ADMINISTRATION DEVICE HAVING A BOLUS ADMINISTRATION PROFILE CONTROLLER

• US 20110202040A1
• Filed: 08/18/2010
• Published: 08/18/2011
• Est. Priority Date: 02/21/2008
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Inventors: Kalt, Lucas, Remde, Axel
• Granted Patent: US 8,715,268 B2
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

According to one embodiment, an administration device for subcutaneous administration of a liquid drug over an extended period of time is provided. The administration device may include an administration unit, a housing, and a controller unit. The administration unit may include a drug reservoir and a pump unit. The housing may include the administration unit and may be adapted to be carried by a patient over an extend period of time. The controller unit may include a bolus administration profile controller. The bolus administration profile controller receives a bolus volume of a bolus to be administered and determines based, at least in part, on the bolus volume a bolus administration profile such that a depot volume of a depot is limited.

Claims

1. An administration device for subcutaneous administration of a liquid drug to tissue of a patient over an extended period of time, the administration device comprising:

an administration unit, the administration unit comprising a drug reservoir and a pump unit;

a housing, the housing comprising the administration unit and being adapted to be carried by a patient over an extend period of time; and

a controller unit, the controller unit comprising a bolus administration profile controller, wherein;

the bolus administration profile controller receives a bolus volume of a bolus to be administered; and

determines based, at least in part, on the received bolus volume a bolus administration profile such that a depot volume of a depot is limited, wherein the depot is a subcutaneous drug depot that is present during and shortly after the administration until the drug is absorbed by the tissue.

2. The administration device of claim 1 further comprising a user interface, wherein the user interface is coupled to the controller unit and receives a bolus administration command.

3. The administration device of claim 2 wherein the user interface indicates a reception of the bolus administration command with the administration device being concealed from view.

4. The administration device of claim 1 wherein the bolus administration profile controller is adapted to be selectively deactivated.

5. The administration device of claim 4 wherein a user interface receives a bolus administration command in at least two different ways and the bolus administration profile controller is selectively deactivated in dependence upon the at least two different ways the bolus administration command is received by the user interface.

6. The administration device of claim 1 wherein the depot volume of the depot does not exceed a depot volume threshold.

7. The administration device of claim 6 wherein the depot volume threshold is defined by a maximum depot volume such that the maximum depot volume is a maximum volume that may be stored in the depot.

8. The administration device of claim 1 wherein the bolus administration profile comprises an immediate bolus administration profile corresponding to an immediate bolus having an immediate bolus volume.

9. The administration device of claim 8 wherein the immediate bolus volume does not exceed a bolus volume threshold.

10. The administration device of claim 1 wherein the bolus administration profile comprises an extended bolus administration profile corresponding to an extended bolus having an extended bolus volume.

11. The administration device of claim 10 wherein the extended bolus is a series of extended bolus pulses.

12. The administration device of claim 11 wherein a bolus pulse volume of the extended bolus pulses does not exceed a bolus pulse volume threshold.

13. The administration device of claim 11 wherein the administration device performs a basal administration according to a basal profile.

14. The administration device of claim 13 wherein:

the controller unit controls the administration unit;

the administration unit administers combined pulses; and

each of the combined pulses comprises an extended bolus pulse and a basal pulse.

15. The administration device of claim 14 wherein a combined pulse volume of the combined pulses does not exceed a pulse volume threshold.

16. The administration device of claim 1 wherein:

the bolus administration profile comprises at least two bolus sub volumes;

the at least two bolus sub volumes sum up to the bolus volume B; and

the bolus administration profile controller determines the at least two bolus sub volumes.

17. The administration device of claim 1 wherein:

the administration device administers drug pulses;

the bolus administration profile controller determines a pulse volume and/or a pulse interval such that the depot volume of the depot does not exceed a depot volume threshold.

18. The administration device of claim 1 wherein the administration device administers a first bolus having a first bolus volume and a second bolus having a second bolus volume wherein the bolus administration profile controller determines a first administration profile and a further administration profile based at least in part on the first bolus administration profile and/or on an administration state of the first bolus when an administration of the second bolus is commanded while the second bolus is being administered.

19. A method for controlling a pump unit of an administration device, the administration device being adapted for subcutaneous administration of a liquid drug to tissue of a patient over an extended period of time, the method comprising:

providing a bolus volume of a bolus to be administered;

determining, with a bolus administration profile controller, a bolus administration profile of the bolus to be administered, at least in part, based on the provided bolus volume, wherein a depot volume of a depot is limited, and wherein the depot is a subcutaneous drug depot that is present during and shortly after the administration until the drug is absorbed by the tissue; and

controlling the pump unit to administer the bolus according to the bolus administration profile determined by the bolus administration profile controller.

20. The method of claim 19 further comprising providing a drug reservoir comprising insulin.

21. The method of claim 20 further comprising determining the bolus administration profile based at least in part on pharmacokinetics of the insulin and/or on food absorption characteristics.

22. The method of claim 20 further comprising determining the bolus volume based at least in part on a blood glucose value of a diabetic person.