Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject

• US 20110118697A1
• Filed: 02/19/2010
• Published: 05/19/2011
• Est. Priority Date: 11/13/2009
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Ishikawa, Muriel Y., Eckhoff, Philip A., Wood, Lowell L. JR., Rivet, Dennis J., Hyde, Roderick A., Kare, Jordin T., Sweeney, Elizabeth A., Wood, Victoria Y.H., Leuthardt, Eric C.
• Granted Patent: US 8,419,707 B2
• Time in Patent Office: Days
• US Class Current: 604/502
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/112 Gait analysis
• CPC Class Codes: A61B 5/1126 using a particular sensing technique
• CPC Class Codes: A61B 5/4528 Joints A61B5/4533, A61B5/4538 take precedence
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61M 2005/3022 Worn on the body, e.g. as patches pressure infusion of the skin patch type A61M5/14248
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Claims

1-51. -51. (canceled)

52. A method comprising:

injecting one or more medicaments to one or more joint tissues of a mammalian subject, wherein the injecting of the one or more medicaments is via a device including one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject;

one or more sensors configured to detect one or more physiological conditions of the one or more joints; and

one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

53. The method of claim 52, wherein the one or more applicators include one or more high speed microjets.

54. The method of claim 53, wherein the high speed microjets are nanoliter-volume pulsed microjets.

55. The method of claim 52, wherein the one or more substrates includes one or more patches or one or more sheaths.

56. The method of claim 55, wherein the one or more sheaths includes a sleeve-shaped article of clothing or a sleeve-shaped body covering.

57. The method of claim 56, wherein the one or more sheaths includes shirt sleeve, pant, leg covering, glove, stocking, bandage-like covering, brace, knee brace, elbow brace, ankle brace, foot brace, hand brace, or spinal brace.

58. The method of claim 57, wherein the one or more substrates is attached to the one or more body contours by glue, suction, suture, or hook.

59. The method of claim 52, wherein the one or more joint tissues includes one or more of a fibrous capsule, subsynovium, synovial membrane, synovium, joint cavity, synovial fluid, articular cartilage, subchondral bone, or ligament.

60. The method of claim 52, wherein the one or more joints includes a synovial joint, cartilaginous joint, or fibrous joint.

61. The method of claim 52, wherein the one or more applicators supported by the one or more substrates are configured to respond to the one or more sensors, wherein the one or more applicators are configured to inject the one or more medicaments to the one or more joint tissues of the mammalian subject.

62. The method of claim 52, further including providing one or more sensors configured to detect movement of the one or more body contours.

63. The method of claim 62, wherein the one or more sensors are configured to monitor joint movement, body movement, or gait of the mammalian subject.

64. The method of claim 62, wherein the one or more sensors are configured to monitor posture of the mammalian subject.

65. The method of claim 52, wherein the one or more sensors are configured to detect tissue swelling, tissue pressure, tissue color, tissue temperature, environmental temperature, electrical property of tissue, optical property of tissue, perspiration, or presence of an analyte.

66. The method of claim 65, wherein the analyte includes an inflammatory marker, antibody, or cytokine.

67. The method of claim 52, further including providing one or more sensors configured to determine quality of location or quality of contact placement of the one or more sheaths on the one or more body contours.

68. The method of claim 52, further including providing a controller configured to control release of the one or more medicaments from the one or more applicators.

69. The method of claim 68, wherein the controller is configured to control a timed-release dosage of the one or more medicaments.

70. The method of claim 68, wherein the controller is configured to report quantity and frequency of dosage of the one or more medicaments.

71. The method of claim 68, wherein the controller is configured to control a maximum dosage of the one or more medicaments for a time period.

72. The method of claim 68, further including providing one or more sensors, wherein the controller is configured to respond to the one or more sensors.

73. The method of claim 72, wherein the one or more sensors are configured to detect one or more conditions at one or more of the one or more joints and the controller is configured to control release of the one or more medicaments at others of the one or more joints of the mammalian subject.

74. The method of claim 73, wherein the one or more sensors are configured to detect one or more physiological conditions of the mammalian subject.

75. The method of claim 73, wherein the one or more sensors are configured to detect movement of the one or more body contours.

76. The method of claim 52, wherein the one or more applicators further include tissue permeabilization components including one or more of electronics, ultrasonics, chemical permeation enhancer, iontophoresis, microdialysis, ultrafiltration, electromagnetic, electroosmosis, sonophoresis, microdialysis, suction, electroporation, thermal poration, microporation, heating component, or laser.

77. The method of claim 52, wherein the one or more sheaths includes a tourniquet configured to apply intermittent pressure in the region of the jointed area.

78. The method of claim 77, wherein the tourniquet is configured to apply a constricting force thereby causing the one or more applicators to penetrate the stratum corneum of the skin of the mammalian subject.

79. The method of claim 52, further including providing a component for transient mechanical/electrical acceleration of the one or more medicaments from the high speed microjets.

80. The method of claim 79, wherein the component for transient mechanical/electrical acceleration includes a fluid displacement actuator configured as one or more piezoelectric actuators, one or more springs, one or more solenoids, one or more magnets, one or more motors, or one or more compressed gas actuators.

81. The method of claim 79, wherein the component for mechanical/electrical acceleration applies concentration gradients of the one or more medicaments in a time-dependent manner.

82. The method of claim 52, wherein the one or more medicaments includes steroids, corticosteroids, analgesics, COX-2 inhibitors, or NSAID.

83. The method of claim 52, further including providing a pharmaceutical composition including the one or more medicaments in a thixotropic medium.

84. The method of claim 52, wherein the one or more applicators are configured to apply the one or more medicaments in a time-dependent manner.

85. The method of claim 84, wherein the one or more applicators are configured to apply the one or more medicaments in concentration gradients in the time-dependent manner.

86. The method of claim 84, wherein the one or more medicaments is configured to have a short effective half-life.

87. The method of claim 84, wherein the one or more medicaments is configured to have a long effective half-life.

88-139. -139. (canceled)