 further comprising a step of mechanically interlocking the adhesive article with the biological tissue.

158. A method, comprising a step of:

providing an adhesive article, the adhesive article comprising a substrate wherein protrusions extend from a surface of the substrate,

modifying the surface to enhance bonding with a biological tissue;

wherein the step of modifying and the protrusions together impart adhesiveness to the article without conferring inflammatory properties such that the article is biocompatible.