DIABETES THERAPY DEVICE ENABLING SHIFTING OF PARAMETER PROFILES

• US 20110238033A1
• Filed: 09/23/2010
• Published: 09/29/2011
• Est. Priority Date: 09/25/2009
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Inventors: Hellwig, Robert, Teupe, Bernhard, Prud'homme, Thierry, Prod'hom, Gilles
• Granted Patent: US 9,242,038 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

A diabetes therapy device is disclosed herein, which includes a profile memory storing a parameter profile and a dedicated reference time mark. The parameter profile defines at least one parameter that is associated with insulin administration as a function of time for a generally circadian chronobiological cycle. The reference time mark indicates the beginning of the circadian chronobiological cycle and initializes a running time. Insulin amounts to be administered are determined as a function of the running time in accordance with a current matching of the parameter profile. A modified matching based on the reference time mark and an upcoming trigger time is computed and is time-shifted from the current matching, wherein the modified matching is applied by making the modified matching the current matching, such that future insulin amounts to be administered are determined in accordance with the modified matching.

Claims

1. A diabetes therapy device comprising:

a profile memory, wherein the profile memory stores a parameter profile and a reference time mark,

wherein the parameter profile defines at least one parameter that is associated with insulin administration as a function of time for a generally circadian chronobiological cycle,

wherein the reference time mark indicates the beginning of the generally circadian chronobiological cycle and initializes a running time; and

a controller unit,

wherein the controller unit is coupled to the profile memory and determines insulin amounts to be administered as a function of the running time in accordance with a current matching of the parameter profile and the running time,

wherein the determined insulin amounts are based on the at least one parameter,

wherein the controller unit modifies the current matching of the parameter profile and the running time, and

wherein the controller unit;

receives trigger information that is indicative of an upcoming cycle trigger event occurring at an upcoming trigger time, wherein the upcoming cycle trigger event is a defined event that generally occurs once per day and triggers the beginning of the generally circadian chronobiological cycle,

computes a modified matching based on the reference time mark and the upcoming trigger time, wherein the modified matching is time-shifted from the current matching, and

applies the modified matching by making the modified matching the current matching, such that future insulin amounts to be administered are determined in accordance with the modified matching.

2. The diabetes therapy device of claim 1, wherein the at least one parameter comprises at least one of a carbohydrate factor and a blood glucose correction factor.

3. The diabetes therapy device of claim 1, further comprising a pump unit, wherein the at least one parameter comprises a basal infusion rate, and wherein the parameter profile comprises a basal rate profile, and wherein the controller unit controls a quasi-continuous insulin infusion by the pump unit as a function of the running time in accordance with the basal rate profile and the current matching.

4. The diabetes therapy device of claim 1, wherein the at least one parameter comprises a set of parameters, and wherein the profile memory stores a common reference time mark for the set of parameters.

5. The diabetes therapy device of claim 1, wherein the upcoming cycle trigger event is associated with the diabetic going to bed, falling asleep or waking up.

6. The diabetes therapy device according to claim 5, further comprising a going-to-bed sensor, wherein the going-to-bed sensor is operatively coupled to the controller unit, and wherein the going-to-bed sensor detects at least one of the following actions:

falling asleep, being asleep, waking up, getting up, and an auxiliary event, wherein the occurrence of the auxiliary event is correlated with falling asleep, being asleep, waking up, or getting up.

7. The diabetes therapy device of claim 1, wherein the controller unit computes the modified matching such that the reference time mark is aligned with the upcoming trigger time.

8. The diabetes therapy device of claim 1, wherein the profile memory stores a standard matching of the parameter profile, and wherein the controller unit applies the standard matching by making the standard matching the current matching, such that the future insulin amounts to be determined with the standard matching.

9. The diabetes therapy device of claim 1, wherein the controller unit temporarily determines the insulin amounts to be administered in accordance with a transition profile, wherein the insulin amount determination according to the transition profile bridges the insulin amount determination according to the current matching and the insulin amount determination according to the modified matching.

10. The diabetes therapy device of claim 9, wherein the transition profile has a time span shorter than the length of the generally circadian chronobiological cycle.

