IN VIVO COMPONENT MEASUREMENT METHOD, DATA PROCESSING METHOD FOR IN VIVO COMPONENT MEASUREMENT, IN VIVO COMPONENT MEASUREMENT APPARATUS AND COLLECTION MEMBER

• US 20110124998A1
• Filed: 01/28/2011
• Published: 05/26/2011
• Est. Priority Date: 07/31/2008
• Status: Active Grant

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Okada, Seiki
• Granted Patent: US 8,747,316 B2
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 2562/0295 Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157 disposable multilayered or laminated electrodes G01N27/307; details of handling chemical test elements G01N33/4875
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

An in vivo component measurement method allowing how long a high concentration state of a measurement target component continues in an organism to be grasped is provided. In this in vivo component measurement method, a value relating to an amount of a measurement target component in tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made is acquired.

Claims

1. An in vivo component measurement method, comprising:

preparing tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made; and

acquiring a value relating to an amount of a measurement target component in extracted said tissue fluid.

2. The in vivo component measurement method according to claim 1, wherein

said treatment is made by forming fine pores on a skin of the organism, and

said extraction is performed through said skin where said fine pores are formed.

3. The in vivo component measurement method according to claim 1, wherein

said extraction is performed by extracting tissue fluid to an extraction medium containing a hypertonic aqueous solution having a higher osmotic pressure than pure water.

4. The in vivo component measurement method according to claim 3, wherein

said hypertonic aqueous solution contains an auxiliary component different from said measurement target component, the auxiliary component being contained with said measurement target component in said tissue fluid.

5. The in vivo component measurement method according to claim 4, wherein

said auxiliary component is at least one selected from a group consisting of kalium chloride, glycine and urea.

6. The in vivo component measurement method according to claim 5, wherein

a concentration of said auxiliary component in said hypertonic aqueous solution is 0.2 mmol/L or more.

7. The in vivo component measurement method according to claim 1, wherein

a time for extracting said tissue fluid is 120 minutes or more.

8. The in vivo component measurement method according to claim 1, wherein

said time for extracting said tissue fluid is 180 minutes or more.

9. The in vivo component measurement method according to claim 1, wherein

said measurement target component is glucose.

10. The in vivo component measurement method according to claim 1, further comprising acquiring an integrated value of a concentration of the measurement target component in an organism, corresponding to an extraction time of tissue fluid based on said value relating to the amount of the measurement target component.

11. The in vivo component measurement method according to claim 10, further comprising acquiring an amount of an electrolyte contained in extracted tissue fluid, wherein

said integrated value is acquired based on said value relating to the amount of the measurement target component and the amount of the electrolyte.

12. The in vivo component measurement method according to claim 10, wherein

said integrated value is a value corresponding to an area under the curve (AUC) of a blood concentration time curve of said measurement target component.

13. The in vivo component measurement method according to claim 12, further comprising acquiring a value obtained by dividing said value corresponding to an AUC of said measurement target component by a time for extraction.

14. The in vivo component measurement method according to claim 1, further comprising informing a subject of an end of extraction when a prescribed time of 60 minutes or more elapses from a start of extraction of said tissue fluid.

15. An in vivo component measurement apparatus, comprising:

a set portion for setting a collection member capable of accumulating a measurement target component in tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made; and

a detection portion for acquiring a value relating to an amount of said measurement target component accumulated by said collection member set on said set portion.

16. The in vivo component measurement apparatus according to claim 15, further comprising an analysis portion acquiring an integrated value of a concentration of said measurement target component in said organism, corresponding to an extraction time of tissue fluid based on said value relating to an amount of said measurement target component.

17. A collection member, used in an in vivo component measurement apparatus for extracting tissue fluid from an organism on which extraction of tissue fluid has been enhanced and acquiring a value relating to an amount of a measurement target component in extracted tissue fluid, including an extraction medium capable of accumulating said measurement target component in tissue fluid extracted for 60 minutes or more from said organism.

18. The collection member according to claim 17, wherein

said extraction medium is a gel.

19. The collection member according to claim 18, wherein

said gel contains a hypertonic aqueous solution having a higher osmotic pressure than pure water.

20. The collection member according to claim 19, wherein

said hypertonic aqueous solution contains an auxiliary component other than said measurement target component, contained with said measurement target component in said tissue fluid.

21. The collection member according to claim 20, wherein

said auxiliary component is at least one selected from a group consisting of kalium chloride, glycine and urea.

22. The collection member according to claim 21, wherein

a concentration of said auxiliary component in said hypertonic aqueous solution is 0.2 mmol/L or more.

23. An in vivo component measurement method, comprising:

accumulating a measurement target component in tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made with converting the measurement target component into a component for accumulation different from said measurement target component; and

acquiring a value relating to an amount of said measurement target component based on an amount of accumulated said component for accumulation.

24. A data processing method for in vivo component measurement, comprising:

acquiring a value relating to an amount of a measurement target component in tissue fluid extracted for 60 minutes or more from an organism on which a treatment for enhancing extraction of tissue fluid has been made; and

acquiring an integrated value of the measurement target component concentration in an organism, corresponding to an extraction time based on acquired said value.