DEGRADATION RESISTANT IMPLANTABLE MATERIALS AND METHODS

• US 20110196488A1
• Filed: 01/27/2011
• Published: 08/11/2011
• Est. Priority Date: 02/03/2010
• Status: Abandoned Application

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Ma, Kevin A., Abiad, Miriam M., Goraltchouk, Alexei, Thompson, Jordan M.
• Application Number:
  US13/015,309
• Publication Number:
  US 20110196488A1
• Time in Patent Office: Days
• US Class Current: 623/8
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 27/12 containing fluorine atoms
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/249999 Differentially filled foam, filled plural layers, or filled layer with coat of filling material

Abstract

Methods are provided for making materials suitable for implantation in a mammal. The methods include the steps of providing a base material having a desirable surface topography, such as a polyurethane foam, contacting the base member with a silicone-based fluid material to form a coating, and allowing the coating to set to form a silicone-based structure suitable for implantation in a mammal. The base material may be removed from the coating.

Claims

1. A method of making a material suitable for implantation in a mammal, the method comprising:

providing a base member including a porous surface defined by interconnected pores;

contacting the base member with a silicone-based fluid material in a manner to cause the fluid material to enter the pores;

removing excess fluid material from the base member to obtain a coating of the fluid material on the porous surface; and

allowing the coating to set to form a silicone-based structure suitable for implantation in a mammal, the silicone-based structure including a porous surface substantially identically conforming to the porous surface of the base member.

2. The method of claim 1 further comprising the step of applying a vacuum to the base member to draw the fluid material into the pores.

3. The method of claim 1 further comprising removing at least a portion of the base member from the silicone-based structure.

4. The method of claim 1 wherein the base member is substantially polyurethane.

5. The method of claim 1 wherein the base member is substantially melamine.

6. The method of claim 1 wherein the coating has a thickness of between about 10 microns and about 100 microns.

7. The method of claim 1 further comprising the step of removing substantially all of the base member from the coating after the step of allowing the coating to set.

8. The method of claim 7 wherein the step of removing comprises contacting the base member with a solution capable of dissolving the base member.

21. A method for augmenting or reconstructing a human breast comprising the steps of:

implanting the material made by the method of claim 1 in a human breast.

9. A method of making a material suitable for implantation in a mammal, the method comprising:

providing a base member comprising a biodegradable foam and including a porous surface defined by interconnected pores;

contacting the base member with a fluid precursor of a substantially non-biodegradable polymeric material in a manner to cause the fluid precursor to enter the pores;

removing excess fluid precursor from the base member to obtain a coating of the fluid precursor on the porous surface; and

allowing the coating to set to form a substantially non-biodegradable polymeric structure suitable for implantation in a mammal, the substantially non-biodegradable polymeric structure including a porous surface substantially identically conforming to the porous surface of the base member.

10. The method of claim 9 wherein the biodegradable foam is a polyurethane foam.

11. The method of claim 9 further comprising the step of removing at least a portion of the base member from the substantially non-biodegradable polymeric structure.

12. The method of claim 9 wherein the substantially non-biodegradable polymeric structure is substantially entirely silicone.

13. A method of making a material suitable for implantation in a mammal, the method comprising:

providing a base member made of a biodegradable foam and including a porous surface defined by interconnected pores;

contacting the base member with a fluorinated polyolefin material in a manner to cause the fluorinated polyolefin material to enter the pores;

allowing the fluorinated polyolefin material to set to form a fluorinated polyolefin coating on the base member;

contacting the fluorinated polyolefin coating with a silicone-based fluid material;

allowing the silicone-based fluid material to set to form a layered polymeric structure suitable for implantation in a mammal, the layered polymeric structure including a porous surface substantially identically conforming to the porous surface of the base member.

14. A method of making a material suitable for implantation in a mammal, the method comprising:

providing a polymeric base member having a surface defined by a geometry including interconnected pores;

forming a first coating on the surface of the base member material, the first coating being selected from the group of materials consisting of polystyrene, polyethylene-co-vinyl acetate, and poly(styrene-co-butadiene-co-styrene);

removing the polymeric base member by contacting the base material with a material that will cause the base member to be removed from the first coating without causing degradation of the coating;

applying a silicone-based fluid material to the first coating having the polymeric base member removed therefrom;

curing the silicone-based fluid material to form a silicone-based coating on the first coating; and

removing the first coating from the silicone coating.

15. The method of claim 14 wherein the step of removing the first coating comprises contacting the first coating with a material that dissolves the first coating without substantially affecting the silicone coating.

16. A method of making a material suitable for implantation in a mammal, the method comprising:

providing a base material comprising polyurethane foam having a surface defined by interconnected pores;

contacting the base material with a fluorinated polymeric material in a manner to cause the fluorinated polymeric material to enter the pores and form a fluorinated polymeric coating on the base material thereby forming a biocompatible, substantially non-biodegradable composite material.

17. The method of claim 16 wherein the fluorinated polymeric material is a fluorinated polyolefin.

18. The method of claim 16 further comprising the step of applying a silicone-based material to the fluorinated polymeric coating in a manner to form a conformal silicone-based coating on the fluorinated polymeric coating.

19. The method of claim 16 further comprising the step of applying vacuum to the base material during the step of contacting.

20. A composite material made by the method of claim 16.