BICYCLIC CYCLOHEXITOL NUCLEIC ACID ANALOGS
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Abstract
The present disclosure provides bicyclic cyclohexitol nucleoside analogs of formula I and oligomeric compounds comprising these nucleoside analogs. These bicyclic nucleoside analogs are expected to be useful for enhancing properties of oligomeric compounds including for example nuclease resistance.
102 Citations
46 Claims
- 1. A bicyclic nucleoside analog having formula I:
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25. A bicyclic nucleoside analog comprising a 6 membered ring having 5 carbon atoms and one heteroatom selected from oxygen, sulfur or substituted nitrogen, wherein:
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one of the carbon atoms flanking the heteroatom is substituted with a first group that can form an internucleoside linkage and the carbon atom adjacent to the other flanking carbon atom is substituted with a nucleobase; one additional ring carbon is substituted with a second group that can form an internucleoside linkage; and wherein said 6 membered ring further comprises a bridge connecting two ring carbon atoms wherein the two ring carbon atoms are separated by at least one additional ring carbon atom. - View Dependent Claims (26, 27, 28)
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- 29. An oligomeric compound comprising at least one bicyclic nucleoside analog having formula III:
Specification