Extracranial implantable devices, systems and methods for the treatment of neuropsychiatric disorders
First Claim
1. A system for trigeminal nerve stimulation for treatment of a neuropsychiatric disorder, the system comprising:
- a pulse generator; and
a subcutaneous electrode assembly in electrical communication with the pulse generator, the assembly comprising;
a first electrode comprising at least one contact configured for subcutaneous placement at a first region of the patient'"'"'s face,wherein the first electrode is configured to be implanted in proximity to, adjacent to or in contact with at least one branch of the trigeminal nerve for treatment of a neuropsychiatric disorder by trigeminal nerve stimulation,wherein the system is configured for minimal current penetration into a brain of a patient, andwherein the at least one branch of the trigeminal nerve is selected from the group consisting of;
ophthalmic nerve, infraorbital nerve, mentalis nerve, supratrochlear nerve, infratrochlear nerve, zygomaticotemporal nerve, zygomaticofacial nerve, zygomaticoorbital nerve, nasal nerve, and auriculotemporal nerve.
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Accused Products
Abstract
The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.
136 Citations
20 Claims
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1. A system for trigeminal nerve stimulation for treatment of a neuropsychiatric disorder, the system comprising:
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a pulse generator; and a subcutaneous electrode assembly in electrical communication with the pulse generator, the assembly comprising; a first electrode comprising at least one contact configured for subcutaneous placement at a first region of the patient'"'"'s face, wherein the first electrode is configured to be implanted in proximity to, adjacent to or in contact with at least one branch of the trigeminal nerve for treatment of a neuropsychiatric disorder by trigeminal nerve stimulation, wherein the system is configured for minimal current penetration into a brain of a patient, and wherein the at least one branch of the trigeminal nerve is selected from the group consisting of;
ophthalmic nerve, infraorbital nerve, mentalis nerve, supratrochlear nerve, infratrochlear nerve, zygomaticotemporal nerve, zygomaticofacial nerve, zygomaticoorbital nerve, nasal nerve, and auriculotemporal nerve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 19, 20)
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9. A subcutaneous electrode assembly for trigeminal nerve stimulation for treatment of a neuropsychiatric disorder, the assembly comprising:
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a first electrode comprising at least one contact configured for subcutaneous placement at a first region of the patient'"'"'s face, wherein the first electrode is configured to be implanted in proximity to, adjacent to or in contact with at least one branch of the trigeminal nerve for treatment of a neuropsychiatric disorder by trigeminal nerve stimulation, wherein the assembly is configured for minimal current penetration into a brain of a patient, and wherein the at least one branch of the trigeminal nerve is selected from the group consisting of;
ophthalmic nerve, infraorbital nerve, mentalis nerve, supratrochlear nerve, infratrochlear nerve, zygomaticotemporal nerve, zygomaticofacial nerve, zygomaticoorbital nerve, nasal nerve, and auriculotemporal nerve. - View Dependent Claims (10, 11, 12, 13)
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14. A method for treating a neuropsychiatric disorder by trigeminal nerve stimulation, comprising:
implanting an electrode assembly in a patient, the subcutaneous electrode assembly comprising; a first electrode comprising at least one contact configured for subcutaneous placement at a first region of the patient'"'"'s face, wherein the first electrode is configured to be implanted in proximity to, adjacent to or in contact with at least one branch of the trigeminal nerve for treatment of a neuropsychiatric disorder by trigeminal nerve stimulation, wherein the assembly is configured for minimal current penetration into a brain of a patient, and wherein the at least one branch of the trigeminal nerve is selected from the group consisting of;
ophthalmic nerve, infraorbital nerve, mentalis nerve, supratrochlear nerve, infratrochlear nerve, zygomaticotemporal nerve, zygomaticofacial nerve, zygomaticoorbital nerve, nasal nerve, and auriculotemporal nerve; andapplying electrical signals to the electrode assembly at specified operational parameters to treat a neuropsychiatric disorder. - View Dependent Claims (15, 16, 17, 18)
Specification