FRICTIONAL TRANS-EPITHELIAL TISSUE DISRUPTION COLLECTION APPARATUS AND METHOD OF INDUCING AN IMMUNE RESPONSE
First Claim
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1. A device for obtaining a biopsy tissue sample comprising:
- (a) a handle including a proximal end and a distal end, wherein the handle has a first principal axis of rotation, wherein the principal axis of rotation bisects the proximal end of the handle and the distal end of the handle;
(b) a head with a proximal end and a distal end, wherein the proximal end of the head is attached to the distal end of the handle;
(c) at least a first facet associated with the head; and
(d) an abrasive material, wherein the abrasive material is attached to at least the first facet.
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Abstract
In an embodiment of the invention, a frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain tissue biopsy samples. A frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device is narrow and pointed with a hybrid pear shaped diamond facet. Abrasive material can be adhered to the facet.
128 Citations
20 Claims
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1. A device for obtaining a biopsy tissue sample comprising:
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(a) a handle including a proximal end and a distal end, wherein the handle has a first principal axis of rotation, wherein the principal axis of rotation bisects the proximal end of the handle and the distal end of the handle; (b) a head with a proximal end and a distal end, wherein the proximal end of the head is attached to the distal end of the handle; (c) at least a first facet associated with the head; and (d) an abrasive material, wherein the abrasive material is attached to at least the first facet. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of obtaining a biopsy sample in a fixing solution comprising:
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(a) selecting a Frictional Tissue Sampling and Collection (FTSC) head with an associated facet, wherein the FTSC head is received in a handle, wherein the handle has an axis of rotation, wherein one or more of the FTSC head size, FTSC head shape, facet size and facet shape are selected based on the nature of the biopsy sampling location to be sampled; (b) placing the head of the FTSC device on a biopsy sampling location; (c) rotating around the axis of rotation in a first direction one or both the handle and the FTSC head to frictionally abrade the biopsy sampling location; (d) removing the FTSC head from the biopsy sampling location; (e) using a comb to remove tissue obtained from the biopsy sampling location, wherein the tissue is removed by brushing the head in a second direction, wherein the second direction is opposite of the first direction; and (f) depositing the tissue removed from combing the head in step (e) in a fixing solution. - View Dependent Claims (16)
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17. A device for obtaining a biopsy tissue sample comprising:
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(a) a head including a proximal end and a distal end, wherein the head has a first maximum diameter; (b) a facet extending from the head, wherein the facet has a second maximum diameter, wherein the second maximum diameter is at least 1 mm less than the first maximum diameter; (b) a handle with a proximal and a distal end, wherein the proximal end of the head is connected to the distal end of the handle; and (c) an abrasive material, wherein the abrasive material is attached to the facet. - View Dependent Claims (18, 19, 20)
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Specification