CREATINE ORAL SUPPLEMENTATION USING CREATINE HYDROCHLORIDE SALT

• US 20110034421A1
• Filed: 10/21/2010
• Published: 02/10/2011
• Est. Priority Date: 05/15/2003
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Nebraska, Vireo Systems Incorporated
• Original Assignee: Vireo Systems Incorporated
• Inventors: Faulkner, Mark C., Vennerstrom, Jonathan L., Miller, Donald W.
• Granted Patent: US 8,354,450 B2
• Time in Patent Office: Days
• US Class Current: 514/118
• CPC Class Codes: A23K 20/10 Organic substances
• CPC Class Codes: A23K 20/105 Aliphatic or alicyclic compounds
• CPC Class Codes: A23K 20/142 Amino acids; Derivatives thereof
• CPC Class Codes: A23K 50/10 for ruminants
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23P 10/40 free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added A23P10/20, A23P10/30 take precedence
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/316 having an effect on regeneration or building of ligaments or muscles
• CPC Class Codes: A23V 2200/33 High-energy foods and drinks, sports drinks
• CPC Class Codes: A23V 2250/306 Creatine
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/661 Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26

Abstract

The present invention is directed to a third generation form of creatine, specifically a creatine hydrochloride salt, that drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

Claims

1. A supplement comprising:

creatine HCl, wherein the creatine HCl possesses a solubility of at least 600 mg/mL in water at 25°

C.

2. The supplement of claim 1, wherein the creatine HCl is at least 95 percent free of contaminants.

3. The supplement of claim 1, wherein the recommended dosage range for the creatine HCl is between about one quarter teaspoon to about one tablespoon per hundred pounds body weight.

4. The supplement of claim 1, wherein the supplement is capable of being taken orally.

5. The supplement of claim 1, wherein the creatine HCl has a shelf-life of at least about 45 days in aqueous solution at room temperature.

6. The supplement of claim 4, wherein an effective dosage of the supplement is about 500 mg to about 1500 mg of creatine HCl per 100 pounds body weight.

7. The supplement of claim 1, wherein the creatine HCl further comprises an additive or feed supplement for livestock.

8. A formula used to enhance athletic performance comprising:

creatine HCl, wherein the creatine HCl exhibits an aqueous solubility that is at least about 15 times greater than that of creatine monohydrate.

9. The formula of claim 8, further comprising:

at least one additional species of creatine selected from the group comprising creatine esters, creatine pyruvate, creatine phosphate, creatine alpha-ketoglutarate, creatine citrate, and combinations thereof.

10. The formula of claim 8, further comprising:

at least one additional supplement selected from the group comprising carbonate salts, methylsulfonylmethane, glucosamine, and chondroitin.

11. The formula of claim 8, further comprising:

at least one compound selected from the group comprising proteins, amino acid supplements, carbohydrates, D-Ribose, fats, fiber and combinations thereof.

12. The formula of claim 8, further comprising:

at least one sweetener selected from the group comprising sucralose, aspartame, saccharin, acesulfame potassium, neohesperidin dihydrochalcone, glycyrrhizin, thaumatin, alitame, stevioside, and combinations thereof.

13. The formula of claim 8, wherein the formula further comprises a supplement selected from the group comprising sports bars, nutritional bars, powders, liquids, gels, sports drinks, and beverages.

14. The formula of claim 8, further comprising:

at least one flavoring agent selected from the group comprising cocoa, yogurt, peanut butter, mint, cheesecake, hazelnut paste, almonds, granola, coconut, strawberry, banana, cherry, plum, raspberry, lemon, orange, lime, pineapple, blueberry and other fruit flavors, coffee, or cremes and jellies, and combinations thereof.

15. A granular powder comprising:

a creatine HCl product formed by the reaction of an alcohol, an acid catalyst, and creatine monohydrate, wherein the solubility of the creatine HCl product is at least about 650 mg/ml.

16. The granular powder of claim 15, wherein the alcohol is selected from the group consisting of ethanol, methanol, butanol, and isopropanol.

17. The granular powder of claim 15, wherein the reaction is a super-saturated reaction comprising ethanol, acetyl chloride, and creatine monohydrate.

18. The granular powder of claim 17, wherein the volume of ethanol used is between about 4 and 5 L per kg of creatine monohydrate, and wherein the quantity of acetyl chloride used is between about 1.0 to about 1.1 mole equivalents of creatine monohydrate.

19. The granular powder of claim 17, wherein the super-saturated reaction further comprises the steps of:

mixing the ethanol and acetyl chloride in a reactor that is cooled to between about 0°

C. and 20°

C.;

allowing the temperature of the reactor to increase to about 38°

C.;

adding creatine monohydrate; and

maintaining a temperature of between about 30°

C. and about 40°

C.

20. The granular powder of claim 15, wherein the creatine HCl product is at least 95 percent free of contaminants.