APPARATUS AND METHODS FOR DELIVERY OF BRAIDED PROSTHESES

• US 20110178589A1
• Filed: 04/01/2011
• Published: 07/21/2011
• Est. Priority Date: 12/03/2001
• Status: Active Grant

• Current Assignee: JW Medical Systems Ltd
• Original Assignee: XTENT, Inc.
• Inventors: French, Ron, Andreas, Bernard, Gifford, Hanson S. III, Deem, Mark E., Will, Allan
• Granted Patent: US 8,574,282 B2
• Time in Patent Office: Days
• US Class Current: 623/1.11
• CPC Class Codes: A61B 1/00151 using everted tubes
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/9517 handle assemblies therefor
• CPC Class Codes: A61F 2/966 with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• CPC Class Codes: Y10S 623/903 Blood vessel

Abstract

Blood vessels and other body lumens are expanded using an evertible braided prosthesis. The braided prosthesis is delivered to the blood vessel in a radially collapsed configuration. A leading edge of the braided prosthesis is then everted so that it expands as it is advanced through the blood vessel. Optionally, the prosthesis can be provided with a biologically active substance in order to inhibit hyperplasia or have other desired biological effects.

Claims

1. An apparatus for delivering a prosthesis to a body lumen, said apparatus comprising:

a catheter comprising an outer tube having a passage;

a tubular prosthesis carried in the passage of the outer tube at least partially in a radially collapsed configuration; and

an inner tube slidably disposed within the passage of the outer tube, the inner tube having a lumen for receiving a guidewire and being capable of advancing the prosthesis from the passage as the inner tube is advanced distally relative to the outer tube, wherein the prosthesis everts and radially expands as it is advanced.

2. The apparatus of claim 1, further comprising a separation element for separating the prosthesis into a first portion which is released from the catheter while another portion remains carried at least partially in the passage.

3. The apparatus of claim 1, further comprising a middle tube slidably disposed within the passage of the outer tube and slidably disposed over the inner tube, wherein advancing the prosthesis comprises advancing the middle tube and inner tube distally relative to the outer tube.

4. The apparatus of claim 3, wherein at least a portion of the tubular prosthesis carried in the passageway of the outer tube is disposed between the inner tube and the middle tube.

5. The apparatus of claim 1, wherein a distal portion of the tubular prosthesis is everted over and coupled with an outer surface of the outer tube prior to advancing the prosthesis from the passage.

6. The apparatus of claim 1, wherein the tubular prosthesis is at least partially coated with a therapeutic agent.

7. The apparatus of claim 1, wherein the tubular prosthesis comprises a polymeric layer, wherein the polymeric layer is loaded with a therapeutic agent.

8. The apparatus of claim 1, further comprising an expandable member coupled with the outer tube for expanding the tubular prosthesis.

9. The apparatus of claim 1, wherein the tubular prosthesis comprises a braided prosthesis.

10. The apparatus of claim 1, wherein the tubular prosthesis comprises a metallic structure.

11. The apparatus of claim 1, further comprising a handle at a proximal end of the catheter, the handle being operable to advance the inner tube to evert the tubular prosthesis.

12. A method for delivering a prosthesis to a body lumen, said method comprising:

positioning a delivery catheter at a target site, the tubular catheter comprising;

an outer tube having a passage;

a tubular prosthesis carried in the passage of the outer tube at least partially in a radially collapsed configuration; and

an inner tube slidably disposed within the passage of the outer tube, the inner tube having a lumen for receiving a guidewire; and

advancing the inner tube distally relative to the outer tube to evert the tubular prosthesis so that an inside surface is exposed radially outwardly and advanced over a length of a wall of the body lumen.

13. The method of claim 12, further comprising radially expanding the tubular prosthesis with an expandable member of the delivery catheter so that the tubular prosthesis applies a radially outward force against inner wall.

14. The method of claim 12, further comprising severing the tubular prosthesis with a separation element so that a first portion of the tubular prosthesis is deployed at the target site while another portion of the tubular prosthesis remains carried in the passage.

15. The method of claim 12, further comprising operating a handle at a proximal end of the delivery catheter to advance the inner tube to evert the tubular prosthesis.

16. The method of claim 12, further comprising inflating a balloon so as to anchor the tubular prosthesis to the body lumen.

17. The method of claim 12, wherein the delivery catheter further comprises a middle tube slidably disposed within the passage of the outer tube and slidably disposed over the inner tube, and wherein the method further comprises advancing the middle tube with the inner tube to evert the tubular prosthesis.

18. The method of claim 12, further comprising releasing a therapeutic agent from the tubular prosthesis after deployment thereof.

19. The method of claim 18, wherein the therapeutic agent inhibits restenosis.

20. An apparatus for delivering a prosthesis to a body lumen, said apparatus comprising:

a catheter comprising a passage;

a tubular prosthesis carried in the passage at least partially in a radially collapsed configuration; and

a central tube slidably disposed within the passage, the central tube being capable of advancing the tubular prosthesis from the passage as the central tube is advanced distally, wherein the tubular prosthesis everts and radially expands as it is advanced, and wherein the tubular prosthesis is at least partially disposed within the central tube prior to advancement so that as the tubular prosthesis is advanced, the everted portion of the tubular prosthesis is disposed outside the central tube.