11. The diabetes therapy device of claim 9, wherein the transition profile is either constant or is given by a section of the parameter profile stored by the profile memory.

12. The diabetes therapy device of claim 1, wherein controller unit temporarily blocks the application of the modified matching.

13. The diabetes therapy device according to claim 12, wherein the controller unit temporarily blocks applying the modified matching if a time difference of the upcoming trigger time to a last previous occurrence of the cycle trigger time is smaller than a minimum cycle interval.

14. The diabetes therapy device of claim 1, wherein the controller unit applies the modified matching without having received information indicative of a cycle trigger event.

15. The diabetes therapy device according to claim 14, wherein the controller unit receives information indicative of a further event, and wherein the controller unit applies the modified matching if the difference between a current point in time and a previous occurrence time of the further event exceeds a maximum awake interval without a cycle trigger event having occurred since the previous occurrence time of the further event.

16. A diabetes therapy device comprising:

a profile memory, wherein the profile memory stores a parameter profile and a reference time mark,

wherein the parameter profile defines at least one parameter that is associated with insulin administration as a function of time for a generally circadian chronobiological cycle,

wherein the reference time mark indicates the beginning of the generally circadian chronobiological cycle and initializes a running time; and

a controller unit and a going-to-bed sensor,

wherein the controller unit is coupled to the profile memory and determines insulin amounts to be administered as a function of the running time in accordance with a current matching of the parameter profile and the running time,

wherein the determined insulin amounts are based on the at least one parameter,

wherein the controller unit modifies the current matching of the parameter profile and the running time, and

wherein the controller unit;

receives trigger information that is indicative of an upcoming cycle trigger event occurring at an upcoming trigger time,

wherein the upcoming cycle trigger event is a defined event that generally occurs once per day and triggers the beginning of the generally circadian chronobiological cycle, wherein the upcoming cycle trigger event is associated with the diabetic going to bed, falling asleep or waking up, and

wherein the going-to-bed sensor is operatively coupled to the controller unit, and wherein the going-to-bed sensor detects at least one of the following actions;

falling asleep, being asleep, waking up, getting up, and an auxiliary event, wherein the occurrence of the auxiliary event is correlated with falling asleep, being asleep, waking up, or getting up,

computes a modified matching based on the reference time mark and the upcoming trigger time, wherein the modified matching is time-shifted from the current matching, and

applies the modified matching by making the modified matching the current matching, such that future insulin amounts to be administered are determined in accordance with the modified matching.

17. A method of treating diabetes, the method comprising:

providing a profile memory, wherein the profile memory stores a parameter profile and a reference time mark,

wherein the parameter profile defines at least one parameter that is associated with insulin administration as a function of time for a generally circadian chronobiological cycle,

wherein the reference time mark indicates the beginning of the generally circadian chronobiological cycle and initializes a running time;

providing a controller unit,

wherein the controller unit is coupled to the profile memory and determines insulin amounts to be administered as a function of the running time in accordance with a current matching of the parameter profile and the running time,

wherein the determined insulin amounts are based on the at least one parameter, and

wherein the controller unit modifies the current matching of the parameter profile and the running time;

receiving trigger information that is indicative of an upcoming cycle trigger event occurring at an upcoming trigger time, wherein the upcoming cycle trigger event is a defined event that generally occurs once per day and triggers the beginning of the generally circadian chronobiological cycle;

computing a modified matching based on the reference time mark and the upcoming trigger time, wherein the modified matching is time-shifted from the current matching; and

applying the modified matching by making the modified matching the current matching, such that future insulin amounts to be administered are determined in accordance with the modified matching.

18. The method of claim 17, wherein the at least one parameter comprises at least one of a carbohydrate factor and a blood glucose correction factor.

19. The method of claim 17, wherein the at least one parameter comprises a basal infusion rate, and wherein the parameter profile comprises a basal rate profile.

20. The method of claim 17, further comprising determining temporarily the insulin amounts to be administered in accordance with a transition profile, wherein the insulin amount determination according to the transition profile bridges the insulin amount determination according to the current matching and the insulin amount determination according to the modified matching.