METHODS FOR MODIFYING VASCULAR VESSEL WALLS

• US 20110224484A1
• Filed: 03/15/2011
• Published: 09/15/2011
• Est. Priority Date: 11/03/2004
• Status: Active Grant

• Current Assignee: Cook Biotech Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Inventors: Case, Brian C., Patel, Umesh H., Flagle, Jacob A., Obermiller, F. Joseph, Hiles, Michael C.
• Granted Patent: US 8,834,351 B2
• Time in Patent Office: Days
• US Class Current: 600/37
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/3645 Connective tissue
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/3839 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60

Abstract

This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

Claims

1. A method of treating a patient to modify a vascular vessel having a defect, the method comprising:

accessing a treatment site proximate to a defect in a vascular vessel, wherein said treatment site is associated with a vascular valve; and

introducing a flowable biomaterial into a vessel wall at the treatment site.

3. The method of claim 1 wherein said accessing comprises inserting a cannulated delivery device intra-lumenally through the vascular vessel.

4. The method of claim 1 wherein said biomaterial is angiogenic.

5. The method of claim 3 wherein said introducing comprises injecting the biomaterial through the cannulated delivery device into the vessel wall.

7. The method of claim 1 wherein said accessing comprises inserting a cannulated delivery device exo-lumenally to the treatment site.

8. The method of claim 7 comprising injecting the biomaterial through the cannulated delivery device into the vessel wall.

10. The method of claim 1 comprising injecting the biomaterial into two or more sites spaced circumferentially about the vascular vessel.

15. The method of claim 1 wherein said introducing comprises delivering the biomaterial into the wall or external of the vascular vessel to reshape the vascular vessel.

17. The method of claim 1 wherein the biomaterial comprises an extracellular matrix material.

18. The method of claim 1 wherein the biomaterial comprises submucosa tissue.

19. The method of claim 1 wherein the biomaterial comprises collagen.

20. The method of claim 18, wherein said submucosa is porcine, bovine, or ovine submucosa.

21. The method of claim 1 wherein the biomaterial comprises a bioactive substance.

22. The method of claim 1 wherein the biomaterial comprises a population of viable cells.

23. The method of claim 22 wherein the cells comprise autologous cells.

53. The method of claim 1, wherein the biomaterial is remodelable.

2. (canceled)

6. (canceled)

9. (canceled)

11-14. -14. (canceled)

16. (canceled)

24-52. -52. (canceled)