EXPERT SYSTEM AND METHOD

• US 20110137368A1
• Filed: 02/15/2011
• Published: 06/09/2011
• Est. Priority Date: 12/26/2000
• Status: Active Grant

• Current Assignee: James Kalgren, Jeffrey E. Stahmann, Par Lindh, Rene H. Wentkowski
• Original Assignee: James Kalgren, Jeffrey E. Stahmann, Par Lindh, Rene H. Wentkowski
• Inventors: Lindh, Par, Stahmann, Jeffrey E., Kalgren, James, Wentkowski, Rene H.
• Granted Patent: US 8,099,165 B2
• Time in Patent Office: Days
• US Class Current: 607/25
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

A medical device programmer and a method of operation in which a first data value is received and used in the execution of one or more algorithms. One or more suggested pulse generator settings are calculated from the one or more algorithms based on the first data value, and the one or more suggested pulse generator settings are displayed on an interactive display screen of the medical device programmer. In one embodiment, the first data value is a duration interval of a QRS complex. From the duration interval, suggestions are made as to one or more ventricular chambers in which to provide pacing pulses. Additionally, pacing intervals for an AV delay are suggested based on measured P-R intervals, or pacing intervals for an LV offset are suggested based on a measured duration interval of a V-V-interval between a right ventricular event and a left ventricular event.

Claims

1. An external medical device to communicate with an implantable device, the external device comprising:

a user interface configured to receive a prompt to generate one or more therapy settings for the implantable device;

a pacing site selector configured to;

receive a measure of a QRS complex duration into pacing site selector input;

measure a time of occurrence of a peak of depolarization of a right ventricle (RV) and a time of peak of occurrence of depolarization of a left ventricle (LV);

determine, as a first generated therapy setting, a pacing site according to the measure of QRS complex duration and the time relationship of the depolarization peak of the RV and the depolarization peak of the LV; and

provide the determined pacing site to at least one of a user or process.

2. The external medical device of claim 1, wherein the pacing site selector is configured to:

select a pacing site in the RV when the measured QRS complex duration exceeds a specified duration threshold and the difference between the time of occurrence of the depolarization peak of the LV and the time of occurrence of the depolarization peak of the RV is less than or equal to zero; and

select a pacing site in the LV when the measured QRS complex duration exceeds a specified duration threshold and the difference between the time of occurrence of the depolarization peak of the LV and the time of occurrence of the depolarization peak of the RV is less than or equal to zero.

3. The external medical device of claim 1,

wherein the external device includes a receiver/transmitter communicatively coupled to the pacing site selector input, and

wherein the pacing site selector is configured to:

initiate a communication of a request to the implantable device in response to the user prompt;

receive a representation of a sensed RV cardiac signal sensed and a representation of a sensed LV cardiac signal in response to the communicated request;

measure the QRS complex duration using at least one of cardiac signals;

measure the time of occurrence of a peak of depolarization of the RV using the RV cardiac signal; and

measure the time of occurrence of a peak of depolarization of the LV using the LV cardiac signal.

4. The external medical device of claim 1, including an LV offset determiner configured to:

measure, in response to the prompt received via the user interface, a duration interval between a cardiac event in the RV and a cardiac event in the LV; and

calculate, as a second generated therapy setting, an LV offset interval using the measured duration interval.

5. The external medical device of claim 4, including:

a receiver/transmitter communicatively coupled to the LV Offset determiner, and

wherein the LV Offset determiner is configured to;

initiate communication of a request to the implantable device in response to the user prompt;

receive a representation of a sensed RV cardiac signal sensed and a representation of a sensed LV cardiac signal in response to the communicated request; and

measure the duration interval using the received representations of the sensed cardiac signals.

6. The external medical device of claim 4, wherein LV Offset determiner is configured to:

calculate the LV offset interval using a first set of calculation coefficients when the measured time duration ends with an intrinsic cardiac event; and

calculate the LV offset interval using a second set of calculation coefficients when the measured time duration ends with a paced cardiac event.

7. The external medical device of claim 4, wherein LV Offset determiner is configured to:

determine a frequency with which pacing therapy is delivered by the implantable device;

compare the determined frequency of pacing to a specified pacing frequency value; and

adjust calculation coefficients used to calculate the LV offset interval according to the comparison.

8. The external medical device of claim 1, including a PR delay determiner configured to:

measure, in response to the prompt received via the user interface, a time interval between a cardiac event in an atrium and a cardiac event in the ventricle; and

calculate, as a second generated therapy setting, an AV delay interval using the measured time interval.

