REFLECTANCE CALIBRATION OF FLUORESCENCE-BASED GLUCOSE MEASUREMENTS
First Claim
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1. A method of measuring a glucose level comprising:
- emitting a first excitation wavelength;
measuring a first fluorescence intensity;
measuring a first reflectance intensity;
calibrating said first fluorescence intensity measurement with said first reflectance intensity measurement; and
calculating a glucose level with said calibrated first fluorescence intensity measurement.
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Abstract
A noninvasive or minimally invasive procedure and system for measuring blood glucose levels is disclosed. A set of photodiodes detects the fluorescence and reflectance of light energy emitted from one or more emitters, such as LEDs, into a patient'"'"'s skin. In an embodiment, small molecule metabolite reporters (SMMRs) that bind to glucose are introduced to the measurement area to provide more easily detected fluorescence.
345 Citations
24 Claims
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1. A method of measuring a glucose level comprising:
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emitting a first excitation wavelength; measuring a first fluorescence intensity; measuring a first reflectance intensity; calibrating said first fluorescence intensity measurement with said first reflectance intensity measurement; and calculating a glucose level with said calibrated first fluorescence intensity measurement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An apparatus for measuring a glucose level comprising:
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an excitation module that emits an excitation signal adapted to activate a fluorophore in skin; a reflectance measurement module that measures the intensity of one or more wavelengths reflected by said skin from said excitation module; a fluorescence measurement module that measures the intensity of one or more wavelengths emitted by said fluorophore; a glucose calculation module that accepts reflectance intensity data from said reflectance measurement module and fluorescence intensity data from said fluorescence measurement module, wherein said glucose calculation module calculates an in vivo glucose level from said reflectance intensity data and said fluorescence intensity data; a system controller that accepts said in vivo glucose level from said glucose calculation module; and a display adapted to convey said glucose level to a user. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification