IDENTIFICATION OF ABERRANT MEASUREMENTS OF IN VIVO GLUCOSE CONCENTRATION USING TEMPERATURE
First Claim
1. A method of identifying whether an intravascular glucose measurement is aberrant, the method comprising:
- deploying a sensor within a blood vessel, wherein the sensor comprises along a distal region thereof, a temperature-sensing element adapted to measure the temperature of the blood contacting the distal region, and a glucose-sensing chemical indicator system adapted to measure the glucose concentration in the blood contacting the distal region;
generating at a first time, a first temperature measurement (TO;
generating at a second time, a second temperature measurement (T2) and a glucose measurement;
comparing T1 and T2; and
identifying the glucose measurement as aberrant if the absolute magnitude of the difference between T1 and T2 exceeds a pre-selected threshold value.
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Abstract
Disclosed herein are methods and systems for generating an estimate of an in vivo analyte concentration and identifying whether the estimate is aberrant. In some embodiments, the system includes a sensor comprising an analyte sensor and a temperature sensing element, and a control unit programmed to identify changes in temperature that may indicate a non-physiologic condition (and result in an aberrant glucose measurement). In some embodiments, the methods include generating an estimate of analyte concentration at a particular time using the analyte sensor, and generating first and second signals indicative of temperature using the temperature sensing element. In some embodiments the methods include identifying the estimate of analyte concentration as aberrant if the magnitude of the difference between the first and second signals indicative of temperature exceeds a threshold value.
127 Citations
14 Claims
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1. A method of identifying whether an intravascular glucose measurement is aberrant, the method comprising:
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deploying a sensor within a blood vessel, wherein the sensor comprises along a distal region thereof, a temperature-sensing element adapted to measure the temperature of the blood contacting the distal region, and a glucose-sensing chemical indicator system adapted to measure the glucose concentration in the blood contacting the distal region; generating at a first time, a first temperature measurement (TO; generating at a second time, a second temperature measurement (T2) and a glucose measurement; comparing T1 and T2; and identifying the glucose measurement as aberrant if the absolute magnitude of the difference between T1 and T2 exceeds a pre-selected threshold value. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of identifying whether an intravascular glucose measurement is aberrant at a given time, the method comprising:
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deploying a sensor within a blood vessel, wherein the sensor comprises along a distal region thereof, a temperature-sensing element adapted to measure the temperature of the blood contacting the distal region, and a glucose-sensing chemical indicator system adapted to measure the glucose concentration in the blood contacting the distal region; generating one or more temperature measurements prior to the given time; generating simultaneously, at the given time, a temperature measurement and a glucose measurement; comparing the temperature measurement generated at the given time with an average of the temperature measurements generated prior to the given time; and identifying the glucose measurement generated at the given time as aberrant if the absolute magnitude of the difference between the temperature measurement generated at the given time and the average of the temperature measurements generated prior to the given time exceeds a pre-selected threshold value.
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8. A system for measuring an in vivo glucose concentration and identifying whether the measurement is aberrant, the system comprising:
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a glucose sensor comprising a chemical indicator system configured to generate a signal indicative of the in vivo concentration of the glucose at a first time; a temperature sensing element configured to generate a plurality of signals comprising; a first signal indicative of temperature at a second time prior to the first time; and a second signal indicative of temperature at the first time; at least one sensor control unit, the at least one sensor control unit configured to control the operation of the glucose sensor and the temperature sensing element; and at least one receiving and processing unit, the at least one receiving and processing unit configured to; receive the signal indicative of the in vivo concentration of the glucose; receive the first signal indicative of temperature; receive the second signal indicative of temperature; generate a metric from the first signal indicative of temperature and the second signal indicative of temperature, the metric indicative of the difference in temperature at the glucose sensor between the first time and second time; and identify the glucose concentration as aberrant if the metric exceeds a threshold value. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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Specification