Residual-Based Monitoring of Human Health
First Claim
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1. A system for monitoring the health status of a human, comprising:
- an ambulatory device disposed to receive multiple biological parameters from a plurality of sensors attached to a monitored human;
a computer disposed to obtain monitored observations of multiple biological parameters from said ambulatory device; and
a computer-accessible memory for storing a set of exemplary observations of said multiple biological parameters characteristic of the behavior of said multiple biological parameters under normal health conditions for the monitored human;
said computer being specially configured to generate an estimate of at least one of said multiple biological parameters in a monitored observation obtained from said ambulatory device, as a linear combination of at least some of said set of exemplary observations, determined from a kernel-based comparison of the monitored observation and at least some exemplary observations; and
said computer being further specially configured to compare said estimate to the corresponding value of the at least one of said multiple biological parameters in said monitored observation, to generate a residual, and make a determination of the health status of the human there from.
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Abstract
Improved human health monitoring is provided in the context of sensor measurements of typical vital signs and other biological parameters, by a system and method using an empirical model of the parameters and disposed to estimate values of the parameters in response to actual measurements. Residuals resulting from the difference between the estimates and actual measurements are analyzed for robust indications of incipient health issues. Residual analysis is both more robust and more sensitive than conventional univariate range checking on vital signs.
86 Citations
81 Claims
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1. A system for monitoring the health status of a human, comprising:
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an ambulatory device disposed to receive multiple biological parameters from a plurality of sensors attached to a monitored human; a computer disposed to obtain monitored observations of multiple biological parameters from said ambulatory device; and a computer-accessible memory for storing a set of exemplary observations of said multiple biological parameters characteristic of the behavior of said multiple biological parameters under normal health conditions for the monitored human; said computer being specially configured to generate an estimate of at least one of said multiple biological parameters in a monitored observation obtained from said ambulatory device, as a linear combination of at least some of said set of exemplary observations, determined from a kernel-based comparison of the monitored observation and at least some exemplary observations; and said computer being further specially configured to compare said estimate to the corresponding value of the at least one of said multiple biological parameters in said monitored observation, to generate a residual, and make a determination of the health status of the human there from. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A system for monitoring the health status of a ventilated patient comprising:
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a ventilator for providing respiratory support of the patient, further disposed to provide computerized readings of a plurality of ventilation-related parameters; a computer disposed to obtain monitored observations of multiple physiological parameters of said patient, inclusive of at least one of said plurality of ventilation-related parameters from said ventilator; and a computer-accessible memory for storing a set of exemplary observations of said multiple physiological parameters characteristic of the behavior of said multiple physiological parameters under known health conditions; said computer being specially configured to generate an estimate of at least one of said multiple physiological parameters in a monitored observation, as a linear combination of at least some of said set of exemplary observations, determined from a kernel-based comparison of the monitored observation and at least some exemplary observations; and said computer being further specially configured to compare said estimate to the corresponding value of the at least one of said multiple physiological parameters in said monitored observation, to generate a residual, and make a determination of the health status of the patient there from. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. A computerized system for monitoring the health status of a human, comprising:
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a data feed for providing monitored observations of multiple vital signs from the monitored human, a vital sign being a direct sensor measurement of a biological signal or a computational transformation thereof; a computing platform comprising at least one networked computer, said platform disposed to obtain monitored observations of the multiple vital signs from said data feed; a computer-accessible memory for storing a set of exemplary observations of said multiple vital signs characteristic of the behavior of said multiple vital signs under normal health conditions for the monitored human; said computing platform being specially configured to test whether monitored observations from the data feed are characteristic of at least one activity state, and filtering out observations that are not; said computing platform being specially configured to generate an estimate of at least one of said multiple vital signs in a monitored observation obtained from said data feed, as a linear combination of at least some of said set of exemplary observations, determined from a kernel-based comparison of the monitored observation and at least some exemplary observations; and said computing platform being further specially configured to compare said estimate to the corresponding value of the at least one of said multiple vital signs in said monitored observation, to generate a residual, and make a determination of the health status of the human there from. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81)
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Specification