9. The external medical device of claim 8, wherein the PR delay determiner is configured to:

initiate a communication of a request to the implantable device in response to the user prompt;

receive a representation of a cardiac signal sensed in an atrium and a representation of a cardiac signal sensed in a ventricle in response to the communicated request; and

measure the time interval using the received representations of the sensed cardiac signals.

10. The external medical device of claim 8, wherein the PR delay determiner is configured to:

calculate the AV delay interval using a first set of calculation coefficients when the measured time interval ends with an intrinsic ventricular event; and

calculate the AV delay interval using a second set of calculation coefficients when the measured time interval ends with a paced ventricular event.

11. The external medical device of claim 8, wherein the PR delay determiner is configured to:

determine a frequency with which intrinsic ventricular events are sensed by the implantable device;

compare the frequency of intrinsic ventricular events to a specified sensed event frequency value; and

adjust calculation coefficients used to calculate the AV delay interval according to the comparison.

12. A method of operating an external device, wherein the external device is capable of communicating with an implantable device, the method comprising:

receiving a prompt via a user interface of the external device to generate one or more therapy settings for the implantable device;

receiving a measure of a QRS complex duration into the external device;

measuring, with the external device, a time of occurrence of a peak of depolarization of a right ventricle (RV) and a time of peak of occurrence of depolarization of a left ventricle (LV); and

determining with the external device, as a first generated therapy setting, a pacing site according to the measure of QRS complex duration and the time relationship of the depolarization peak of the RV and the depolarization peak of the LV, and wherein the external device provides the determined pacing site to at least one of a user or process.

13. The method of claim 12, wherein determining a pacing site includes:

selecting a pacing site in the RV when the measured QRS complex duration exceeds a specified duration threshold and the difference between the time of occurrence of the depolarization peak of the LV and the time of occurrence of the depolarization peak of the RV is less than or equal to zero; and

selecting a pacing site in the LV when the measured QRS complex duration exceeds a specified duration threshold and the difference between the time of occurrence of the depolarization peak of the LV and the time of occurrence of the depolarization peak of the RV is less than or equal to zero.

14. The method of claim 13,

wherein receiving a measure of a QRS complex duration into the external device includes:

communicating a request to the implantable device in response to the user prompt;

receiving a representation of a sensed RV cardiac signal and a representation of a sensed LV cardiac signal in response to the communicated request; and

measuring the QRS complex duration using at least one of the cardiac signals, and

wherein measuring the time of occurrence includes measuring a time of occurrence of a peak of depolarization of the RV using the representation of the RV cardiac signal measuring a time of occurrence of a peak of depolarization of the LV using the representation of the LV cardiac signal.

15. The method of claim 12, wherein measuring the time interval includes:

communicating a request to the implantable device in response to the user prompt;

receiving a representation of a cardiac signal sensed in the RV and a representation of a cardiac signal sensed in the LV in response to the communicated request;

measuring, with the external device, a duration interval between a cardiac event in the RV and a cardiac event in the LV using the received representations of the sensed cardiac signals; and

calculating, as a second generated therapy setting, an LV offset interval using the measured duration interval.

16. The method of claim 15, wherein calculating an LV offset interval includes:

calculating the LV offset interval using a first set of calculation coefficients when the measured time duration ends with an intrinsic cardiac event; and

calculating the LV offset interval using a second set of calculation coefficients when the measured time duration ends with a paced cardiac event.

17. The method of claim 15, including:

determining, with the external device, a frequency with which pacing therapy is delivered by the implantable device;

comparing, using the external device, the determined frequency of pacing to a specified pacing frequency value; and

adjusting, by the external device, calculation coefficients used to calculate the LV offset interval according to the comparison.

18. The method of claim 12, including:

communicating a request to the implantable device in response to the user prompt;

receiving, into the external device, a representation of a cardiac signal sensed in an atrium and a representation of a cardiac signal sensed in a ventricle in response to the communicated request;

measuring, with the external device, a time interval between a cardiac event in an atrium and a cardiac event in the ventricle using the received representations of the sensed cardiac signals; and

calculating, using the external device, an AV delay interval as a second generated therapy setting using the measured time interval.

19. The method of claim 18, wherein calculating the AV delay interval includes:

calculating the AV delay interval using a first set of calculation coefficients when the measured time interval ends with an intrinsic ventricular event; and

calculating the AV delay interval using a second set of calculation coefficients when the measured time interval ends with a paced ventricular event.

20. The method of claim 18,

determining, with the external device, a frequency with which intrinsic ventricular events are sensed by the implantable device;

comparing, using the external device, the frequency of intrinsic ventricular events to a specified sensed event frequency value; and

adjusting, by the external device, calculation coefficients used to calculate the AV delay interval according to the comparison.